FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308156779> ?p ?o ?g. }

• W4308156779 endingPage "109340" @default.
• W4308156779 startingPage "109340" @default.
• W4308156779 abstract "Osteoarthritis (OA) is a complex chronic inflammatory disease characterized by articular degeneration and pain. Recent studies have identified interleukin 6 (IL-6) as a potential mediator leading to OA, but the therapeutic effects of inhibiting IL-6 signaling in intreating OA need to be further clarified. Here, we identified the intracellular signal transduction induced by recombinant IL-6 and focused on the impact of tyrphostin AG490 (a JAK2 inhibitor) on cartilage degeneration and OA pain. We found that IL-6 increased the inflammatory cytokines production and hypertrophic markers expression of primary mouse chondrocytes by activating JAK2/STAT3. Meanwhile, tyrphostin AG490 significantly attenuated articular degeneration and osteophyte formation in experimental mice with anterior cruciate ligament transection (ACLT) surgery. In vivo electrophysiological experiments showed that articular stimulation of IL-6 induced spinal hyperexcitability, which was prevented by coinjection of tyrphostin AG490. Specifically, compared with DMSO-treated ACLT mice, tyrphostin AG490 improved ambulate activity of mice and abolished the enhancement of serum bradykinin induced by IL-6. Together, we suggest that tyrphostin AG490 protected against progression of OA and improved OA prognosis by reducing cartilage degeneration and arthritis pain. Our findings provide further evidence for targeting IL-6 signaling in the treatment of OA." @default.
• W4308156779 created "2022-11-08" @default.
• W4308156779 creator A5007145349 @default.
• W4308156779 creator A5009252446 @default.
• W4308156779 creator A5009791505 @default.
• W4308156779 creator A5011926050 @default.
• W4308156779 creator A5026906414 @default.
• W4308156779 creator A5057370229 @default.
• W4308156779 creator A5063088081 @default.
• W4308156779 creator A5063697410 @default.
• W4308156779 creator A5072826155 @default.
• W4308156779 creator A5078462758 @default.
• W4308156779 creator A5079594267 @default.
• W4308156779 date "2022-12-01" @default.
• W4308156779 modified "2023-10-01" @default.
• W4308156779 title "Blockade of JAK2 retards cartilage degeneration and IL-6-induced pain amplification in osteoarthritis" @default.
• W4308156779 cites W1514421950 @default.
• W4308156779 cites W1894169931 @default.
• W4308156779 cites W1988209540 @default.
• W4308156779 cites W2008430756 @default.
• W4308156779 cites W2009524387 @default.
• W4308156779 cites W2012375609 @default.
• W4308156779 cites W2017700873 @default.
• W4308156779 cites W2022228053 @default.
• W4308156779 cites W2027831505 @default.
• W4308156779 cites W2027845229 @default.
• W4308156779 cites W2029960175 @default.
• W4308156779 cites W2035618305 @default.
• W4308156779 cites W2038773696 @default.
• W4308156779 cites W2063924458 @default.
• W4308156779 cites W2072304718 @default.
• W4308156779 cites W2078841246 @default.
• W4308156779 cites W2086840459 @default.
• W4308156779 cites W2088306841 @default.
• W4308156779 cites W2099311633 @default.
• W4308156779 cites W2103495251 @default.
• W4308156779 cites W2106417432 @default.
• W4308156779 cites W2110598751 @default.
• W4308156779 cites W2113670619 @default.
• W4308156779 cites W2130410032 @default.
• W4308156779 cites W2146512944 @default.
• W4308156779 cites W2317124801 @default.
• W4308156779 cites W2544192525 @default.
• W4308156779 cites W2560106899 @default.
• W4308156779 cites W2599956086 @default.
• W4308156779 cites W2607911811 @default.
• W4308156779 cites W2609354761 @default.
• W4308156779 cites W2781654755 @default.
• W4308156779 cites W2786987313 @default.
• W4308156779 cites W2803975545 @default.
• W4308156779 cites W2883019022 @default.
• W4308156779 cites W2889131448 @default.
• W4308156779 cites W2923746368 @default.
• W4308156779 cites W2936183454 @default.
• W4308156779 cites W2955666772 @default.
• W4308156779 cites W2972428846 @default.
• W4308156779 cites W2973485974 @default.
• W4308156779 cites W2976137416 @default.
• W4308156779 cites W2996774074 @default.
• W4308156779 cites W3014070799 @default.
• W4308156779 cites W3044656313 @default.
• W4308156779 cites W3085095620 @default.
• W4308156779 cites W3092910273 @default.
• W4308156779 cites W3154072441 @default.
• W4308156779 cites W3182849920 @default.
• W4308156779 cites W4211069396 @default.
• W4308156779 cites W4238640554 @default.
• W4308156779 doi "https://doi.org/10.1016/j.intimp.2022.109340" @default.
• W4308156779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36330910" @default.
• W4308156779 hasPublicationYear "2022" @default.
• W4308156779 type Work @default.
• W4308156779 citedByCount "3" @default.
• W4308156779 countsByYear W43081567792023 @default.
• W4308156779 crossrefType "journal-article" @default.
• W4308156779 hasAuthorship W4308156779A5007145349 @default.
• W4308156779 hasAuthorship W4308156779A5009252446 @default.
• W4308156779 hasAuthorship W4308156779A5009791505 @default.
• W4308156779 hasAuthorship W4308156779A5011926050 @default.
• W4308156779 hasAuthorship W4308156779A5026906414 @default.
• W4308156779 hasAuthorship W4308156779A5057370229 @default.
• W4308156779 hasAuthorship W4308156779A5063088081 @default.
• W4308156779 hasAuthorship W4308156779A5063697410 @default.
• W4308156779 hasAuthorship W4308156779A5072826155 @default.
• W4308156779 hasAuthorship W4308156779A5078462758 @default.
• W4308156779 hasAuthorship W4308156779A5079594267 @default.
• W4308156779 hasConcept C105702510 @default.
• W4308156779 hasConcept C126322002 @default.
• W4308156779 hasConcept C142724271 @default.
• W4308156779 hasConcept C204787440 @default.
• W4308156779 hasConcept C2776164576 @default.
• W4308156779 hasConcept C2779354088 @default.
• W4308156779 hasConcept C2780550940 @default.
• W4308156779 hasConcept C502942594 @default.
• W4308156779 hasConcept C71924100 @default.
• W4308156779 hasConceptScore W4308156779C105702510 @default.
• W4308156779 hasConceptScore W4308156779C126322002 @default.
• W4308156779 hasConceptScore W4308156779C142724271 @default.
• W4308156779 hasConceptScore W4308156779C204787440 @default.

• next