Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308133457> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4308133457 endingPage "A499" @default.
- W4308133457 startingPage "A499" @default.
- W4308133457 abstract "Abstract Background Cabergoline-resistant prolactinomas comprise approximately 10% of all prolactinomas, and sometimes show aggressive features including invasion or higher proliferation profiles. The treatment for such cabergoline-resistant aggressive prolactinomas is challenging and requires a multidisciplinary approach. Clinical case: A 47-year-old woman was diagnosed with hyperprolactinemia after complaining of menstrual irregularities at 20 years old. No neoplastic lesion was identified in the suprasellar region, and 0.25 mg/week cabergoline was initiated. At 35 years’ old, an adenoma was suspected on the right side of the pituitary gland, though plasma prolactin values were sustained without any clinical symptoms. When the patient was 46 years old, her prolactin levels elevated to 202 ng/ml, and magnetic resonance imaging showed a tumor invaded bilateral cavernous sinuses. Because prolactin levels and tumor size continued to increase despite increasing the cabergoline dose to 1 mg/week, endoscopic transsphenoidal surgery was performed. The tumor nearly total removal, the postoperative prolactin levels decreased to 00, but started to increase again in a short period of time. Pathologic assessment revealed a high Ki-67 index (20%) and diffusely positive prolactin alongside negative expression of other anterior hormones. The tumor remained in the cavernous sinus and postoperative prolactin levels tended to increase over time. Cabergoline was restarted and increased to 7mg/week, although prolactin levels were not suppressed. Magnetic resonance imaging and computed tomography scanning showed no metastasis, and octreotide scintigraphy revealed no abnormal accumulation except for the tumor in the cavernous sinus. Radiation therapy was administered to the remaining tumor, and prolactin levels gradually decreased. Thereafter, hypercalcemia and high intact parathyroid hormone levels were found in the presence of left-inferior parathyroid enlargement, leading to a diagnosis of multiple endocrine neoplasia type 1 (MEN1). The patient had no family history of endocrine disease. MEN1 gene mutation was not detected by direct sequencing. Discussion Functional pituitary adenomas including prolactinomas and growth hormone-producing pituitary adenomas are usually benign with a Ki-67 index of approximately 1%, little mitosis, and slow progression 1) . However, pituitary adenomas in MEN1 patients have a higher rate of drug resistance and histological invasiveness than sporadic adenomas, which results in a higher postoperative recurrence rate and a lower normalization rate of approximately 40% 2) . For this case, close monitoring for tumor growth and metastasis was essential. References: 1) KontogeorgosG Endocrine 2005;27-352) Verges B, et al. J Clin Endocrinol Metab 2002; 87: 457-465. Presentation: No date and time listed" @default.
- W4308133457 created "2022-11-08" @default.
- W4308133457 creator A5001516581 @default.
- W4308133457 creator A5005194109 @default.
- W4308133457 creator A5006626284 @default.
- W4308133457 creator A5021212114 @default.
- W4308133457 creator A5046867279 @default.
- W4308133457 creator A5060578424 @default.
- W4308133457 creator A5067362312 @default.
- W4308133457 creator A5073112205 @default.
- W4308133457 creator A5078843127 @default.
- W4308133457 creator A5079071350 @default.
- W4308133457 creator A5080059155 @default.
- W4308133457 date "2022-11-01" @default.
- W4308133457 modified "2023-10-16" @default.
- W4308133457 title "ODP328 Longitudinal Multidisciplinary Approach for Cabergoline-Resistant Aggressive Prolactinoma Complicated by Multiple Endocrine Neoplasia Type 1" @default.
- W4308133457 doi "https://doi.org/10.1210/jendso/bvac150.1037" @default.
- W4308133457 hasPublicationYear "2022" @default.
- W4308133457 type Work @default.
- W4308133457 citedByCount "0" @default.
- W4308133457 crossrefType "journal-article" @default.
- W4308133457 hasAuthorship W4308133457A5001516581 @default.
- W4308133457 hasAuthorship W4308133457A5005194109 @default.
- W4308133457 hasAuthorship W4308133457A5006626284 @default.
- W4308133457 hasAuthorship W4308133457A5021212114 @default.
- W4308133457 hasAuthorship W4308133457A5046867279 @default.
- W4308133457 hasAuthorship W4308133457A5060578424 @default.
- W4308133457 hasAuthorship W4308133457A5067362312 @default.
- W4308133457 hasAuthorship W4308133457A5073112205 @default.
- W4308133457 hasAuthorship W4308133457A5078843127 @default.
- W4308133457 hasAuthorship W4308133457A5079071350 @default.
- W4308133457 hasAuthorship W4308133457A5080059155 @default.
- W4308133457 hasBestOaLocation W43081334571 @default.
- W4308133457 hasConcept C126322002 @default.
- W4308133457 hasConcept C126838900 @default.
- W4308133457 hasConcept C126894567 @default.
- W4308133457 hasConcept C134018914 @default.
- W4308133457 hasConcept C141071460 @default.
- W4308133457 hasConcept C143409427 @default.
- W4308133457 hasConcept C2776741419 @default.
- W4308133457 hasConcept C2777428134 @default.
- W4308133457 hasConcept C2778918492 @default.
- W4308133457 hasConcept C2779064019 @default.
- W4308133457 hasConcept C2779318953 @default.
- W4308133457 hasConcept C2779832395 @default.
- W4308133457 hasConcept C2781449511 @default.
- W4308133457 hasConcept C46699223 @default.
- W4308133457 hasConcept C71315377 @default.
- W4308133457 hasConcept C71924100 @default.
- W4308133457 hasConcept C90924648 @default.
- W4308133457 hasConceptScore W4308133457C126322002 @default.
- W4308133457 hasConceptScore W4308133457C126838900 @default.
- W4308133457 hasConceptScore W4308133457C126894567 @default.
- W4308133457 hasConceptScore W4308133457C134018914 @default.
- W4308133457 hasConceptScore W4308133457C141071460 @default.
- W4308133457 hasConceptScore W4308133457C143409427 @default.
- W4308133457 hasConceptScore W4308133457C2776741419 @default.
- W4308133457 hasConceptScore W4308133457C2777428134 @default.
- W4308133457 hasConceptScore W4308133457C2778918492 @default.
- W4308133457 hasConceptScore W4308133457C2779064019 @default.
- W4308133457 hasConceptScore W4308133457C2779318953 @default.
- W4308133457 hasConceptScore W4308133457C2779832395 @default.
- W4308133457 hasConceptScore W4308133457C2781449511 @default.
- W4308133457 hasConceptScore W4308133457C46699223 @default.
- W4308133457 hasConceptScore W4308133457C71315377 @default.
- W4308133457 hasConceptScore W4308133457C71924100 @default.
- W4308133457 hasConceptScore W4308133457C90924648 @default.
- W4308133457 hasIssue "Supplement_1" @default.
- W4308133457 hasLocation W43081334571 @default.
- W4308133457 hasLocation W43081334572 @default.
- W4308133457 hasOpenAccess W4308133457 @default.
- W4308133457 hasPrimaryLocation W43081334571 @default.
- W4308133457 hasRelatedWork W1995807783 @default.
- W4308133457 hasRelatedWork W2041989754 @default.
- W4308133457 hasRelatedWork W2047253938 @default.
- W4308133457 hasRelatedWork W2152306407 @default.
- W4308133457 hasRelatedWork W2320810864 @default.
- W4308133457 hasRelatedWork W2423224022 @default.
- W4308133457 hasRelatedWork W2464989290 @default.
- W4308133457 hasRelatedWork W4308133457 @default.
- W4308133457 hasRelatedWork W4308139728 @default.
- W4308133457 hasRelatedWork W2419020410 @default.
- W4308133457 hasVolume "6" @default.
- W4308133457 isParatext "false" @default.
- W4308133457 isRetracted "false" @default.
- W4308133457 workType "article" @default.