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- W4308180601 abstract "Accumulation and propagation of pathological α-synuclein (α-Syn) are the major contributing factors to the pathogenesis of Parkinson's disease (PD). Therapy to halt the spreading of α-Syn pathology needs to be established.After phage display and affinity maturation, human-derived anti-α-Syn autoantibodies were selected and applied to biochemical, cellular and animal models of PD.The novel naturally occurring anti-α-Syn autoantibodies (α-Syn-nAbs), P21 and P22, selectively bind α-Syn preformed fibrils (PFFs), recognise Lewy bodies (LBs) and Lewy neurites (LNs) in human PD brains, block α-Syn fibrillization and inhibit the seeding of α-Syn PFFs. Moreover, systematic administration of P21 and P22 attenuates α-Syn pathology, degeneration of the nigrostriatal pathway and motor deficits in mice injected with α-Syn PFFs.P21 and P22 attenuate α-synuclein pathology and are promising candidates for PD treatment." @default.
- W4308180601 created "2022-11-08" @default.
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- W4308180601 date "2022-11-16" @default.
- W4308180601 modified "2023-09-28" @default.
- W4308180601 title "Novel naturally occurring autoantibodies attenuate α‐synuclein pathology in a mouse model of Parkinson's disease" @default.
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- W4308180601 doi "https://doi.org/10.1111/nan.12860" @default.
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