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- W4308184512 abstract "Automated glycan assembly (AGA) on solid support has become invaluable in reconciling the biological importance of complex carbohydrates with the persistent challenges associated with reproducible synthesis. Whilst AGA platforms have transformed the construction of many natural sugars, validation in the construction of well-defined (site-selectively modified) glycomimetics is in its infancy. Motivated by the importance of fluorination in drug discovery, the biomedical prominence of 2-fluoro sugars and the remarkable selectivities observed in fluorine-directed glycosylation, fluorine-directed automated glycan assembly (FDAGA) is disclosed. This strategy leverages the fluorine atom for stereocontrolled glycosylation on solid support, thereby eliminating the reliance on O-based directing groups. The logical design of C2-fluorinated mannose building blocks, and their application in the fully (α-)stereocontrolled automated assembly of linear and branched fluorinated oligomannosides, is disclosed. This operationally simple strategy can be integrated into existing AGA and post-AGA protocols to augment the scope of programmed carbohydrate synthesis." @default.
- W4308184512 created "2022-11-09" @default.
- W4308184512 creator A5001316410 @default.
- W4308184512 creator A5050197366 @default.
- W4308184512 date "2022-12-12" @default.
- W4308184512 modified "2023-10-14" @default.
- W4308184512 title "Fluorine‐Directed Automated Mannoside Assembly" @default.
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- W4308184512 doi "https://doi.org/10.1002/anie.202213304" @default.
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