FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308133458> ?p ?o ?g. }

• W4308133458 endingPage "A423" @default.
• W4308133458 startingPage "A422" @default.
• W4308133458 abstract "Abstract Cardiovascular morbidity and mortality are high in persons with severe mental illness. Psychotropic medications, particularly second-generation antipsychotics (SGA), and also adverse health behaviors are mediators of adverse cardiometabolic health outcomes in persons with severe mental illness. Identifying and addressing specific risk factors early and aggressively is key to improving health outcomes in these patients; yet studies addressing the above problems are limited. We therefore evaluated 39 patients with schizophrenia, schizoaffective, or bipolar disorder on SGA in a comprehensive cardiometabolic, lifestyle, and mental health screening program. Data were analyzed using SPSS version 24. As previously reported, the majority of screened patients had prediabetes (PD) or diabetes mellitus (DM), 74% per oral Glucose Tolerance Testing (oGTT), 56% per HbA1c criteria. Pulse rates, insulin resistance indices (Homeostatic Model Assessment of Insulin Resistance, HOMA IR, and Matsuda) were significantly different between patients classified as normal or with PD/DM, using either oGTT or HbA1c criteria. However, patients with PD/DM per HbA1c, but not oGTT criterium, also had higher waist/hip ratios (p=0.01), triglyceride (p=0.01) and hsCRP levels (p=0.04) as well as lower HDL levels (p=0.04). We then determined whether dietary habits (by UK Diabetes and Diet Questionnaire, UKDDQ), mood (by Patient Health Questionnaire, PHQ-9) and/or physical activity (average daily step count) were associated with unfavorable, and potentially modifiable cardiometabolic biomarkers (fasting, 2h-oGTT plasma glucose, serum insulin, triglycerides, HDL, LDL, HbA1c, hsCRP and adiponectin). We find that fasting plasma glucose and triglyceride levels significantly correlated with UKDDQ scores (fasting plasma glucose: r=0.34, p=0.03, fasting triglyceride levels: r=0.37, p=0.02); a trend was observed for higher insulin resistance indices (HOMA IR) being associated with higher UKDDQ scores (r=0.31, p=0.06). We also confirm a strong negative correlation of the average daily step count with hsCRP levels (r=-0.62, p&lt;0.0001). PHQ-9 scores negatively correlated with adiponectin levels (r=-0.475, p&lt;0.005). Altogether, in our patient population with severe mental illness on SGA, unhealthy diet habits, low physical activity, and symptoms of depression were associated with higher fasting glucose and triglycerides, higher hsCRP and lower adiponectin levels, all of which may potentially contribute to adverse cardiometabolic outcomes. Future studies should assess the impact of specifically tailored individual lifestyle counseling and medical management interventions in this high-risk patient population. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m., Sunday, June 12, 2022 1:06 p.m. - 1:11 p.m." @default.
• W4308133458 created "2022-11-08" @default.
• W4308133458 creator A5006902635 @default.
• W4308133458 creator A5023438866 @default.
• W4308133458 creator A5027650970 @default.
• W4308133458 creator A5028698153 @default.
• W4308133458 creator A5044887093 @default.
• W4308133458 creator A5060777184 @default.
• W4308133458 creator A5073779933 @default.
• W4308133458 creator A5080654389 @default.
• W4308133458 creator A5036368912 @default.
• W4308133458 date "2022-11-01" @default.
• W4308133458 modified "2023-09-28" @default.
• W4308133458 title "RF16 | PSUN159 Poor Diet Habits, Depression and Low Physical Activity Correlate with Cardiometabolic Risk Markers in Persons with Severe Mental Illness on Second-Generation Antipsychotic Medications." @default.
• W4308133458 doi "https://doi.org/10.1210/jendso/bvac150.879" @default.
• W4308133458 hasPublicationYear "2022" @default.
• W4308133458 type Work @default.
• W4308133458 citedByCount "0" @default.
• W4308133458 crossrefType "journal-article" @default.
• W4308133458 hasAuthorship W4308133458A5006902635 @default.
• W4308133458 hasAuthorship W4308133458A5023438866 @default.
• W4308133458 hasAuthorship W4308133458A5027650970 @default.
• W4308133458 hasAuthorship W4308133458A5028698153 @default.
• W4308133458 hasAuthorship W4308133458A5036368912 @default.
• W4308133458 hasAuthorship W4308133458A5044887093 @default.
• W4308133458 hasAuthorship W4308133458A5060777184 @default.
• W4308133458 hasAuthorship W4308133458A5073779933 @default.
• W4308133458 hasAuthorship W4308133458A5080654389 @default.
• W4308133458 hasBestOaLocation W43081334581 @default.
• W4308133458 hasConcept C118552586 @default.
• W4308133458 hasConcept C126322002 @default.
• W4308133458 hasConcept C134018914 @default.
• W4308133458 hasConcept C2776412080 @default.
• W4308133458 hasConcept C2776782570 @default.
• W4308133458 hasConcept C2777180221 @default.
• W4308133458 hasConcept C2777391703 @default.
• W4308133458 hasConcept C2778163477 @default.
• W4308133458 hasConcept C2778913445 @default.
• W4308133458 hasConcept C2779668308 @default.
• W4308133458 hasConcept C2779727114 @default.
• W4308133458 hasConcept C2780325297 @default.
• W4308133458 hasConcept C2780578515 @default.
• W4308133458 hasConcept C511355011 @default.
• W4308133458 hasConcept C555293320 @default.
• W4308133458 hasConcept C71924100 @default.
• W4308133458 hasConceptScore W4308133458C118552586 @default.
• W4308133458 hasConceptScore W4308133458C126322002 @default.
• W4308133458 hasConceptScore W4308133458C134018914 @default.
• W4308133458 hasConceptScore W4308133458C2776412080 @default.
• W4308133458 hasConceptScore W4308133458C2776782570 @default.
• W4308133458 hasConceptScore W4308133458C2777180221 @default.
• W4308133458 hasConceptScore W4308133458C2777391703 @default.
• W4308133458 hasConceptScore W4308133458C2778163477 @default.
• W4308133458 hasConceptScore W4308133458C2778913445 @default.
• W4308133458 hasConceptScore W4308133458C2779668308 @default.
• W4308133458 hasConceptScore W4308133458C2779727114 @default.
• W4308133458 hasConceptScore W4308133458C2780325297 @default.
• W4308133458 hasConceptScore W4308133458C2780578515 @default.
• W4308133458 hasConceptScore W4308133458C511355011 @default.
• W4308133458 hasConceptScore W4308133458C555293320 @default.
• W4308133458 hasConceptScore W4308133458C71924100 @default.
• W4308133458 hasIssue "Supplement_1" @default.
• W4308133458 hasLocation W43081334581 @default.
• W4308133458 hasOpenAccess W4308133458 @default.
• W4308133458 hasPrimaryLocation W43081334581 @default.
• W4308133458 hasRelatedWork W1988439151 @default.
• W4308133458 hasRelatedWork W1998434356 @default.
• W4308133458 hasRelatedWork W2000536767 @default.
• W4308133458 hasRelatedWork W2035107691 @default.
• W4308133458 hasRelatedWork W2120688902 @default.
• W4308133458 hasRelatedWork W2124038922 @default.
• W4308133458 hasRelatedWork W2136767406 @default.
• W4308133458 hasRelatedWork W2171846156 @default.
• W4308133458 hasRelatedWork W2375944679 @default.
• W4308133458 hasRelatedWork W3028839963 @default.
• W4308133458 hasVolume "6" @default.
• W4308133458 isParatext "false" @default.
• W4308133458 isRetracted "false" @default.
• W4308133458 workType "article" @default.