FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308138338> ?p ?o ?g. }

• W4308138338 endingPage "A636" @default.
• W4308138338 startingPage "A636" @default.
• W4308138338 abstract "Abstract Introduction/Background Type 1 diabetes (T1D) is associated with decreased skeletal muscle mass (SMM) and impaired muscle function in adults. Despite the importance of skeletal muscle in insulin action and metabolic homeostasis, our understanding of skeletal muscle health in children with T1D is very limited. Here we used a novel, non-invasive methodology to compare muscle mass (MM) in children with T1D and sex and age-matched healthy children without diabetes. Objectives We hypothesized that: (a) children with T1D have lower MM than age, sex, and BMI-matched children without T1D; (b) MM in children with T1D correlates with insulin sensitivity and glycemic control. Methods Weight (BW), height, BMI%, body fat% (BF%), daily insulin requirement, CGM data, HbA1c, and total and HMW adiponectin were measured in 24 young children (15 females, 9 males; age 6-11 years) with T1D. BF% and fat-free-mass (FFM) was measured by bioelectrical impedance. Insulin sensitivity was assessed by total and HMW-adiponectin and daily insulin requirements. Glycemic control was assessed by glucose time in range, mean blood glucose, and HbA1c. MM was measured using the D3creatine dilution method in 22 of the children with T1D (14 females, 8 males) and, in a separate study, in 34 children without T1D (17 females and 17 males). This method involves an oral 10 mg dose of deuterated creatine (methyl-d3, D3Cr). Creatine is converted in vivo to creatinine, including D3Cr to D3creatinine, in muscle by an irreversible, nonenzymatic reaction and then excreted. A single fasting urine sample is collected to determine D3creatinine enrichment. MM/BW (%) was calculated to normalize for body weight. Results There were strong positive associations between MM and body weight (r=0.85, p&lt;0.0001), BMI (r=0.61, p=0.0028), and FFM (r=0.72, p=0.0040). Although children with T1D were slightly older (9.2 ±1.3 vs 8.1± 1.2 yo, p=0.003) and had higher BMI (18± 2.3 vs16.0 ±2.0, p=0.001) than controls, they had lower %MM/BW than children without diabetes (37.8± 4.6 vs 43.1±4.5%, p&lt;0.0001). The lower %MM/BW in T1D compared to controls was confirmed in sub-cohorts matched for age and in males and females analyzed separately. Mean daily insulin requirement and HbA1c in the children with T1D were 0.76±0.15 IU/kg/day and 7.1±1.1%, respectively. MM, FFM, %BF, FM, %MM/BW did not correlate with metrics of insulin sensitivity or glycemic control. Conclusions This is the first study to quantitate MM directly in young children with T1D. Our results demonstrate a lower %MM in 6–11-year-old pre-pubertal children with T1D with stable and reasonable glycemic control. The cause for the lower % MM in T1D is not clear; however future studies could examine the rates of muscle protein and fat synthesis and breakdown in healthy and diabetic children along with their relations to insulin administration, metabolic control, growth, and pubertal development. Presentation: Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m." @default.
• W4308138338 created "2022-11-08" @default.
• W4308138338 creator A5006213707 @default.
• W4308138338 creator A5009340130 @default.
• W4308138338 creator A5041993578 @default.
• W4308138338 creator A5046099119 @default.
• W4308138338 creator A5047114493 @default.
• W4308138338 creator A5062134655 @default.
• W4308138338 creator A5080242617 @default.
• W4308138338 creator A5080509236 @default.
• W4308138338 creator A5081964520 @default.
• W4308138338 creator A5089479056 @default.
• W4308138338 date "2022-11-01" @default.
• W4308138338 modified "2023-09-27" @default.
• W4308138338 title "PSAT117 Lower Muscle Mass Relative to Body Weight in Pre-pubertal Children with Type 1 Diabetes" @default.
• W4308138338 doi "https://doi.org/10.1210/jendso/bvac150.1317" @default.
• W4308138338 hasPublicationYear "2022" @default.
• W4308138338 type Work @default.
• W4308138338 citedByCount "0" @default.
• W4308138338 crossrefType "journal-article" @default.
• W4308138338 hasAuthorship W4308138338A5006213707 @default.
• W4308138338 hasAuthorship W4308138338A5009340130 @default.
• W4308138338 hasAuthorship W4308138338A5041993578 @default.
• W4308138338 hasAuthorship W4308138338A5046099119 @default.
• W4308138338 hasAuthorship W4308138338A5047114493 @default.
• W4308138338 hasAuthorship W4308138338A5062134655 @default.
• W4308138338 hasAuthorship W4308138338A5080242617 @default.
• W4308138338 hasAuthorship W4308138338A5080509236 @default.
• W4308138338 hasAuthorship W4308138338A5081964520 @default.
• W4308138338 hasAuthorship W4308138338A5089479056 @default.
• W4308138338 hasBestOaLocation W43081383381 @default.
• W4308138338 hasConcept C126322002 @default.
• W4308138338 hasConcept C134018914 @default.
• W4308138338 hasConcept C2776782570 @default.
• W4308138338 hasConcept C2777391703 @default.
• W4308138338 hasConcept C2779306644 @default.
• W4308138338 hasConcept C2779896295 @default.
• W4308138338 hasConcept C2780221984 @default.
• W4308138338 hasConcept C2780473172 @default.
• W4308138338 hasConcept C2781232474 @default.
• W4308138338 hasConcept C33872192 @default.
• W4308138338 hasConcept C555293320 @default.
• W4308138338 hasConcept C71924100 @default.
• W4308138338 hasConceptScore W4308138338C126322002 @default.
• W4308138338 hasConceptScore W4308138338C134018914 @default.
• W4308138338 hasConceptScore W4308138338C2776782570 @default.
• W4308138338 hasConceptScore W4308138338C2777391703 @default.
• W4308138338 hasConceptScore W4308138338C2779306644 @default.
• W4308138338 hasConceptScore W4308138338C2779896295 @default.
• W4308138338 hasConceptScore W4308138338C2780221984 @default.
• W4308138338 hasConceptScore W4308138338C2780473172 @default.
• W4308138338 hasConceptScore W4308138338C2781232474 @default.
• W4308138338 hasConceptScore W4308138338C33872192 @default.
• W4308138338 hasConceptScore W4308138338C555293320 @default.
• W4308138338 hasConceptScore W4308138338C71924100 @default.
• W4308138338 hasIssue "Supplement_1" @default.
• W4308138338 hasLocation W43081383381 @default.
• W4308138338 hasLocation W43081383382 @default.
• W4308138338 hasOpenAccess W4308138338 @default.
• W4308138338 hasPrimaryLocation W43081383381 @default.
• W4308138338 hasRelatedWork W1988439151 @default.
• W4308138338 hasRelatedWork W2000536767 @default.
• W4308138338 hasRelatedWork W2035107691 @default.
• W4308138338 hasRelatedWork W2096629763 @default.
• W4308138338 hasRelatedWork W2120688902 @default.
• W4308138338 hasRelatedWork W2124038922 @default.
• W4308138338 hasRelatedWork W2136767406 @default.
• W4308138338 hasRelatedWork W2171846156 @default.
• W4308138338 hasRelatedWork W2375944679 @default.
• W4308138338 hasRelatedWork W3028839963 @default.
• W4308138338 hasVolume "6" @default.
• W4308138338 isParatext "false" @default.
• W4308138338 isRetracted "false" @default.
• W4308138338 workType "article" @default.