Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308128843> ?p ?o ?g. }
- W4308128843 endingPage "5363" @default.
- W4308128843 startingPage "5363" @default.
- W4308128843 abstract "Squamous cell carcinoma is the most common malignancy that arises in the head-and-neck district. Traditional treatment could be insufficient in case of recurrent and/or metastatic cancers; for this reason, more selective and enhanced treatments are in evaluation in preclinical and clinical trials to increase in situ concentration of chemotherapy drugs promoting a selectively antineoplastic activity. Among all cancer treatment types (i.e., surgery, chemotherapy, radiotherapy), electroporation (EP) has emerged as a safe, less invasive, and effective approach for cancer treatment. Reversible EP, using an intensive electric stimulus (i.e., 1000 V/cm) applied for a short time (i.e., 100 μs), determines a localized electric field that temporarily permealizes the tumor cell membranes while maintaining high cell viability, promoting cytoplasm cell uptake of antineoplastic agents such as bleomycin and cisplatin (electrochemotherapy), calcium (Ca2+ electroporation), siRNA and plasmid DNA (gene electroporation). The higher intracellular concentration of antineoplastic agents enhances the antineoplastic activity and promotes controlled tumor cell death (apoptosis). As secondary effects, localized EP (i) reduces the capillary blood flow in tumor tissue (“vascular lock”), lowering drug washout, and (ii) stimulates the immune system acting against cancer cells. After years of preclinical development, electrochemotherapy (ECT), in combination with bleomycin or cisplatin, is currently one of the most effective treatments used for cutaneous metastases and primary skin and mucosal cancers that are not amenable to surgery. To reach this clinical evidence, in vitro and in vivo models were preclinically developed for evaluating the efficacy and safety of ECT on different tumor cell lines and animal models to optimize dose and administration routes of drugs, duration, and intensity of the electric field. Improvements in reversible EP efficacy are under evaluation for HNSCC treatment, where the focus is on the development of a combination treatment between EP-enhanced nanotechnology and immunotherapy strategies." @default.
- W4308128843 created "2022-11-08" @default.
- W4308128843 creator A5002453648 @default.
- W4308128843 creator A5014239599 @default.
- W4308128843 creator A5030283020 @default.
- W4308128843 creator A5036491149 @default.
- W4308128843 creator A5036706048 @default.
- W4308128843 creator A5050504480 @default.
- W4308128843 creator A5064069613 @default.
- W4308128843 creator A5068946724 @default.
- W4308128843 creator A5076711012 @default.
- W4308128843 date "2022-10-31" @default.
- W4308128843 modified "2023-10-15" @default.
- W4308128843 title "Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination" @default.
- W4308128843 cites W1485297825 @default.
- W4308128843 cites W1518120013 @default.
- W4308128843 cites W1571418278 @default.
- W4308128843 cites W1583746243 @default.
- W4308128843 cites W1597938223 @default.
- W4308128843 cites W1749625474 @default.
- W4308128843 cites W1835443511 @default.
- W4308128843 cites W1860534622 @default.
- W4308128843 cites W1904722209 @default.
- W4308128843 cites W1910633347 @default.
- W4308128843 cites W1969959009 @default.
- W4308128843 cites W1978068596 @default.
- W4308128843 cites W1979908488 @default.
- W4308128843 cites W1982580620 @default.
- W4308128843 cites W1984712676 @default.
- W4308128843 cites W1985335182 @default.
- W4308128843 cites W1989230986 @default.
- W4308128843 cites W1994469753 @default.
- W4308128843 cites W1994505979 @default.
- W4308128843 cites W1995455267 @default.
- W4308128843 cites W2008522415 @default.
- W4308128843 cites W2012939150 @default.
- W4308128843 cites W2014669469 @default.
- W4308128843 cites W2021312203 @default.
- W4308128843 cites W2022953507 @default.
- W4308128843 cites W2024504263 @default.
- W4308128843 cites W2030908446 @default.
- W4308128843 cites W2036145275 @default.
- W4308128843 cites W2039621244 @default.
- W4308128843 cites W2043239560 @default.
- W4308128843 cites W2044469114 @default.
- W4308128843 cites W2045152418 @default.
- W4308128843 cites W2048634485 @default.
- W4308128843 cites W2050096328 @default.
- W4308128843 cites W2050365830 @default.
- W4308128843 cites W2050660237 @default.
- W4308128843 cites W2051925512 @default.
- W4308128843 cites W2052649413 @default.
- W4308128843 cites W2055275963 @default.
- W4308128843 cites W2056036966 @default.
- W4308128843 cites W2062007302 @default.
- W4308128843 cites W2065288857 @default.
- W4308128843 cites W2068332684 @default.
- W4308128843 cites W2076819072 @default.
- W4308128843 cites W2078800133 @default.
- W4308128843 cites W2083424152 @default.
- W4308128843 cites W2089598452 @default.
- W4308128843 cites W2090105295 @default.
- W4308128843 cites W2090900427 @default.
- W4308128843 cites W2091246492 @default.
- W4308128843 cites W2093001890 @default.
- W4308128843 cites W2108116674 @default.
- W4308128843 cites W2119456602 @default.
- W4308128843 cites W2122387392 @default.
- W4308128843 cites W2129019273 @default.
- W4308128843 cites W2133624660 @default.
- W4308128843 cites W2138651796 @default.
- W4308128843 cites W2140013534 @default.
- W4308128843 cites W2140031668 @default.
- W4308128843 cites W2141405401 @default.
- W4308128843 cites W2162071711 @default.
- W4308128843 cites W2164217686 @default.
- W4308128843 cites W2164658411 @default.
- W4308128843 cites W2166621815 @default.
- W4308128843 cites W2167061508 @default.
- W4308128843 cites W2168725163 @default.
- W4308128843 cites W2170594982 @default.
- W4308128843 cites W2225000132 @default.
- W4308128843 cites W2243888955 @default.
- W4308128843 cites W2285547302 @default.
- W4308128843 cites W2312253207 @default.
- W4308128843 cites W2340110554 @default.
- W4308128843 cites W2409987634 @default.
- W4308128843 cites W2410642256 @default.
- W4308128843 cites W2412507794 @default.
- W4308128843 cites W2417722289 @default.
- W4308128843 cites W2464310977 @default.
- W4308128843 cites W2516305688 @default.
- W4308128843 cites W2529574284 @default.
- W4308128843 cites W2585754738 @default.
- W4308128843 cites W2588644110 @default.
- W4308128843 cites W2588651221 @default.
- W4308128843 cites W2598414716 @default.
- W4308128843 cites W2599276599 @default.