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- W4308142711 abstract "Animal welfare assessment relies on valid and practical indicators of affect. In mice, the most widely used research vertebrates, lying still with eyes open, inactive-but-awake (IBA) in the home cage, has potential to be one such indicator. IBA is elevated in barren, conventional housing compared with well-resourced, enriched housing, and predicts immobility in Forced Swim Tests, a common measure of ‘helplessness’ in depression research. In Experiment 1, using females from three strains (C57BL/6, Balb/c and DBA/2), we first replicated past findings, confirming higher levels of IBA in conventional cages and a positive relationship between IBA and helplessness. We then extended this research to three other signs of depression: changes in weight and sleep, and reduced hippocampal volume. Here, IBA positively covaried with body mass index, with sleep in DBA/2s and conventionally housed BALB/cs, and negatively covaried with hippocampal volume in conventionally housed C57BL/6s. In Experiment 2, we sought to refine the phenotype of IBA to improve its accuracy as a welfare indicator. Here, scoring IBA performed in hunched postures appeared to improve its accuracy as an indicator in Balb/c mice. Additional research is now needed to further refine the phenotype of IBA and to confirm whether it reflects states consistent with depression, or instead other underlying poor welfare conditions." @default.
- W4308142711 created "2022-11-08" @default.
- W4308142711 creator A5010915639 @default.
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- W4308142711 date "2022-11-01" @default.
- W4308142711 modified "2023-09-30" @default.
- W4308142711 title "Waking inactivity as a welfare indicator in laboratory mice: investigating postures, facial expressions and depression-like states" @default.
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- W4308142711 doi "https://doi.org/10.1098/rsos.221083" @default.
- W4308142711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36340516" @default.
- W4308142711 hasPublicationYear "2022" @default.
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