Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308183711> ?p ?o ?g. }
- W4308183711 endingPage "498" @default.
- W4308183711 startingPage "487" @default.
- W4308183711 abstract "The introduction of immune checkpoint inhibitors has transformed the treatment landscape of metastatic non-small cell lung cancer. However, challenges remain to increase the fraction of patients achieving durable clinical responses to these drugs and to help monitor the treatment effect. In this phase II trial, we investigated the toxicity, systemic responses and circulating tumour DNA responses in patients (n = 21) with advanced non-small-cell lung cancer treated with atezolizumab and stereotactic body radiotherapy in the second or later line. We found the combined treatment to be safe with grade 3 toxicity reported in three patients. As the best overall response, four patients had a partial response, eight had stable disease and five had progressive disease. Median overall survival time was still not reached after a median follow-up of 26.5 months and 10/15 patients with programmed death-ligand 1 negative tumours were alive >18 months after the start of the study treatment. ctDNA was detectable at baseline in 11 patients. A rapid decline in ctDNA to <30% of baseline levels was seen in three patients, two of which were radiographic responders and one was considered clinically benefiting from therapy for almost 1 year." @default.
- W4308183711 created "2022-11-09" @default.
- W4308183711 creator A5003090957 @default.
- W4308183711 creator A5015494717 @default.
- W4308183711 creator A5016502312 @default.
- W4308183711 creator A5016888096 @default.
- W4308183711 creator A5036822436 @default.
- W4308183711 creator A5036905259 @default.
- W4308183711 creator A5039780932 @default.
- W4308183711 creator A5041139487 @default.
- W4308183711 creator A5048974245 @default.
- W4308183711 creator A5055776119 @default.
- W4308183711 creator A5065771929 @default.
- W4308183711 creator A5084228112 @default.
- W4308183711 date "2022-11-22" @default.
- W4308183711 modified "2023-10-17" @default.
- W4308183711 title "Atezolizumab and stereotactic body radiotherapy in patients with advanced non‐small cell lung cancer: safety, clinical activity and <scp>ctDNA</scp> responses—the <scp>ComIT</scp>‐1 trial" @default.
- W4308183711 cites W2019607817 @default.
- W4308183711 cites W2080531964 @default.
- W4308183711 cites W2090883361 @default.
- W4308183711 cites W2156353875 @default.
- W4308183711 cites W2198964395 @default.
- W4308183711 cites W2293531514 @default.
- W4308183711 cites W2498387096 @default.
- W4308183711 cites W2527129822 @default.
- W4308183711 cites W2567564314 @default.
- W4308183711 cites W2572174216 @default.
- W4308183711 cites W2591447948 @default.
- W4308183711 cites W2766399158 @default.
- W4308183711 cites W2781730792 @default.
- W4308183711 cites W2783576981 @default.
- W4308183711 cites W2787553571 @default.
- W4308183711 cites W2790568323 @default.
- W4308183711 cites W2883160489 @default.
- W4308183711 cites W2883787611 @default.
- W4308183711 cites W2886963239 @default.
- W4308183711 cites W2898037973 @default.
- W4308183711 cites W2899376285 @default.
- W4308183711 cites W2900705038 @default.
- W4308183711 cites W2905051664 @default.
- W4308183711 cites W2911249025 @default.
- W4308183711 cites W2915998799 @default.
- W4308183711 cites W2942836156 @default.
- W4308183711 cites W2945864719 @default.
- W4308183711 cites W2946166987 @default.
- W4308183711 cites W2956407134 @default.
- W4308183711 cites W2972179964 @default.
- W4308183711 cites W2980101295 @default.
- W4308183711 cites W2986345377 @default.
- W4308183711 cites W3000702060 @default.
- W4308183711 cites W3014048998 @default.
- W4308183711 cites W3016686226 @default.
- W4308183711 cites W3024035973 @default.
- W4308183711 cites W3046009395 @default.
- W4308183711 cites W3092159910 @default.
- W4308183711 cites W3123073834 @default.
- W4308183711 cites W3139130539 @default.
- W4308183711 cites W3147142721 @default.
- W4308183711 cites W4292528167 @default.
- W4308183711 doi "https://doi.org/10.1002/1878-0261.13330" @default.
- W4308183711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36330681" @default.
- W4308183711 hasPublicationYear "2022" @default.
- W4308183711 type Work @default.
- W4308183711 citedByCount "2" @default.
- W4308183711 countsByYear W43081837112023 @default.
- W4308183711 crossrefType "journal-article" @default.
- W4308183711 hasAuthorship W4308183711A5003090957 @default.
- W4308183711 hasAuthorship W4308183711A5015494717 @default.
- W4308183711 hasAuthorship W4308183711A5016502312 @default.
- W4308183711 hasAuthorship W4308183711A5016888096 @default.
- W4308183711 hasAuthorship W4308183711A5036822436 @default.
- W4308183711 hasAuthorship W4308183711A5036905259 @default.
- W4308183711 hasAuthorship W4308183711A5039780932 @default.
- W4308183711 hasAuthorship W4308183711A5041139487 @default.
- W4308183711 hasAuthorship W4308183711A5048974245 @default.
- W4308183711 hasAuthorship W4308183711A5055776119 @default.
- W4308183711 hasAuthorship W4308183711A5065771929 @default.
- W4308183711 hasAuthorship W4308183711A5084228112 @default.
- W4308183711 hasBestOaLocation W43081837111 @default.
- W4308183711 hasConcept C121608353 @default.
- W4308183711 hasConcept C126322002 @default.
- W4308183711 hasConcept C126894567 @default.
- W4308183711 hasConcept C141071460 @default.
- W4308183711 hasConcept C143998085 @default.
- W4308183711 hasConcept C2775949291 @default.
- W4308183711 hasConcept C2776256026 @default.
- W4308183711 hasConcept C2776694085 @default.
- W4308183711 hasConcept C2777701055 @default.
- W4308183711 hasConcept C2778822529 @default.
- W4308183711 hasConcept C2780057760 @default.
- W4308183711 hasConcept C29730261 @default.
- W4308183711 hasConcept C509974204 @default.
- W4308183711 hasConcept C535046627 @default.
- W4308183711 hasConcept C71924100 @default.
- W4308183711 hasConcept C90924648 @default.
- W4308183711 hasConceptScore W4308183711C121608353 @default.
- W4308183711 hasConceptScore W4308183711C126322002 @default.
- W4308183711 hasConceptScore W4308183711C126894567 @default.