FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308142102> ?p ?o ?g. }

• W4308142102 endingPage "A70" @default.
• W4308142102 startingPage "A69" @default.
• W4308142102 abstract "Abstract Background The catabolic stress associated with cardiogenic shock requires a robust metabolic, neuroendocrine, and immunologic response to mitigate, and adrenocortical hormones play a huge role in this process. On the other hand, excessive aldosterone production is known to play a key part in the long-term progression of myocardial insufficiency through myocyte remodeling. It is thus intriguing to understand how adrenocortical insufficiency impacts the outcomes of patients admitted for cardiogenic shock. Method: A retrospective cohort study was designed using data obtained from the 2016 to 2018 combined National Inpatient Sample (NIS) database. Adult patients (age &gt;18) with principal admission diagnosis of cardiogenic shock were identified using the international diseases classification code, tenth revision (ICD 10), and separated into two cohorts based on the presence of a secondary diagnosis of adrenal insufficiency. Primary outcomes assessed were, mortality, length of stay (LOS) and total hospital charge. Secondary outcomes evaluated included rate of mechanical ventilation, mechanical circulatory support device use and cardiac arrest. Multivariate linear and logistic regressions were used to adjust for confounders. Results There was a total of 477,695 adult hospitalizations for cardiogenic shock, out of which 1.28% had associated secondary diagnosis of adrenal insufficiency. There was a statistically insignificant increased odds of mortality among patients with adrenal insufficiency (33.42% vs 33.35%, AOR: 1. 05, 95% CI: 0.93 to 1.19, p: 0.462). There was also an increased length of stay (18.91 days vs 11.35 days, adjusted mean difference: 6.5 days, 95%CI: 5.22 days to 7.78 days, p &lt; 0. 001) and an increased total charge (364,864.5 vs 238,591.9 USD, adjusted mean difference: 105,491.9 USD, 95%CI: 78,252.2USD to 132,731.3 USD, p &lt; 0. 001) among patients with adrenal insufficiency compared with the counterpart cohort group and these were statistically significant. Patients with adrenal insufficiency also had 42% increased odds of being mechanically ventilated during cardiogenic shock admission compared to patients without (55.67% vs 46.61%, AOR: 1.42, 95%CI: 1.26 to 1.60, p &lt; 0. 001). Other secondary clinical outcomes assessed, including mechanical circulatory support devices use and cardiac arrest were not statistically different between the two groups. Conclusion Adrenal insufficiency as a comorbid diagnosis among patients admitted with cardiogenic shock was associated with increased odds of requiring mechanical ventilation, prolonged length of stay and higher total hospital charges. There was a trend towards increased mortality, but this was not statistically significant. There was no difference in other clinical outcomes including mechanical circulatory support devices and cardiac arrest rate. Presentation: No date and time listed" @default.
• W4308142102 created "2022-11-08" @default.
• W4308142102 creator A5012331936 @default.
• W4308142102 creator A5042805003 @default.
• W4308142102 creator A5049011895 @default.
• W4308142102 creator A5064445377 @default.
• W4308142102 creator A5077138841 @default.
• W4308142102 creator A5083681418 @default.
• W4308142102 creator A5086017906 @default.
• W4308142102 date "2022-11-01" @default.
• W4308142102 modified "2023-09-23" @default.
• W4308142102 title "ODP065 Impact of Comorbid Adrenal Insufficiency on Outcomes During Hospitalization For Cardiogenic Shock" @default.
• W4308142102 doi "https://doi.org/10.1210/jendso/bvac150.144" @default.
• W4308142102 hasPublicationYear "2022" @default.
• W4308142102 type Work @default.
• W4308142102 citedByCount "0" @default.
• W4308142102 crossrefType "journal-article" @default.
• W4308142102 hasAuthorship W4308142102A5012331936 @default.
• W4308142102 hasAuthorship W4308142102A5042805003 @default.
• W4308142102 hasAuthorship W4308142102A5049011895 @default.
• W4308142102 hasAuthorship W4308142102A5064445377 @default.
• W4308142102 hasAuthorship W4308142102A5077138841 @default.
• W4308142102 hasAuthorship W4308142102A5083681418 @default.
• W4308142102 hasAuthorship W4308142102A5086017906 @default.
• W4308142102 hasBestOaLocation W43081421022 @default.
• W4308142102 hasConcept C126322002 @default.
• W4308142102 hasConcept C156957248 @default.
• W4308142102 hasConcept C164705383 @default.
• W4308142102 hasConcept C167135981 @default.
• W4308142102 hasConcept C2776850375 @default.
• W4308142102 hasConcept C2778129406 @default.
• W4308142102 hasConcept C2781300812 @default.
• W4308142102 hasConcept C2911038130 @default.
• W4308142102 hasConcept C41008148 @default.
• W4308142102 hasConcept C500558357 @default.
• W4308142102 hasConcept C71924100 @default.
• W4308142102 hasConcept C72563966 @default.
• W4308142102 hasConcept C77088390 @default.
• W4308142102 hasConcept C77350462 @default.
• W4308142102 hasConceptScore W4308142102C126322002 @default.
• W4308142102 hasConceptScore W4308142102C156957248 @default.
• W4308142102 hasConceptScore W4308142102C164705383 @default.
• W4308142102 hasConceptScore W4308142102C167135981 @default.
• W4308142102 hasConceptScore W4308142102C2776850375 @default.
• W4308142102 hasConceptScore W4308142102C2778129406 @default.
• W4308142102 hasConceptScore W4308142102C2781300812 @default.
• W4308142102 hasConceptScore W4308142102C2911038130 @default.
• W4308142102 hasConceptScore W4308142102C41008148 @default.
• W4308142102 hasConceptScore W4308142102C500558357 @default.
• W4308142102 hasConceptScore W4308142102C71924100 @default.
• W4308142102 hasConceptScore W4308142102C72563966 @default.
• W4308142102 hasConceptScore W4308142102C77088390 @default.
• W4308142102 hasConceptScore W4308142102C77350462 @default.
• W4308142102 hasIssue "Supplement_1" @default.
• W4308142102 hasLocation W43081421021 @default.
• W4308142102 hasLocation W43081421022 @default.
• W4308142102 hasOpenAccess W4308142102 @default.
• W4308142102 hasPrimaryLocation W43081421021 @default.
• W4308142102 hasRelatedWork W1970200859 @default.
• W4308142102 hasRelatedWork W1971159013 @default.
• W4308142102 hasRelatedWork W1981171782 @default.
• W4308142102 hasRelatedWork W2044684004 @default.
• W4308142102 hasRelatedWork W2051606144 @default.
• W4308142102 hasRelatedWork W2077500059 @default.
• W4308142102 hasRelatedWork W2078224059 @default.
• W4308142102 hasRelatedWork W2197020648 @default.
• W4308142102 hasRelatedWork W2278380801 @default.
• W4308142102 hasRelatedWork W4308142102 @default.
• W4308142102 hasVolume "6" @default.
• W4308142102 isParatext "false" @default.
• W4308142102 isRetracted "false" @default.
• W4308142102 workType "article" @default.