FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308180695> ?p ?o ?g. }

• W4308180695 endingPage "2468" @default.
• W4308180695 startingPage "2459" @default.
• W4308180695 abstract "Objective: Hydroxychloroquine, a drug used for malaria and autoimmune diseases reportedly has beneficial effects against preeclampsia in pregnant women with lupus. However, its mechanism against preeclampsia remains unclear. We investigated the effect of hydroxychloroquine on an Nω-nitro-l-arginine methyl ester-induced preeclampsia rat model. Methods: Pregnant Sprague–Dawley rats were divided into four groups based on treatment (administered on gestational days 7–18): control, Nω-nitro-l-arginine methyl ester, hydroxychloroquine, and Nω-nitro-l-arginine methyl ester plus hydroxychloroquine. All animals were sacrificed on gestational day 19. We assayed tube formation and determined reactive oxygen species levels using human umbilical vein endothelial cells. Results: Results showed that hydroxychloroquine significantly lowered mean systolic blood pressure (P< 0.05) in Nω-nitro-l-arginine methyl ester-treated rats. Hydroxychloroquine did not affect their fetal and placental weights. Hydroxychloroquine mitigated Nω-nitro-l-arginine methyl ester-associated changes in proteinuria (P< 0.05). It normalized plasma soluble fms-like kinase-1 (P< 0.05) and endothelin-1 (P< 0.01) levels. In the tube formation assay, hydroxychloroquine increased the total meshes area (P< 0.05) and mitigated Nω-nitro-l-arginine methyl ester–induced reactive oxygen species formation (P< 0.05) in human umbilical vein endothelial cells. Conclusion: We conclude that hydroxychloroquine alleviated hypertension, proteinuria, and normalized soluble fms-like kinase-1 and endothelin-1 levels in our preeclampsia model and that these changes may involve the restoration of endothelial dysfunction; thus, hydroxychloroquine could potentially be used for preventing preeclampsia, even in the absence of lupus." @default.
• W4308180695 created "2022-11-08" @default.
• W4308180695 creator A5010885552 @default.
• W4308180695 creator A5017583833 @default.
• W4308180695 creator A5037156309 @default.
• W4308180695 creator A5039449032 @default.
• W4308180695 creator A5041602936 @default.
• W4308180695 creator A5042327417 @default.
• W4308180695 creator A5069933095 @default.
• W4308180695 creator A5075444776 @default.
• W4308180695 creator A5081292251 @default.
• W4308180695 creator A5084612463 @default.
• W4308180695 date "2022-08-26" @default.
• W4308180695 modified "2023-09-23" @default.
• W4308180695 title "Hydroxychloroquine reduces hypertension and soluble fms-like kinase-1 in a N ω-nitro-l-arginine methyl ester-induced preeclampsia rat model" @default.
• W4308180695 cites W1499461126 @default.
• W4308180695 cites W1820454135 @default.
• W4308180695 cites W1966792319 @default.
• W4308180695 cites W1997043423 @default.
• W4308180695 cites W2005062268 @default.
• W4308180695 cites W2019151860 @default.
• W4308180695 cites W2019991810 @default.
• W4308180695 cites W2020337923 @default.
• W4308180695 cites W2033000623 @default.
• W4308180695 cites W2035553319 @default.
• W4308180695 cites W2042011929 @default.
• W4308180695 cites W2045172661 @default.
• W4308180695 cites W2056493149 @default.
• W4308180695 cites W2088213792 @default.
• W4308180695 cites W2090798565 @default.
• W4308180695 cites W2104743428 @default.
• W4308180695 cites W2105318687 @default.
• W4308180695 cites W2105798455 @default.
• W4308180695 cites W2105865448 @default.
• W4308180695 cites W2143180984 @default.
• W4308180695 cites W2144889596 @default.
• W4308180695 cites W2152401910 @default.
• W4308180695 cites W2156835401 @default.
• W4308180695 cites W2161817495 @default.
• W4308180695 cites W2165753570 @default.
• W4308180695 cites W2167876892 @default.
• W4308180695 cites W2169154968 @default.
• W4308180695 cites W2207231158 @default.
• W4308180695 cites W2229705898 @default.
• W4308180695 cites W2233474513 @default.
• W4308180695 cites W2239180132 @default.
• W4308180695 cites W2319070923 @default.
• W4308180695 cites W2484488830 @default.
• W4308180695 cites W2519562388 @default.
• W4308180695 cites W2520571625 @default.
• W4308180695 cites W2549074801 @default.
• W4308180695 cites W2559336198 @default.
• W4308180695 cites W2560132701 @default.
• W4308180695 cites W2626026527 @default.
• W4308180695 cites W2799569683 @default.
• W4308180695 cites W2800162251 @default.
• W4308180695 cites W2889999733 @default.
• W4308180695 cites W2894011049 @default.
• W4308180695 cites W2925197848 @default.
• W4308180695 cites W2938469046 @default.
• W4308180695 cites W2946127583 @default.
• W4308180695 cites W2947476482 @default.
• W4308180695 cites W2970423612 @default.
• W4308180695 cites W2971869379 @default.
• W4308180695 cites W3004709581 @default.
• W4308180695 cites W3006528698 @default.
• W4308180695 cites W3014094191 @default.
• W4308180695 cites W3042646635 @default.
• W4308180695 cites W3044591236 @default.
• W4308180695 cites W3047961043 @default.
• W4308180695 cites W3131970654 @default.
• W4308180695 cites W3187318779 @default.
• W4308180695 cites W4241966887 @default.
• W4308180695 doi "https://doi.org/10.1097/hjh.0000000000003279" @default.
• W4308180695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36321404" @default.
• W4308180695 hasPublicationYear "2022" @default.
• W4308180695 type Work @default.
• W4308180695 citedByCount "0" @default.
• W4308180695 crossrefType "journal-article" @default.
• W4308180695 hasAuthorship W4308180695A5010885552 @default.
• W4308180695 hasAuthorship W4308180695A5017583833 @default.
• W4308180695 hasAuthorship W4308180695A5037156309 @default.
• W4308180695 hasAuthorship W4308180695A5039449032 @default.
• W4308180695 hasAuthorship W4308180695A5041602936 @default.
• W4308180695 hasAuthorship W4308180695A5042327417 @default.
• W4308180695 hasAuthorship W4308180695A5069933095 @default.
• W4308180695 hasAuthorship W4308180695A5075444776 @default.
• W4308180695 hasAuthorship W4308180695A5081292251 @default.
• W4308180695 hasAuthorship W4308180695A5084612463 @default.
• W4308180695 hasConcept C126322002 @default.
• W4308180695 hasConcept C134018914 @default.
• W4308180695 hasConcept C185592680 @default.
• W4308180695 hasConcept C202751555 @default.
• W4308180695 hasConcept C2777218350 @default.
• W4308180695 hasConcept C2777411675 @default.
• W4308180695 hasConcept C2779123688 @default.
• W4308180695 hasConcept C2779134260 @default.
• W4308180695 hasConcept C2779234561 @default.

• next