FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308182655> ?p ?o ?g. }

• W4308182655 abstract "Background: Septal strain patterns measured by echocardiography reflect the severity of left bundle branch block (LBBB)-induced left ventricular (LV) dysfunction. We investigated whether these LBBB strain stages predicted the response to cardiac resynchronization therapy in an observational study and developed a sheep model of LBBB-induced cardiomyopathy. Methods: The clinical study enrolled cardiac resynchronization therapy patients who underwent echocardiographic examination with speckle-tracking strain analysis before cardiac resynchronization therapy implant. In an experimental sheep model with pacing-induced dyssynchrony, LV remodeling and strain were assessed at baseline, at 8 and 16 weeks. Septal strain curves were classified into 5 patterns (LBBB-0 to LBBB-4). Results: The clinical study involved 250 patients (age 65 [58; 72] years; 79% men; 89% LBBB) with a median LV ejection fraction of 25 [21; 30]%. Across the stages, cardiac resynchronization therapy resulted in a gradual volumetric response, ranging from no response in LBBB-0 patients (ΔLV end-systolic volume 0 [−12; 15]%) to super-response in LBBB-4 patients (ΔLV end-systolic volume −44 [−64; −18]%) ( P< 0.001). LBBB-0 patients had a less favorable long-term outcome compared with those in stage LBBB≥1 (log-rank P =0.003). In 13 sheep, acute right ventricular pacing resulted in LBBB-1 (23%) and LBBB-2 (77%) patterns. Over the course of 8−16 weeks, continued pacing resulted in progressive LBBB-induced dysfunction, coincident with a transition to advanced strain patterns (92% LBBB-2 and 8% LBBB-3 at week 8; 75% LBBB-3 and 25% LBBB-4 at week 16) ( P =0.023). Conclusions: The strain-based LBBB classification reflects a pathophysiological continuum of LBBB-induced remodeling over time and is associated with the extent of reverse remodeling in observational cardiac resynchronization therapy-eligible patients." @default.
• W4308182655 created "2022-11-09" @default.
• W4308182655 creator A5000577598 @default.
• W4308182655 creator A5016878366 @default.
• W4308182655 creator A5019511082 @default.
• W4308182655 creator A5025912706 @default.
• W4308182655 creator A5032427784 @default.
• W4308182655 creator A5045666124 @default.
• W4308182655 creator A5048467349 @default.
• W4308182655 creator A5055704659 @default.
• W4308182655 creator A5058372949 @default.
• W4308182655 creator A5059691866 @default.
• W4308182655 creator A5086463058 @default.
• W4308182655 creator A5089572231 @default.
• W4308182655 date "2022-11-01" @default.
• W4308182655 modified "2023-10-18" @default.
• W4308182655 title "Clinical and Experimental Evidence for a Strain-Based Classification of Left Bundle Branch Block-Induced Cardiac Remodeling" @default.
• W4308182655 cites W2022919976 @default.
• W4308182655 cites W2111834353 @default.
• W4308182655 cites W2113572732 @default.
• W4308182655 cites W2114102492 @default.
• W4308182655 cites W2134247180 @default.
• W4308182655 cites W2148719028 @default.
• W4308182655 cites W2152870162 @default.
• W4308182655 cites W2162651058 @default.
• W4308182655 cites W2174325278 @default.
• W4308182655 cites W2296778778 @default.
• W4308182655 cites W2318224899 @default.
• W4308182655 cites W2567389850 @default.
• W4308182655 cites W2778970071 @default.
• W4308182655 cites W2785820950 @default.
• W4308182655 cites W2891114404 @default.
• W4308182655 cites W2898194964 @default.
• W4308182655 cites W2904843406 @default.
• W4308182655 cites W2914985366 @default.
• W4308182655 cites W2936426194 @default.
• W4308182655 cites W2941269128 @default.
• W4308182655 cites W2942971807 @default.
• W4308182655 cites W2972576123 @default.
• W4308182655 cites W2999745482 @default.
• W4308182655 cites W3006358304 @default.
• W4308182655 cites W3086791728 @default.
• W4308182655 cites W3097044031 @default.
• W4308182655 cites W3128081343 @default.
• W4308182655 cites W3132231891 @default.
• W4308182655 cites W3153485871 @default.
• W4308182655 doi "https://doi.org/10.1161/circimaging.122.014296" @default.
• W4308182655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36330792" @default.
• W4308182655 hasPublicationYear "2022" @default.
• W4308182655 type Work @default.
• W4308182655 citedByCount "1" @default.
• W4308182655 countsByYear W43081826552022 @default.
• W4308182655 crossrefType "journal-article" @default.
• W4308182655 hasAuthorship W4308182655A5000577598 @default.
• W4308182655 hasAuthorship W4308182655A5016878366 @default.
• W4308182655 hasAuthorship W4308182655A5019511082 @default.
• W4308182655 hasAuthorship W4308182655A5025912706 @default.
• W4308182655 hasAuthorship W4308182655A5032427784 @default.
• W4308182655 hasAuthorship W4308182655A5045666124 @default.
• W4308182655 hasAuthorship W4308182655A5048467349 @default.
• W4308182655 hasAuthorship W4308182655A5055704659 @default.
• W4308182655 hasAuthorship W4308182655A5058372949 @default.
• W4308182655 hasAuthorship W4308182655A5059691866 @default.
• W4308182655 hasAuthorship W4308182655A5086463058 @default.
• W4308182655 hasAuthorship W4308182655A5089572231 @default.
• W4308182655 hasBestOaLocation W43081826551 @default.
• W4308182655 hasConcept C126322002 @default.
• W4308182655 hasConcept C164705383 @default.
• W4308182655 hasConcept C2776034619 @default.
• W4308182655 hasConcept C2777233412 @default.
• W4308182655 hasConcept C2777473070 @default.
• W4308182655 hasConcept C2778198053 @default.
• W4308182655 hasConcept C2778296771 @default.
• W4308182655 hasConcept C2778797674 @default.
• W4308182655 hasConcept C2780040984 @default.
• W4308182655 hasConcept C71924100 @default.
• W4308182655 hasConcept C78085059 @default.
• W4308182655 hasConceptScore W4308182655C126322002 @default.
• W4308182655 hasConceptScore W4308182655C164705383 @default.
• W4308182655 hasConceptScore W4308182655C2776034619 @default.
• W4308182655 hasConceptScore W4308182655C2777233412 @default.
• W4308182655 hasConceptScore W4308182655C2777473070 @default.
• W4308182655 hasConceptScore W4308182655C2778198053 @default.
• W4308182655 hasConceptScore W4308182655C2778296771 @default.
• W4308182655 hasConceptScore W4308182655C2778797674 @default.
• W4308182655 hasConceptScore W4308182655C2780040984 @default.
• W4308182655 hasConceptScore W4308182655C71924100 @default.
• W4308182655 hasConceptScore W4308182655C78085059 @default.
• W4308182655 hasIssue "11" @default.
• W4308182655 hasLocation W43081826551 @default.
• W4308182655 hasLocation W43081826552 @default.
• W4308182655 hasOpenAccess W4308182655 @default.
• W4308182655 hasPrimaryLocation W43081826551 @default.
• W4308182655 hasRelatedWork W1969917551 @default.
• W4308182655 hasRelatedWork W2004432304 @default.
• W4308182655 hasRelatedWork W2257679457 @default.
• W4308182655 hasRelatedWork W2587323853 @default.
• W4308182655 hasRelatedWork W2908513992 @default.
• W4308182655 hasRelatedWork W2972563054 @default.
• W4308182655 hasRelatedWork W2999204693 @default.

• next