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- W4308165701 endingPage "12841" @default.
- W4308165701 startingPage "12841" @default.
- W4308165701 abstract "Alzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer’s brain. These proteins are highly expressed in nerve cells and found in most tissues. Tau primarily provides stabilization to microtubules in the part of axons and dendrites. However, tau in a pathological state becomes hyperphosphorylated, causing tau dysfunction and leading to synaptic impairment and degeneration of neurons. This article presents a summary of the role of tau, phosphorylated tau (p-tau) in AD, and other tauopathies. Tauopathies, including Pick’s disease, frontotemporal dementia, corticobasal degeneration, Alzheimer’s disease, argyrophilic grain disease, progressive supranuclear palsy, and Huntington’s disease, are the result of misprocessing and accumulation of tau within the neuronal and glial cells. This article also focuses on current research on the post-translational modifications and genetics of tau, tau pathology, the role of tau in tauopathies and the development of new drugs targeting p-tau, and the therapeutics for treating and possibly preventing tauopathies." @default.
- W4308165701 created "2022-11-08" @default.
- W4308165701 creator A5034947570 @default.
- W4308165701 creator A5036285371 @default.
- W4308165701 creator A5051965950 @default.
- W4308165701 creator A5073424154 @default.
- W4308165701 creator A5084673116 @default.
- W4308165701 creator A5089190222 @default.
- W4308165701 date "2022-10-25" @default.
- W4308165701 modified "2023-10-17" @default.
- W4308165701 title "Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies" @default.
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