FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308134466> ?p ?o ?g. }

• W4308134466 endingPage "A733" @default.
• W4308134466 startingPage "A733" @default.
• W4308134466 abstract "Abstract Objectives Although 25(OH)D is generally considered the best marker for assessing vitamin D body stores, its role as a marker during acute illness is less well established. Indeed, acute inflammatory insult may reduce circulating 25(OH)D. The objective was to examine serum 25(OH)D levels during the evolution of acute COVID-19 pneumonia. Material and methods: This pilot study was undertaken as a prospective cohort study. Patients with severe COVID-19, defined as clinical signs of pneumonia and respiratory rate &gt; 30 breaths/minute or severe respiratory distress or oxygen saturation &lt; 90% on room air, were admitted to the internal medicine department between 1 November and 31 December. Blood samples were taken on admission (day 0) and every 24 hours for the subsequent four days (days 1-4). Patients were not supplemented with vitamin D preparations during the monitoring period. All patients received 6 milligrams of dexamethasone daily during the monitoring period. Results 22 patients (6 females, 16 males; median age 60.6 years) were included. On admission, 59% of patients were 25(OH)D sufficient (&gt;30 ng/ml), and 41% of patients had 25(OH)D inadequacy (&lt;30 ng/ml) according to the existing guidelines. A significant fall in mean 25(OH)D concentration from admission to day 2 (first 48 h) was observed (30,7 ng/ml vs. 26,4 ng/ml; p&lt;0.0001). No subsequent significant fall in 25(OH)D concentration was observed between day 2 and 3 (26, 4 ng/ml vs. 25,9 ng/ml; p=0.2300) and day 3 and day 4 (25,8 ng/ml vs. 25,9 ng/ml; p=0.7026). The absolute 25(OH)D change between hospital admission and day 4 was 4.8 ng/mL (p&lt;0.0001) and was not associated with mortality or the need for high flow oxygen (p=0.2113 and p=0.6467, respectively). On day 4, the number of patients with 25(OH)D inadequacy (&lt;30 ng/ml) increased by 18% (p=0.0180). Conclusions Serum concentration of 25(OH)D decreases significantly during the first 48 hours after hospital admission in acutely ill COVID-19 patients and should be therefore interpreted with caution. Whether low 25(OH)D in COVID-19 reflects tissue level vitamin D deficiency or represents only a laboratory phenomenon remains to be elucidated in prospective randomized trials of vitamin D supplementation. Presentation: Saturday, June 11, 2022 1:30 p.m. - 1:35 p.m., Monday, June 13, 2022 12:30 p.m. - 2:30 p.m." @default.
• W4308134466 created "2022-11-08" @default.
• W4308134466 creator A5001862342 @default.
• W4308134466 creator A5011627507 @default.
• W4308134466 creator A5035636181 @default.
• W4308134466 creator A5044188040 @default.
• W4308134466 creator A5056041733 @default.
• W4308134466 creator A5070407771 @default.
• W4308134466 creator A5085784756 @default.
• W4308134466 creator A5087190566 @default.
• W4308134466 date "2022-11-01" @default.
• W4308134466 modified "2023-10-17" @default.
• W4308134466 title "RF03 | PMON303 Serum 25-Hydroxyvitamin D Concentration Significantly Decreases in COVID-19 Patients With Pneumonia During the First 48 Hours After Hospital Admission" @default.
• W4308134466 doi "https://doi.org/10.1210/jendso/bvac150.1513" @default.
• W4308134466 hasPublicationYear "2022" @default.
• W4308134466 type Work @default.
• W4308134466 citedByCount "0" @default.
• W4308134466 crossrefType "journal-article" @default.
• W4308134466 hasAuthorship W4308134466A5001862342 @default.
• W4308134466 hasAuthorship W4308134466A5011627507 @default.
• W4308134466 hasAuthorship W4308134466A5035636181 @default.
• W4308134466 hasAuthorship W4308134466A5044188040 @default.
• W4308134466 hasAuthorship W4308134466A5056041733 @default.
• W4308134466 hasAuthorship W4308134466A5070407771 @default.
• W4308134466 hasAuthorship W4308134466A5085784756 @default.
• W4308134466 hasAuthorship W4308134466A5087190566 @default.
• W4308134466 hasBestOaLocation W43081344661 @default.
• W4308134466 hasConcept C124490489 @default.
• W4308134466 hasConcept C126322002 @default.
• W4308134466 hasConcept C141983124 @default.
• W4308134466 hasConcept C188816634 @default.
• W4308134466 hasConcept C2777914695 @default.
• W4308134466 hasConcept C2777953023 @default.
• W4308134466 hasConcept C2779134260 @default.
• W4308134466 hasConcept C2780401358 @default.
• W4308134466 hasConcept C3008058167 @default.
• W4308134466 hasConcept C42219234 @default.
• W4308134466 hasConcept C524204448 @default.
• W4308134466 hasConcept C534529494 @default.
• W4308134466 hasConcept C71924100 @default.
• W4308134466 hasConcept C8213797 @default.
• W4308134466 hasConcept C84393581 @default.
• W4308134466 hasConcept C90924648 @default.
• W4308134466 hasConceptScore W4308134466C124490489 @default.
• W4308134466 hasConceptScore W4308134466C126322002 @default.
• W4308134466 hasConceptScore W4308134466C141983124 @default.
• W4308134466 hasConceptScore W4308134466C188816634 @default.
• W4308134466 hasConceptScore W4308134466C2777914695 @default.
• W4308134466 hasConceptScore W4308134466C2777953023 @default.
• W4308134466 hasConceptScore W4308134466C2779134260 @default.
• W4308134466 hasConceptScore W4308134466C2780401358 @default.
• W4308134466 hasConceptScore W4308134466C3008058167 @default.
• W4308134466 hasConceptScore W4308134466C42219234 @default.
• W4308134466 hasConceptScore W4308134466C524204448 @default.
• W4308134466 hasConceptScore W4308134466C534529494 @default.
• W4308134466 hasConceptScore W4308134466C71924100 @default.
• W4308134466 hasConceptScore W4308134466C8213797 @default.
• W4308134466 hasConceptScore W4308134466C84393581 @default.
• W4308134466 hasConceptScore W4308134466C90924648 @default.
• W4308134466 hasIssue "Supplement_1" @default.
• W4308134466 hasLocation W43081344661 @default.
• W4308134466 hasLocation W43081344662 @default.
• W4308134466 hasOpenAccess W4308134466 @default.
• W4308134466 hasPrimaryLocation W43081344661 @default.
• W4308134466 hasRelatedWork W1978883461 @default.
• W4308134466 hasRelatedWork W1990591567 @default.
• W4308134466 hasRelatedWork W2004154664 @default.
• W4308134466 hasRelatedWork W2009213603 @default.
• W4308134466 hasRelatedWork W2111822674 @default.
• W4308134466 hasRelatedWork W2133791648 @default.
• W4308134466 hasRelatedWork W3029513781 @default.
• W4308134466 hasRelatedWork W3082678732 @default.
• W4308134466 hasRelatedWork W3108559994 @default.
• W4308134466 hasRelatedWork W4293762066 @default.
• W4308134466 hasVolume "6" @default.
• W4308134466 isParatext "false" @default.
• W4308134466 isRetracted "false" @default.
• W4308134466 workType "article" @default.