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- W4308156601 endingPage "105469" @default.
- W4308156601 startingPage "105469" @default.
- W4308156601 abstract "A detailed understanding of the developmental substates of human pluripotent stem cells (hPSCs) is needed to optimize their use in cell therapy and for modeling early development. Genetic instability and risk of tumorigenicity of primed hPSCs are well documented, but a systematic isogenic comparison between substates has not been performed. We derived four hESC lines in naive human stem cell medium (NHSM) and generated isogenic pairs of NHSM and primed cultures. Through phenotypic, transcriptomic, and methylation profiling, we identified changes that arose during the transition to a primed substate. Although early NHSM cultures displayed naive characteristics, including greater proliferation and clonogenic potential compared with primed cultures, they drifted toward a more primed-like substate over time, including accumulation of genetic abnormalities. Overall, we show that transcriptomic and epigenomic profiling can be used to place human pluripotent cultures along a developmental continuum and may inform their utility for clinical and research applications." @default.
- W4308156601 created "2022-11-08" @default.
- W4308156601 creator A5015176968 @default.
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- W4308156601 creator A5042826075 @default.
- W4308156601 creator A5046152857 @default.
- W4308156601 creator A5058320505 @default.
- W4308156601 creator A5068000297 @default.
- W4308156601 date "2022-12-01" @default.
- W4308156601 modified "2023-10-14" @default.
- W4308156601 title "Stabilization of hESCs in two distinct substates along the continuum of pluripotency" @default.
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