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- W4308181804 abstract "Abstract The 14-3-3 gene plays important role in many biological processes, including cell survival, apoptosis, and signal transduction. However, function of the 14-3-3 homologous gene in Musca domestica remains unclear. Here, we identified and characterized the 14-3-3ζ of M. domestica. We found that Md14-3-3ζ gene was highly homologous with other close insects. The qRT–PCR analysis revealed that the Md14-3-3ζ was highly expressed in adults, and was expressed predominantly in hemocytes and fat body. Meanwhile, the expression of Md14-3-3ζ was up-regulated after injecting Escherichia coli and Staphylococcus aureus. Moreover, the recombinant protein rMd14-3-3ζ strongly inhibits the growth of E. coli and S. aureus. Notably, the rMd14-3-3ζ inhibits E. coli and S. aureus by permeating the cell membrane. Taken together, our findings suggested that Md14-3-3ζ is involved in the immune response against bacteria through damaging the cell membrane." @default.
- W4308181804 created "2022-11-08" @default.
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- W4308181804 date "2022-09-01" @default.
- W4308181804 modified "2023-09-30" @default.
- W4308181804 title "Molecular Characterization of <i>14-3-3 Zeta</i> Gene in <i>Musca domestica</i> (Diptera: Muscidae) and Its Roles in Response to Bacterial Infection" @default.
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- W4308181804 doi "https://doi.org/10.1093/jisesa/ieac061" @default.
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