Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308133683> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4308133683 endingPage "A40" @default.
- W4308133683 startingPage "A39" @default.
- W4308133683 abstract "Abstract Purpose Growth hormone deficiency (GHD) develops early in patients with hypothalamic-pituitary disorder and is frequently accompanied by other anterior pituitary hormone deficiencies including secondary adrenal insufficiency (AI). A growth hormone-releasing peptide-2 (GHRP2), which is wildly used for the diagnosis of patients with GHD, has been considered to induce not only growth hormone (GH) release but also ACTH release. However, its clinical usefulness in hypothalamic-pituitary disorder is unclear. Methods The GHRP2 test, a cosyntropin stimulation test, corticotropin-releasing hormone (CRH) tests and/or insulin tolerance tests (ITTs) were performed on 36 patients having hypothalamic-pituitary disorder. Results Twenty-two (61%) had severe GHD, and 3 (8%) had moderate GHD by GHRP2. There was no difference in baseline ACTH and cortisol between non-GHD, moderate GHD and severe GHD participants. However, a cosyntropin stimulation test and subsequent CRH tests and/or ITTs revealed that 17 (47%) had secondary AI and 16/17 (94%) cases of secondary AI were concomitant with severe GHD. ROC curve analysis demonstrated that the ACTH response in the GHRP2 test was useful for screening pituitary-AI, with a cut-off value of 1.55-fold (83% sensitivity and 88% specificity). Notably, the combination of ACTH response and the peak cortisol level in the GHRP2 test using each cut-off value (1.55-fold and 10 µg/dl, respectively) showed high specificity (100%) with high accuracy (0.94) for diagnosis of pituitary-AI. Conclusion We recommend measuring ACTH as well as GH during the GHRP2 test to avoid overlooking and delays in diagnosis of secondary AI that frequently accompanies GHD. Presentation: No date and time listed" @default.
- W4308133683 created "2022-11-08" @default.
- W4308133683 creator A5007519585 @default.
- W4308133683 creator A5013162238 @default.
- W4308133683 creator A5019445952 @default.
- W4308133683 creator A5041954489 @default.
- W4308133683 creator A5042258522 @default.
- W4308133683 creator A5044916361 @default.
- W4308133683 creator A5049273221 @default.
- W4308133683 creator A5059120963 @default.
- W4308133683 creator A5062310825 @default.
- W4308133683 creator A5079640536 @default.
- W4308133683 creator A5086111840 @default.
- W4308133683 date "2022-11-01" @default.
- W4308133683 modified "2023-09-26" @default.
- W4308133683 title "LBODP006 Clinical Usefulness Of The Growth Hormone-releasing Peptide-2 Test For Hypothalamic-pituitary Disorder" @default.
- W4308133683 doi "https://doi.org/10.1210/jendso/bvac150.082" @default.
- W4308133683 hasPublicationYear "2022" @default.
- W4308133683 type Work @default.
- W4308133683 citedByCount "0" @default.
- W4308133683 crossrefType "journal-article" @default.
- W4308133683 hasAuthorship W4308133683A5007519585 @default.
- W4308133683 hasAuthorship W4308133683A5013162238 @default.
- W4308133683 hasAuthorship W4308133683A5019445952 @default.
- W4308133683 hasAuthorship W4308133683A5041954489 @default.
- W4308133683 hasAuthorship W4308133683A5042258522 @default.
- W4308133683 hasAuthorship W4308133683A5044916361 @default.
- W4308133683 hasAuthorship W4308133683A5049273221 @default.
- W4308133683 hasAuthorship W4308133683A5059120963 @default.
- W4308133683 hasAuthorship W4308133683A5062310825 @default.
- W4308133683 hasAuthorship W4308133683A5079640536 @default.
- W4308133683 hasAuthorship W4308133683A5086111840 @default.
- W4308133683 hasBestOaLocation W43081336831 @default.
- W4308133683 hasConcept C126322002 @default.
- W4308133683 hasConcept C134018914 @default.
- W4308133683 hasConcept C24998067 @default.
- W4308133683 hasConcept C2777391703 @default.
- W4308133683 hasConcept C2778491484 @default.
- W4308133683 hasConcept C2779029589 @default.
- W4308133683 hasConcept C2779113265 @default.
- W4308133683 hasConcept C2779306644 @default.
- W4308133683 hasConcept C2779952775 @default.
- W4308133683 hasConcept C2780546910 @default.
- W4308133683 hasConcept C2908704050 @default.
- W4308133683 hasConcept C2910141127 @default.
- W4308133683 hasConcept C2984496839 @default.
- W4308133683 hasConcept C3017594256 @default.
- W4308133683 hasConcept C71315377 @default.
- W4308133683 hasConcept C71924100 @default.
- W4308133683 hasConcept C76318530 @default.
- W4308133683 hasConceptScore W4308133683C126322002 @default.
- W4308133683 hasConceptScore W4308133683C134018914 @default.
- W4308133683 hasConceptScore W4308133683C24998067 @default.
- W4308133683 hasConceptScore W4308133683C2777391703 @default.
- W4308133683 hasConceptScore W4308133683C2778491484 @default.
- W4308133683 hasConceptScore W4308133683C2779029589 @default.
- W4308133683 hasConceptScore W4308133683C2779113265 @default.
- W4308133683 hasConceptScore W4308133683C2779306644 @default.
- W4308133683 hasConceptScore W4308133683C2779952775 @default.
- W4308133683 hasConceptScore W4308133683C2780546910 @default.
- W4308133683 hasConceptScore W4308133683C2908704050 @default.
- W4308133683 hasConceptScore W4308133683C2910141127 @default.
- W4308133683 hasConceptScore W4308133683C2984496839 @default.
- W4308133683 hasConceptScore W4308133683C3017594256 @default.
- W4308133683 hasConceptScore W4308133683C71315377 @default.
- W4308133683 hasConceptScore W4308133683C71924100 @default.
- W4308133683 hasConceptScore W4308133683C76318530 @default.
- W4308133683 hasIssue "Supplement_1" @default.
- W4308133683 hasLocation W43081336831 @default.
- W4308133683 hasLocation W43081336832 @default.
- W4308133683 hasOpenAccess W4308133683 @default.
- W4308133683 hasPrimaryLocation W43081336831 @default.
- W4308133683 hasRelatedWork W1882097573 @default.
- W4308133683 hasRelatedWork W1972029385 @default.
- W4308133683 hasRelatedWork W2010635678 @default.
- W4308133683 hasRelatedWork W2017965458 @default.
- W4308133683 hasRelatedWork W2092733525 @default.
- W4308133683 hasRelatedWork W2144474281 @default.
- W4308133683 hasRelatedWork W3205011351 @default.
- W4308133683 hasRelatedWork W4238429305 @default.
- W4308133683 hasRelatedWork W4281651105 @default.
- W4308133683 hasRelatedWork W4308133683 @default.
- W4308133683 hasVolume "6" @default.
- W4308133683 isParatext "false" @default.
- W4308133683 isRetracted "false" @default.
- W4308133683 workType "article" @default.