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- W4308156625 abstract "The conjugative pilus expression (Cpx) stress response system can sense cell envelope stressors, such as misfolded proteins, and upregulate proteases to modify or degrade damaged proteins. YihE is a protein kinase implicated in the Cpx system, and Rho is a transcription termination factor in prokaryotes, but no functional connection between YihE and Rho has been reported. Here, we found that YihE can interact with Rho to form a binary complex with a stoichiometric ratio of 6:1 (Rho:YihE). A low resolution of Rho crystal structure in the presence of YihE was determined. YihE overexpression helped lessen the aberrant effects caused by Rho overexpression, including long cell morphology and other Rho-mediated phenotypes. Overall, YihE is a Rho binding partner that acts as a Rho antagonist in the Cpx stress. YihE binding to Rho would compete RNA from binding to Rho, thereby helping bacteria cope with stress through the regulation of Rho-dependent transcription termination." @default.
- W4308156625 created "2022-11-08" @default.
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- W4308156625 date "2022-12-01" @default.
- W4308156625 modified "2023-10-18" @default.
- W4308156625 title "YihE is a novel binding partner of Rho and regulates Rho-dependent transcription termination in the Cpx stress response" @default.
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- W4308156625 doi "https://doi.org/10.1016/j.isci.2022.105483" @default.
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