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- W4308183719 abstract "Abstract Oral bisphosphonates are a key intervention in the treatment of osteoporosis and in reducing the risk of fragility fractures. Their use is supported by over 3 decades of evidence; however, patient adherence to oral bisphosphonates remains poor in part due to complex dosing instructions and adverse events, including upper gastrointestinal symptoms. This problem has led to the development of novel oral bisphosphonate formulations. Buffered, effervescent alendronate is dissolved in water and so seeks to reduce upper gastro-intestinal adverse events, and gastro-resistant risedronate aims to reduce the complexity of dosing procedure (e.g. fasting prior to consumption) whilst still maintaining the efficacy of fracture risk reduction. Clinical trials and real-world data have been employed to demonstrate some benefits in terms of reduced upper gastro-intestinal adverse events, adherence, persistence and health economic outcomes. This report describes the result of an ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis) expert working group, which explores where oral bisphosphonates sit in current clinical practice guidelines, review their risk–benefit profile and the consequences of poor adherence before exploring novel oral bisphosphonate formulations and their potential clinical and health economic impact. Further research is required but there are signs that these novel, oral bisphosphonate formulations may lead to improved tolerance of oral bisphosphonates and thus, improved adherence and fracture outcomes." @default.
- W4308183719 created "2022-11-09" @default.
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- W4308183719 date "2022-11-04" @default.
- W4308183719 modified "2023-10-16" @default.
- W4308183719 title "Novel formulations of oral bisphosphonates in the treatment of osteoporosis" @default.
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- W4308183719 cites W1777836280 @default.
- W4308183719 cites W1908388217 @default.
- W4308183719 cites W1964983463 @default.
- W4308183719 cites W1968418396 @default.
- W4308183719 cites W1975738165 @default.
- W4308183719 cites W1980678053 @default.
- W4308183719 cites W1999766847 @default.
- W4308183719 cites W2009678900 @default.
- W4308183719 cites W2019292020 @default.
- W4308183719 cites W2024308635 @default.
- W4308183719 cites W2029205192 @default.
- W4308183719 cites W2029896549 @default.
- W4308183719 cites W2034238658 @default.
- W4308183719 cites W2049146115 @default.
- W4308183719 cites W2073962486 @default.
- W4308183719 cites W2081493419 @default.
- W4308183719 cites W2085850205 @default.
- W4308183719 cites W2094902038 @default.
- W4308183719 cites W2102123887 @default.
- W4308183719 cites W2108975652 @default.
- W4308183719 cites W2109950133 @default.
- W4308183719 cites W2115243808 @default.
- W4308183719 cites W2119562205 @default.
- W4308183719 cites W2124527463 @default.
- W4308183719 cites W2142372056 @default.
- W4308183719 cites W2147410460 @default.
- W4308183719 cites W2153009489 @default.
- W4308183719 cites W2158097928 @default.
- W4308183719 cites W2161837912 @default.
- W4308183719 cites W2164224167 @default.
- W4308183719 cites W2169251377 @default.
- W4308183719 cites W2336678594 @default.
- W4308183719 cites W2478331432 @default.
- W4308183719 cites W2499320807 @default.
- W4308183719 cites W2587229819 @default.
- W4308183719 cites W2754720807 @default.
- W4308183719 cites W2790318238 @default.
- W4308183719 cites W2811496043 @default.
- W4308183719 cites W2899004149 @default.
- W4308183719 cites W2906088582 @default.
- W4308183719 cites W2911959728 @default.
- W4308183719 cites W2969104249 @default.
- W4308183719 cites W2969635189 @default.
- W4308183719 cites W2971220230 @default.
- W4308183719 cites W2973632969 @default.
- W4308183719 cites W2980234248 @default.
- W4308183719 cites W3023298491 @default.
- W4308183719 cites W3041733543 @default.
- W4308183719 cites W3119246786 @default.
- W4308183719 cites W3119821562 @default.
- W4308183719 cites W3138346935 @default.
- W4308183719 cites W3140597801 @default.
- W4308183719 cites W3157933999 @default.
- W4308183719 cites W3186853119 @default.
- W4308183719 cites W3198454757 @default.
- W4308183719 cites W3204878543 @default.
- W4308183719 cites W4200389828 @default.
- W4308183719 cites W4221090414 @default.
- W4308183719 cites W4229334622 @default.
- W4308183719 cites W4236641936 @default.
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- W4308183719 doi "https://doi.org/10.1007/s40520-022-02272-z" @default.