Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308183663> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4308183663 endingPage "710" @default.
- W4308183663 startingPage "703" @default.
- W4308183663 abstract "Capillary morphogenesis gene 2 (CMG2) is involved in prostate and breast cancer progression. This study aimed to investigate sex hormone receptor-mediated regulation of CMG2 in breast and prostate cancer, and its implication in disease progression.Expression of CMG2, oestrogen receptor (ER) and androgen receptor (AR) was determined in breast and prostate cancer cell lines, respectively, using real-time quantitative PCR (QPCR) and western blot. Association between CMG2 and sex hormone receptors was analysed in a number of transcriptome datasets. Immunochemical staining was performed in tissue microarrays of breast cancer (BR1505D) and prostate cancer (PR8011A). CMG2 expression was determined in 17β-oestradiol treated breast cancer cells and AR over-expressing prostate cancer cells.CMG2 was found to be inversely correlated with sex hormone receptors in breast and prostate cancer. Lower expression of CMG2 was associated with a poor prognosis in ER (+) breast cancer but not ER (-) tumours. Both ER (+) breast cancer cell lines and AR (+) prostate cancer cell lines presented lower expression of CMG2, which was increased following sex hormone deprivation. Exposure to 17-β-oestradiol and AR over-expression repressed CMG2 expression in breast cancer and prostate cancer cell lines, respectively.CMG2 is inversely correlated with ER and AR status in breast and prostate cancer, respectively. ER and AR mediate repression of CMG2 expression in corresponding cancerous cells." @default.
- W4308183663 created "2022-11-09" @default.
- W4308183663 creator A5017984665 @default.
- W4308183663 creator A5036206376 @default.
- W4308183663 creator A5046287902 @default.
- W4308183663 creator A5058047301 @default.
- W4308183663 creator A5060127545 @default.
- W4308183663 creator A5062342669 @default.
- W4308183663 creator A5066459661 @default.
- W4308183663 creator A5087459949 @default.
- W4308183663 date "2022-01-01" @default.
- W4308183663 modified "2023-09-26" @default.
- W4308183663 title "Sex Hormone-regulated<i>CMG2</i>Is Involved in Breast and Prostate Cancer Progression" @default.
- W4308183663 cites W1967495064 @default.
- W4308183663 cites W1980861196 @default.
- W4308183663 cites W1983866690 @default.
- W4308183663 cites W2008549629 @default.
- W4308183663 cites W2056608649 @default.
- W4308183663 cites W2064293531 @default.
- W4308183663 cites W2083670089 @default.
- W4308183663 cites W2088190106 @default.
- W4308183663 cites W2107277218 @default.
- W4308183663 cites W2109541504 @default.
- W4308183663 cites W2113225995 @default.
- W4308183663 cites W2181283187 @default.
- W4308183663 cites W2192080449 @default.
- W4308183663 cites W2944727022 @default.
- W4308183663 cites W2964293297 @default.
- W4308183663 cites W3169645397 @default.
- W4308183663 cites W3185354749 @default.
- W4308183663 cites W960284382 @default.
- W4308183663 doi "https://doi.org/10.21873/cgp.20353" @default.
- W4308183663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36316045" @default.
- W4308183663 hasPublicationYear "2022" @default.
- W4308183663 type Work @default.
- W4308183663 citedByCount "1" @default.
- W4308183663 countsByYear W43081836632023 @default.
- W4308183663 crossrefType "journal-article" @default.
- W4308183663 hasAuthorship W4308183663A5017984665 @default.
- W4308183663 hasAuthorship W4308183663A5036206376 @default.
- W4308183663 hasAuthorship W4308183663A5046287902 @default.
- W4308183663 hasAuthorship W4308183663A5058047301 @default.
- W4308183663 hasAuthorship W4308183663A5060127545 @default.
- W4308183663 hasAuthorship W4308183663A5062342669 @default.
- W4308183663 hasAuthorship W4308183663A5066459661 @default.
- W4308183663 hasAuthorship W4308183663A5087459949 @default.
- W4308183663 hasBestOaLocation W43081836631 @default.
- W4308183663 hasConcept C121608353 @default.
- W4308183663 hasConcept C126322002 @default.
- W4308183663 hasConcept C134018914 @default.
- W4308183663 hasConcept C2776235491 @default.
- W4308183663 hasConcept C2780192828 @default.
- W4308183663 hasConcept C2781406297 @default.
- W4308183663 hasConcept C502942594 @default.
- W4308183663 hasConcept C530470458 @default.
- W4308183663 hasConcept C61367390 @default.
- W4308183663 hasConcept C71924100 @default.
- W4308183663 hasConcept C86803240 @default.
- W4308183663 hasConcept C87874733 @default.
- W4308183663 hasConceptScore W4308183663C121608353 @default.
- W4308183663 hasConceptScore W4308183663C126322002 @default.
- W4308183663 hasConceptScore W4308183663C134018914 @default.
- W4308183663 hasConceptScore W4308183663C2776235491 @default.
- W4308183663 hasConceptScore W4308183663C2780192828 @default.
- W4308183663 hasConceptScore W4308183663C2781406297 @default.
- W4308183663 hasConceptScore W4308183663C502942594 @default.
- W4308183663 hasConceptScore W4308183663C530470458 @default.
- W4308183663 hasConceptScore W4308183663C61367390 @default.
- W4308183663 hasConceptScore W4308183663C71924100 @default.
- W4308183663 hasConceptScore W4308183663C86803240 @default.
- W4308183663 hasConceptScore W4308183663C87874733 @default.
- W4308183663 hasIssue "6" @default.
- W4308183663 hasLocation W43081836631 @default.
- W4308183663 hasLocation W43081836632 @default.
- W4308183663 hasLocation W43081836633 @default.
- W4308183663 hasLocation W43081836634 @default.
- W4308183663 hasLocation W43081836635 @default.
- W4308183663 hasOpenAccess W4308183663 @default.
- W4308183663 hasPrimaryLocation W43081836631 @default.
- W4308183663 hasRelatedWork W1497253641 @default.
- W4308183663 hasRelatedWork W2017040238 @default.
- W4308183663 hasRelatedWork W2021846196 @default.
- W4308183663 hasRelatedWork W2082569851 @default.
- W4308183663 hasRelatedWork W2094328082 @default.
- W4308183663 hasRelatedWork W2131098924 @default.
- W4308183663 hasRelatedWork W2170823000 @default.
- W4308183663 hasRelatedWork W2354678759 @default.
- W4308183663 hasRelatedWork W4282843086 @default.
- W4308183663 hasRelatedWork W4383737431 @default.
- W4308183663 hasVolume "19" @default.
- W4308183663 isParatext "false" @default.
- W4308183663 isRetracted "false" @default.
- W4308183663 workType "article" @default.