Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308178002> ?p ?o ?g. }
- W4308178002 endingPage "2209466" @default.
- W4308178002 startingPage "2209466" @default.
- W4308178002 abstract "Effective therapies capable of simultaneously inhibiting inflammation and promoting bone healing remain to be developed for inflammatory bone disease. Stem cell therapies hold great promise for a variety of diseases, but their translation is hampered by low cell survival, rapid clearance, and limited functional integration of transplanted stem cells in target tissues. Herein, a multifunctional hydrogel-based stem cell niche engineering strategy is reported for the treatment of inflammatory bone loss. By rationally integrating different functional modules, an injectable hydrogel-based stem niche is engineered, which possesses temperature-triggered gelling performance, inflammation/oxidative stress-resolving activity, stem-cell binding and survival-enhancing capacity, and osteogenesis-promoting capability. Using ectomesenchymal stem cells (EMSCs), effectiveness of this functionally advanced synthetic stem cell niche is demonstrated in rats with periodontitis, a representative inflammatory bone loss disease. Synergistic effects of the multifunctional hydrogel and EMSCs are also confirmed, with respect to normalizing the pathological microenvironment and improving alveolar bone regeneration in the periodontal tissue. Mechanistically, inflammation/oxidative stress-resolving and osteogenic differentiation promoting capacities of the synthetic stem cell niche are mainly achieved by an incorporated nanotherapy via the GDF15/Atf3/c-Fos axis of the MAPK signaling pathway. Besides periodontitis, the newly engineered hydrogel-stem cell therapies are promising for the treatment of other inflammatory bone defects." @default.
- W4308178002 created "2022-11-08" @default.
- W4308178002 creator A5001327917 @default.
- W4308178002 creator A5009347504 @default.
- W4308178002 creator A5027943437 @default.
- W4308178002 creator A5032396875 @default.
- W4308178002 creator A5049351556 @default.
- W4308178002 creator A5064540072 @default.
- W4308178002 creator A5074942308 @default.
- W4308178002 creator A5082496274 @default.
- W4308178002 creator A5088518232 @default.
- W4308178002 creator A5089390131 @default.
- W4308178002 date "2022-11-04" @default.
- W4308178002 modified "2023-10-17" @default.
- W4308178002 title "Stem Cell‐Niche Engineering via Multifunctional Hydrogel Potentiates Stem Cell Therapies for Inflammatory Bone Loss" @default.
- W4308178002 cites W1505671001 @default.
- W4308178002 cites W1965953554 @default.
- W4308178002 cites W1969604041 @default.
- W4308178002 cites W1985738247 @default.
- W4308178002 cites W1993961357 @default.
- W4308178002 cites W1997694334 @default.
- W4308178002 cites W2011787884 @default.
- W4308178002 cites W2022915249 @default.
- W4308178002 cites W2025921479 @default.
- W4308178002 cites W2032952017 @default.
- W4308178002 cites W2036122797 @default.
- W4308178002 cites W2036557984 @default.
- W4308178002 cites W2039057018 @default.
- W4308178002 cites W2039396493 @default.
- W4308178002 cites W2041369768 @default.
- W4308178002 cites W2043005091 @default.
- W4308178002 cites W2054834390 @default.
- W4308178002 cites W2055424631 @default.
- W4308178002 cites W2067897176 @default.
- W4308178002 cites W2069527111 @default.
- W4308178002 cites W2075734368 @default.
- W4308178002 cites W2079145649 @default.
- W4308178002 cites W2083069870 @default.
- W4308178002 cites W2106315777 @default.
- W4308178002 cites W2129431680 @default.
- W4308178002 cites W2134208433 @default.
- W4308178002 cites W2171133944 @default.
- W4308178002 cites W2197714088 @default.
- W4308178002 cites W2257881775 @default.
- W4308178002 cites W2268621348 @default.
- W4308178002 cites W2288941079 @default.
- W4308178002 cites W2290540040 @default.
- W4308178002 cites W2315234938 @default.
- W4308178002 cites W2372967567 @default.
- W4308178002 cites W2508710172 @default.
- W4308178002 cites W2534260268 @default.
- W4308178002 cites W2732446419 @default.
- W4308178002 cites W2750180661 @default.
- W4308178002 cites W2752206357 @default.
- W4308178002 cites W2754152063 @default.
- W4308178002 cites W2755238052 @default.
- W4308178002 cites W2771263162 @default.
- W4308178002 cites W2772744597 @default.
- W4308178002 cites W2772755903 @default.
- W4308178002 cites W2800099600 @default.
- W4308178002 cites W2885799223 @default.
- W4308178002 cites W2891083159 @default.
- W4308178002 cites W2898700653 @default.
- W4308178002 cites W2918015724 @default.
- W4308178002 cites W2925256636 @default.
- W4308178002 cites W2936423264 @default.
- W4308178002 cites W2989852131 @default.
- W4308178002 cites W3008439310 @default.
- W4308178002 cites W3014468186 @default.
- W4308178002 cites W3023738419 @default.
- W4308178002 cites W3033593390 @default.
- W4308178002 cites W3038385682 @default.
- W4308178002 cites W3081351409 @default.
- W4308178002 cites W3087347736 @default.
- W4308178002 cites W3095409923 @default.
- W4308178002 cites W3107593984 @default.
- W4308178002 cites W3118127861 @default.
- W4308178002 cites W3127698120 @default.
- W4308178002 cites W3137979617 @default.
- W4308178002 cites W3152018805 @default.
- W4308178002 cites W3183554099 @default.
- W4308178002 cites W3185053343 @default.
- W4308178002 cites W3185221552 @default.
- W4308178002 cites W3185795542 @default.
- W4308178002 cites W3191830829 @default.
- W4308178002 cites W3193150046 @default.
- W4308178002 cites W3198340505 @default.
- W4308178002 cites W3205857213 @default.
- W4308178002 cites W4200371304 @default.
- W4308178002 cites W4213038867 @default.
- W4308178002 cites W4229378155 @default.
- W4308178002 cites W4283029637 @default.
- W4308178002 doi "https://doi.org/10.1002/adfm.202209466" @default.
- W4308178002 hasPublicationYear "2022" @default.
- W4308178002 type Work @default.
- W4308178002 citedByCount "10" @default.
- W4308178002 countsByYear W43081780022022 @default.
- W4308178002 countsByYear W43081780022023 @default.