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• W4308152124 abstract "Growth factors (GFs) have a wide range of biological functions and are used in tissue engineering due to their ability to induce functional regeneration. However, their potential is yet to be fully realised and the translation of exciting in vitro data to the clinic remains a challenge. GFs are unstable in vivo with unwanted, off-target effects often reported. Incorporating GFs into hydrogels can improve the efficacy of GFs by protecting their function and sustaining their presence in the body, all while targeting certain tissues. This review provides insight into the formation of GF-loaded hydrogels, alongside key properties of these systems, including loading and release kinetics of the GFs. For this field to advance, in vivo performance of the GF-loaded hydrogels and in vivo efficacy of the GFs must be considered. There is a small but growing body of data surrounding these critical points which is critically reviewed in this article. Hydrogels hold great promise to present stable and bioactive GFs to target tissues for tissue engineering applications, and through consideration of in vivo effects alongside clinical needs more of these systems will be translated in the future." @default.
• W4308152124 created "2022-11-08" @default.
• W4308152124 creator A5014208169 @default.
• W4308152124 creator A5046913723 @default.
• W4308152124 creator A5066869857 @default.
• W4308152124 date "2022-12-01" @default.
• W4308152124 modified "2023-10-16" @default.
• W4308152124 title "Hydrogels can control the presentation of growth factors and thereby improve their efficacy in tissue engineering" @default.
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