FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308180870> ?p ?o ?g. }

• W4308180870 endingPage "871" @default.
• W4308180870 startingPage "857" @default.
• W4308180870 abstract "Mitochondrial DNA (mtDNA) somatic mutations play important roles in the initiation and progression of cancer. Although next‐generation sequencing (NGS) of paired tumor and control samples has become a common practice to identify tumor‐specific mtDNA mutations, the unique nature of mtDNA and NGS‐associated sequencing bias could cause false‐positive/‐negative somatic mutation calling. Additionally, there are clinical scenarios where matched control tissues are unavailable for comparison. Therefore, a novel approach for accurately identifying somatic mtDNA variants is greatly needed, particularly in the absence of matched controls. In this study, the ground truth mtDNA variants orthogonally validated by triple‐paired tumor, adjacent nontumor, and blood samples were used to develop mitoSomatic, a random forest‐based machine learning tool. We demonstrated that mitoSomatic achieved area under the curve (AUC) values over 0.99 for identifying somatic mtDNA variants without paired control in three tumor types. In addition, mitoSomatic was also applicable in nontumor tissues such as adjacent nontumor and blood samples, suggesting the flexibility of mitoSomatic's classification capability. Furthermore, analysis of triple‐paired samples identified a small group of variants with uncertain somatic/germline origin, whereas application of mitoSomatic significantly facilitated the prediction of their possible source. Finally, a control‐free evaluation of the public pan‐cancer NGS dataset with mitoSomatic revealed a substantial number of variants that were probably misclassified by conventional tumor‐control comparison, further emphasizing the usefulness of mitoSomatic in application. Taken together, our study demonstrates that mitoSomatic is valuable for accurately identifying somatic mtDNA variants in mtDNA NGS data without paired controls, applicable for both tumor and nontumor tissues." @default.
• W4308180870 created "2022-11-08" @default.
• W4308180870 creator A5009138463 @default.
• W4308180870 creator A5023363049 @default.
• W4308180870 creator A5023923286 @default.
• W4308180870 creator A5027490097 @default.
• W4308180870 creator A5044360917 @default.
• W4308180870 creator A5047751161 @default.
• W4308180870 creator A5056987384 @default.
• W4308180870 creator A5073403869 @default.
• W4308180870 creator A5074907143 @default.
• W4308180870 creator A5087025928 @default.
• W4308180870 date "2022-12-15" @default.
• W4308180870 modified "2023-10-12" @default.
• W4308180870 title "<scp>mitoSomatic</scp>: a tool for accurate identification of mitochondrial <scp>DNA</scp> somatic mutations without paired controls" @default.
• W4308180870 cites W1520910338 @default.
• W4308180870 cites W1772428904 @default.
• W4308180870 cites W1959574505 @default.
• W4308180870 cites W1968408636 @default.
• W4308180870 cites W1984068087 @default.
• W4308180870 cites W2011645981 @default.
• W4308180870 cites W2070143299 @default.
• W4308180870 cites W2080601544 @default.
• W4308180870 cites W2107356675 @default.
• W4308180870 cites W2108234281 @default.
• W4308180870 cites W2111326065 @default.
• W4308180870 cites W2112005039 @default.
• W4308180870 cites W2119180969 @default.
• W4308180870 cites W2122732537 @default.
• W4308180870 cites W2135893370 @default.
• W4308180870 cites W2156603613 @default.
• W4308180870 cites W2164277750 @default.
• W4308180870 cites W2191690548 @default.
• W4308180870 cites W2202187342 @default.
• W4308180870 cites W2480725775 @default.
• W4308180870 cites W2555298751 @default.
• W4308180870 cites W2611907049 @default.
• W4308180870 cites W2674532415 @default.
• W4308180870 cites W2793994670 @default.
• W4308180870 cites W2897815364 @default.
• W4308180870 cites W2923343165 @default.
• W4308180870 cites W3004462687 @default.
• W4308180870 cites W3088380002 @default.
• W4308180870 cites W3090978739 @default.
• W4308180870 cites W3099717514 @default.
• W4308180870 cites W3104363880 @default.
• W4308180870 cites W3116307610 @default.
• W4308180870 cites W3140448916 @default.
• W4308180870 cites W3164138302 @default.
• W4308180870 cites W3200707343 @default.
• W4308180870 cites W4206045857 @default.
• W4308180870 doi "https://doi.org/10.1002/1878-0261.13335" @default.
• W4308180870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36330809" @default.
• W4308180870 hasPublicationYear "2022" @default.
• W4308180870 type Work @default.
• W4308180870 citedByCount "0" @default.
• W4308180870 crossrefType "journal-article" @default.
• W4308180870 hasAuthorship W4308180870A5009138463 @default.
• W4308180870 hasAuthorship W4308180870A5023363049 @default.
• W4308180870 hasAuthorship W4308180870A5023923286 @default.
• W4308180870 hasAuthorship W4308180870A5027490097 @default.
• W4308180870 hasAuthorship W4308180870A5044360917 @default.
• W4308180870 hasAuthorship W4308180870A5047751161 @default.
• W4308180870 hasAuthorship W4308180870A5056987384 @default.
• W4308180870 hasAuthorship W4308180870A5073403869 @default.
• W4308180870 hasAuthorship W4308180870A5074907143 @default.
• W4308180870 hasAuthorship W4308180870A5087025928 @default.
• W4308180870 hasBestOaLocation W43081808701 @default.
• W4308180870 hasConcept C104317684 @default.
• W4308180870 hasConcept C109825262 @default.
• W4308180870 hasConcept C134305767 @default.
• W4308180870 hasConcept C13514818 @default.
• W4308180870 hasConcept C135763542 @default.
• W4308180870 hasConcept C153911025 @default.
• W4308180870 hasConcept C197754878 @default.
• W4308180870 hasConcept C19811304 @default.
• W4308180870 hasConcept C24586158 @default.
• W4308180870 hasConcept C501734568 @default.
• W4308180870 hasConcept C51679486 @default.
• W4308180870 hasConcept C54355233 @default.
• W4308180870 hasConcept C552990157 @default.
• W4308180870 hasConcept C70721500 @default.
• W4308180870 hasConcept C86803240 @default.
• W4308180870 hasConceptScore W4308180870C104317684 @default.
• W4308180870 hasConceptScore W4308180870C109825262 @default.
• W4308180870 hasConceptScore W4308180870C134305767 @default.
• W4308180870 hasConceptScore W4308180870C13514818 @default.
• W4308180870 hasConceptScore W4308180870C135763542 @default.
• W4308180870 hasConceptScore W4308180870C153911025 @default.
• W4308180870 hasConceptScore W4308180870C197754878 @default.
• W4308180870 hasConceptScore W4308180870C19811304 @default.
• W4308180870 hasConceptScore W4308180870C24586158 @default.
• W4308180870 hasConceptScore W4308180870C501734568 @default.
• W4308180870 hasConceptScore W4308180870C51679486 @default.
• W4308180870 hasConceptScore W4308180870C54355233 @default.
• W4308180870 hasConceptScore W4308180870C552990157 @default.
• W4308180870 hasConceptScore W4308180870C70721500 @default.
• W4308180870 hasConceptScore W4308180870C86803240 @default.

• next