FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308133054> ?p ?o ?g. }

• W4308133054 endingPage "A133" @default.
• W4308133054 startingPage "A133" @default.
• W4308133054 abstract "Abstract Introduction Frailty is characterized by multisystem function decline related to aging and can be measured using frailty Index (FI). FI is constructed based on the proportion of deficits present in an individual out of the total number of health variables considered. FI in various populations has been shown to predict adverse health outcomes. We aimed to determine the impact of hormone excess on frailty in a prospective cohort of patients with adrenal adenomas. Methods We conducted a multicenter prospective observational study of adult patients with adrenal adenomas and referent subjects without adrenal disorders (Jan 2019-Dec 2021). Adrenal adenomas comprised non-functioning adrenal adenomas (NFA), adenomas with mild autonomous cortisol secretion (MACS), defined as dexamethasone suppression test (DST)&gt;1.8 mcg/dL, Cushing syndrome (CS), and primary aldosteronism (PA). FI was calculated as a sum of 47 variables (20 comorbidities, 13 symptoms, 14 activities of daily living) divided by 47.1 Frailty was defined as FI&gt;0.25. In a subset of patients (n=176), functional measurements (handgrip strength, timed up and go test, gait speed) were performed and compared to FI. Results Of 233 patients (72.1% women), 71 were diagnosed with NFA (median age 64.5 years), 108 with MACS (median age 60.7 years), 11 with CS (median age 58.0 years), 46 with PA (median age 52.4 years), and 33 were referent subjects (median age 51.3 years). When compared to referent subjects, age- and sex-adjusted frailty prevalence was highest in CS (OR 29, 95%CI 4.3-202), followed by MACS (OR 16, 95%CI 3.5-73.7), and PA (OR 11.7, 95%CI 2.4-56), but not in patients with NFA (OR 5.1, 95%CI 0.99-25.8). Compared to patients with NFA, age- and sex-adjusted frailty prevalence was higher in CS (OR 5.8, 95%CI 1.4-24.4) and in MACS (OR 3.2, 95%CI 1.5-6.7), but not in PA (OR 2.3, 95%CI 0.9-6.1) group. Subgroup-analysis based on DST demonstrated a similar increase in age- and sex-adjusted frailty prevalence in patients with DST&gt;5 mcg/dL (OR 3.1, 95%CI 1.2-8.2) and DST 1.9-5 mcg/dL (OR 3.3, 95%CI 1.5-7.4) when compared to patients with DST&lt;1.8 mcg/dL. Higher FI was associated with lower handgrip measurement (P&lt;0.0001), longer time during timed up and go test (P &lt;0.0001), and decreased gait speed (P&lt;0.0001). Conclusions Patients with functional adrenal adenomas are more likely to be frail. In patients with MACS, the prevalence of frailty was not associated with the degree of DST abnormality. FI correlated with currently validated but more cumbersome functional measurements and is a valuable tool that could be easily used in clinical practice and help individualize management decisions in patients with adrenal adenomas. 1 Singh S et al. Frailty in Patients With Mild Autonomous Cortisol Secretion is Higher Than in Patients with Nonfunctioning Adrenal Tumors. JCEM 2020 Presentation: Saturday, June 11, 2022 1:30 p.m. - 1:35 p.m., Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m." @default.
• W4308133054 created "2022-11-08" @default.
• W4308133054 creator A5014336548 @default.
• W4308133054 creator A5034012396 @default.
• W4308133054 creator A5052074609 @default.
• W4308133054 creator A5054687806 @default.
• W4308133054 creator A5074738537 @default.
• W4308133054 creator A5075527176 @default.
• W4308133054 creator A5082205854 @default.
• W4308133054 creator A5084783349 @default.
• W4308133054 creator A5086009289 @default.
• W4308133054 creator A5089399057 @default.
• W4308133054 date "2022-11-01" @default.
• W4308133054 modified "2023-09-23" @default.
• W4308133054 title "RF09 | PSUN05 Increased Frailty in Patients With Functioning Adrenal Adenomas" @default.
• W4308133054 doi "https://doi.org/10.1210/jendso/bvac150.271" @default.
• W4308133054 hasPublicationYear "2022" @default.
• W4308133054 type Work @default.
• W4308133054 citedByCount "0" @default.
• W4308133054 crossrefType "journal-article" @default.
• W4308133054 hasAuthorship W4308133054A5014336548 @default.
• W4308133054 hasAuthorship W4308133054A5034012396 @default.
• W4308133054 hasAuthorship W4308133054A5052074609 @default.
• W4308133054 hasAuthorship W4308133054A5054687806 @default.
• W4308133054 hasAuthorship W4308133054A5074738537 @default.
• W4308133054 hasAuthorship W4308133054A5075527176 @default.
• W4308133054 hasAuthorship W4308133054A5082205854 @default.
• W4308133054 hasAuthorship W4308133054A5084783349 @default.
• W4308133054 hasAuthorship W4308133054A5086009289 @default.
• W4308133054 hasAuthorship W4308133054A5089399057 @default.
• W4308133054 hasBestOaLocation W43081330541 @default.
• W4308133054 hasConcept C126322002 @default.
• W4308133054 hasConcept C187212893 @default.
• W4308133054 hasConcept C188816634 @default.
• W4308133054 hasConcept C2777428134 @default.
• W4308133054 hasConcept C2778914232 @default.
• W4308133054 hasConcept C2780233176 @default.
• W4308133054 hasConcept C2780401358 @default.
• W4308133054 hasConcept C2780455818 @default.
• W4308133054 hasConcept C71924100 @default.
• W4308133054 hasConcept C72563966 @default.
• W4308133054 hasConcept C84393581 @default.
• W4308133054 hasConceptScore W4308133054C126322002 @default.
• W4308133054 hasConceptScore W4308133054C187212893 @default.
• W4308133054 hasConceptScore W4308133054C188816634 @default.
• W4308133054 hasConceptScore W4308133054C2777428134 @default.
• W4308133054 hasConceptScore W4308133054C2778914232 @default.
• W4308133054 hasConceptScore W4308133054C2780233176 @default.
• W4308133054 hasConceptScore W4308133054C2780401358 @default.
• W4308133054 hasConceptScore W4308133054C2780455818 @default.
• W4308133054 hasConceptScore W4308133054C71924100 @default.
• W4308133054 hasConceptScore W4308133054C72563966 @default.
• W4308133054 hasConceptScore W4308133054C84393581 @default.
• W4308133054 hasIssue "Supplement_1" @default.
• W4308133054 hasLocation W43081330541 @default.
• W4308133054 hasLocation W43081330542 @default.
• W4308133054 hasOpenAccess W4308133054 @default.
• W4308133054 hasPrimaryLocation W43081330541 @default.
• W4308133054 hasRelatedWork W1965297339 @default.
• W4308133054 hasRelatedWork W1987160951 @default.
• W4308133054 hasRelatedWork W2078188957 @default.
• W4308133054 hasRelatedWork W2386379431 @default.
• W4308133054 hasRelatedWork W2921226052 @default.
• W4308133054 hasRelatedWork W2951601472 @default.
• W4308133054 hasRelatedWork W3023925359 @default.
• W4308133054 hasRelatedWork W3138008493 @default.
• W4308133054 hasRelatedWork W4200170393 @default.
• W4308133054 hasRelatedWork W2522747606 @default.
• W4308133054 hasVolume "6" @default.
• W4308133054 isParatext "false" @default.
• W4308133054 isRetracted "false" @default.
• W4308133054 workType "article" @default.