FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308149935> ?p ?o ?g. }

• W4308149935 endingPage "3533" @default.
• W4308149935 startingPage "3513" @default.
• W4308149935 abstract "Genome-wide association studies and functional genomics studies have linked specific cell types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles primarily affect the abundance or structure, and thus the activity, of genes expressed in macrophages, strongly implicating microglia (the brain-resident macrophages) in the etiology of AD. These genes converge on pathways (endocytosis/phagocytosis, cholesterol metabolism, and immune response) with critical roles in core macrophage functions such as efferocytosis. Here, we review these pathways, highlighting relevant genes identified in the latest AD genetics and genomics studies, and describe how they may contribute to AD pathogenesis. Investigating the functional impact of AD-associated variants and genes in microglia is essential for elucidating disease risk mechanisms and developing effective therapeutic approaches." @default.
• W4308149935 created "2022-11-08" @default.
• W4308149935 creator A5000475810 @default.
• W4308149935 creator A5012875579 @default.
• W4308149935 creator A5017017613 @default.
• W4308149935 creator A5027004714 @default.
• W4308149935 creator A5040692198 @default.
• W4308149935 date "2022-11-01" @default.
• W4308149935 modified "2023-10-16" @default.
• W4308149935 title "Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool" @default.
• W4308149935 cites W1606221841 @default.
• W4308149935 cites W1689692388 @default.
• W4308149935 cites W1844405070 @default.
• W4308149935 cites W1967434989 @default.
• W4308149935 cites W1968521853 @default.
• W4308149935 cites W1973543655 @default.
• W4308149935 cites W1980789245 @default.
• W4308149935 cites W1983619827 @default.
• W4308149935 cites W1984737558 @default.
• W4308149935 cites W1987618579 @default.
• W4308149935 cites W1991826273 @default.
• W4308149935 cites W1996457468 @default.
• W4308149935 cites W2010696236 @default.
• W4308149935 cites W2011041653 @default.
• W4308149935 cites W2011906296 @default.
• W4308149935 cites W2013111251 @default.
• W4308149935 cites W2014704142 @default.
• W4308149935 cites W2017867302 @default.
• W4308149935 cites W2021539595 @default.
• W4308149935 cites W2026279003 @default.
• W4308149935 cites W2027460468 @default.
• W4308149935 cites W2033883349 @default.
• W4308149935 cites W2036362108 @default.
• W4308149935 cites W2040912634 @default.
• W4308149935 cites W2043834857 @default.
• W4308149935 cites W2045548994 @default.
• W4308149935 cites W2053365501 @default.
• W4308149935 cites W2053976302 @default.
• W4308149935 cites W2058803120 @default.
• W4308149935 cites W2058880763 @default.
• W4308149935 cites W2060814715 @default.
• W4308149935 cites W2061905787 @default.
• W4308149935 cites W2066250017 @default.
• W4308149935 cites W2072462631 @default.
• W4308149935 cites W2077588880 @default.
• W4308149935 cites W2078059415 @default.
• W4308149935 cites W2081014274 @default.
• W4308149935 cites W2081250995 @default.
• W4308149935 cites W2081854936 @default.
• W4308149935 cites W2091540470 @default.
• W4308149935 cites W2091901410 @default.
• W4308149935 cites W2092339616 @default.
• W4308149935 cites W2092508662 @default.
• W4308149935 cites W2093124229 @default.
• W4308149935 cites W2097138052 @default.
• W4308149935 cites W2101280135 @default.
• W4308149935 cites W2102416906 @default.
• W4308149935 cites W2106979652 @default.
• W4308149935 cites W2107094473 @default.
• W4308149935 cites W2108629610 @default.
• W4308149935 cites W2111289935 @default.
• W4308149935 cites W2113521043 @default.
• W4308149935 cites W2115779804 @default.
• W4308149935 cites W2118626656 @default.
• W4308149935 cites W2123056267 @default.
• W4308149935 cites W2124927590 @default.
• W4308149935 cites W2126811287 @default.
• W4308149935 cites W2128094952 @default.
• W4308149935 cites W2136123169 @default.
• W4308149935 cites W2138657570 @default.
• W4308149935 cites W2139597684 @default.
• W4308149935 cites W2139703556 @default.
• W4308149935 cites W2140259754 @default.
• W4308149935 cites W2142222850 @default.
• W4308149935 cites W2143282831 @default.
• W4308149935 cites W2145854562 @default.
• W4308149935 cites W2155602575 @default.
• W4308149935 cites W2156421803 @default.
• W4308149935 cites W2160779535 @default.
• W4308149935 cites W2166511841 @default.
• W4308149935 cites W2167693778 @default.
• W4308149935 cites W2168312688 @default.
• W4308149935 cites W2170107264 @default.
• W4308149935 cites W2194170515 @default.
• W4308149935 cites W2220698190 @default.
• W4308149935 cites W2314634699 @default.
• W4308149935 cites W2341088037 @default.
• W4308149935 cites W2345827332 @default.
• W4308149935 cites W2406818379 @default.
• W4308149935 cites W2439312023 @default.
• W4308149935 cites W2482717739 @default.
• W4308149935 cites W2514110735 @default.
• W4308149935 cites W2520459152 @default.
• W4308149935 cites W2575618123 @default.
• W4308149935 cites W2592518050 @default.
• W4308149935 cites W2598984514 @default.
• W4308149935 cites W2601986670 @default.
• W4308149935 cites W2618913695 @default.

• next