Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308147461> ?p ?o ?g. }
- W4308147461 endingPage "428" @default.
- W4308147461 startingPage "421" @default.
- W4308147461 abstract "Lipid nanoparticles (LNPs) are currently the most advanced non-viral clinically approved messenger ribonucleic acid (mRNA) delivery systems. The ability of a mRNA vaccine to have a therapeutic effect is related to the capacity of LNPs to deliver the nucleic acid intact into cells. The role of LNPs is to protect mRNA, especially from degradation by ribonucleases (RNases) and to allow it to access the cytoplasm of cells where it can be translated into the protein of interest. LNPs enter cells by endocytosis and their size is a critical parameter impacting their cellular internalization. In this work, we studied different formulation process parameters impacting LNPs size. Taylor dispersion analysis (TDA) was used to determine the LNPs size and size distribution and the results were compared with those obtained by Dynamic Light Scattering (DLS). TDA was also used to study both the degradation of mRNA in the presence of RNases and the percentage of mRNA encapsulation within LNPs." @default.
- W4308147461 created "2022-11-08" @default.
- W4308147461 creator A5010675967 @default.
- W4308147461 creator A5020124312 @default.
- W4308147461 creator A5027032645 @default.
- W4308147461 creator A5049311651 @default.
- W4308147461 creator A5064861272 @default.
- W4308147461 creator A5069066211 @default.
- W4308147461 creator A5070189408 @default.
- W4308147461 date "2022-11-01" @default.
- W4308147461 modified "2023-10-18" @default.
- W4308147461 title "Taylor Dispersion Analysis to support lipid-nanoparticle formulations for mRNA vaccines" @default.
- W4308147461 cites W1973544083 @default.
- W4308147461 cites W1975088956 @default.
- W4308147461 cites W1987406340 @default.
- W4308147461 cites W1998837709 @default.
- W4308147461 cites W2011784577 @default.
- W4308147461 cites W2014495927 @default.
- W4308147461 cites W2051913120 @default.
- W4308147461 cites W2113972541 @default.
- W4308147461 cites W2117824758 @default.
- W4308147461 cites W2125470506 @default.
- W4308147461 cites W2143463421 @default.
- W4308147461 cites W2152366705 @default.
- W4308147461 cites W2155239981 @default.
- W4308147461 cites W2167806590 @default.
- W4308147461 cites W2171083652 @default.
- W4308147461 cites W2204416339 @default.
- W4308147461 cites W2279560840 @default.
- W4308147461 cites W2284745064 @default.
- W4308147461 cites W2340049980 @default.
- W4308147461 cites W2340662778 @default.
- W4308147461 cites W2344644350 @default.
- W4308147461 cites W2573033399 @default.
- W4308147461 cites W2754401101 @default.
- W4308147461 cites W2765754868 @default.
- W4308147461 cites W2767808903 @default.
- W4308147461 cites W2782708334 @default.
- W4308147461 cites W2791854174 @default.
- W4308147461 cites W2794867971 @default.
- W4308147461 cites W2799813152 @default.
- W4308147461 cites W2800718878 @default.
- W4308147461 cites W2936171216 @default.
- W4308147461 cites W2941434812 @default.
- W4308147461 cites W2990014136 @default.
- W4308147461 cites W2992823069 @default.
- W4308147461 cites W2993162569 @default.
- W4308147461 cites W3003603323 @default.
- W4308147461 cites W3015140168 @default.
- W4308147461 cites W3023791804 @default.
- W4308147461 cites W3046633757 @default.
- W4308147461 cites W3048467449 @default.
- W4308147461 cites W3048531412 @default.
- W4308147461 cites W3087200179 @default.
- W4308147461 cites W3088467904 @default.
- W4308147461 cites W3103321439 @default.
- W4308147461 cites W3109746568 @default.
- W4308147461 cites W3110973116 @default.
- W4308147461 cites W3113774549 @default.
- W4308147461 cites W3137746616 @default.
- W4308147461 cites W3148255637 @default.
- W4308147461 cites W3148644681 @default.
- W4308147461 cites W3149478899 @default.
- W4308147461 cites W3156499758 @default.
- W4308147461 cites W3164966659 @default.
- W4308147461 cites W3171238035 @default.
- W4308147461 cites W4205094190 @default.
- W4308147461 cites W4221022417 @default.
- W4308147461 cites W4253670085 @default.
- W4308147461 doi "https://doi.org/10.1038/s41434-022-00370-1" @default.
- W4308147461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36316446" @default.
- W4308147461 hasPublicationYear "2022" @default.
- W4308147461 type Work @default.
- W4308147461 citedByCount "0" @default.
- W4308147461 crossrefType "journal-article" @default.
- W4308147461 hasAuthorship W4308147461A5010675967 @default.
- W4308147461 hasAuthorship W4308147461A5020124312 @default.
- W4308147461 hasAuthorship W4308147461A5027032645 @default.
- W4308147461 hasAuthorship W4308147461A5049311651 @default.
- W4308147461 hasAuthorship W4308147461A5064861272 @default.
- W4308147461 hasAuthorship W4308147461A5069066211 @default.
- W4308147461 hasAuthorship W4308147461A5070189408 @default.
- W4308147461 hasBestOaLocation W43081474611 @default.
- W4308147461 hasConcept C104317684 @default.
- W4308147461 hasConcept C105580179 @default.
- W4308147461 hasConcept C12554922 @default.
- W4308147461 hasConcept C139770010 @default.
- W4308147461 hasConcept C1491633281 @default.
- W4308147461 hasConcept C153911025 @default.
- W4308147461 hasConcept C190062978 @default.
- W4308147461 hasConcept C24107716 @default.
- W4308147461 hasConcept C28005876 @default.
- W4308147461 hasConcept C55493867 @default.
- W4308147461 hasConcept C67705224 @default.
- W4308147461 hasConcept C86803240 @default.
- W4308147461 hasConcept C95444343 @default.
- W4308147461 hasConceptScore W4308147461C104317684 @default.
- W4308147461 hasConceptScore W4308147461C105580179 @default.