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- W4308154480 abstract "Recurrent pregnancy loss (RPL) is defined as at least three consecutive pregnancies ending in a miscarriage. RPL affects around 1–3% of child-bearing couples. In up to half of cases the etiology of RPL cannot be identified; many such cases are believed to be caused by alterations of the mechanisms involved in the development of immune tolerance of the fetus as a semi-allograft. One of the key proteins involved in the regulation of the immune system during pregnancy is progesterone-induced blocking factor (PIBF). Here we present our hypothesis according to which recombinant PIBF could be used in the treatment of immune system-mediated RPL. An alternative to PIBF could be interleukin (IL)-4; the rationale for the use of IL-4 in RPL is that immunomodulatory effects of PIBF are mediated by α subunit of IL-4 receptor. Both PIBF and IL-4 exert some immunomodulatory effects that could be beneficial in patients with RPL." @default.
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- W4308154480 date "2022-11-01" @default.
- W4308154480 modified "2023-09-29" @default.
- W4308154480 title "Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss" @default.
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- W4308154480 doi "https://doi.org/10.1016/j.mehy.2022.110968" @default.
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