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• W4308157440 endingPage "184081" @default.
• W4308157440 startingPage "184081" @default.
• W4308157440 abstract "Carotenoids play an important role in the protection of biomembranes against oxidative damage. Their function depends on the surroundings and the organization of the lipid membrane they are embedded in. Carotenoids are located parallel or perpendicular to the surface of the lipid bilayer. The influence of carotenoids on the organization of the lipid bilayer in the stratum corneum has not been thoroughly considered. Here, the orientation of the exemplary cutaneous carotenoids lycopene and zeaxanthin in a hydrated ceramide NS24 bilayer model and the influence of carotenoids on the lateral organization of the lipid bilayer model were studied by means of molecular dynamics simulations for 32 °C and 37 °C. The results confirm that lycopene is located parallel and zeaxanthin perpendicular to the surface of the lipid bilayer. The lycopene-loaded lipid bilayer appeared to have a strong orthorhombic organization, while zeaxanthin-loaded and pure lipid bilayers were organized in a disordered hexagonal-like and liquid-like state, respectively. The effect is stronger at 32 °C compared to 37 °C based on p-values. Therefore, it was assumed that carotenoids without hydroxyl polar groups in their structure facilitate the formation of the orthorhombic organization of lipids, which provides the skin barrier function. It was shown that the distance between carotenoid atoms matched the distance between atoms in the lipids, indicating that parallel located carotenoids without hydroxyl groups serve as a skeleton for lipid membranes inside the lamellae. The obtained results provide reasonable prediction of the overall qualitative properties of lipid model systems and show the importance of parallel-oriented carotenoids in the development and maintenance of the skin barrier function." @default.
• W4308157440 created "2022-11-08" @default.
• W4308157440 creator A5016806521 @default.
• W4308157440 creator A5026660191 @default.
• W4308157440 creator A5029307016 @default.
• W4308157440 creator A5045770395 @default.
• W4308157440 creator A5059628938 @default.
• W4308157440 creator A5063672435 @default.
• W4308157440 creator A5084652371 @default.
• W4308157440 creator A5085365866 @default.
• W4308157440 date "2023-01-01" @default.
• W4308157440 modified "2023-10-05" @default.
• W4308157440 title "Lycopene, but not zeaxanthin, serves as a skeleton for the formation of an orthorhombic organization of intercellular lipids within the lamellae in the stratum corneum: Molecular dynamics simulations of the hydrated ceramide NS bilayer model" @default.
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