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- W4308186195 endingPage "204201882211321" @default.
- W4308186195 startingPage "204201882211321" @default.
- W4308186195 abstract "Nonalcoholic fatty liver disease (NAFLD) is becoming the most frequent chronic liver disease worldwide. Metabolic (dysfunction) associated fatty liver disease (MAFLD) is suggested to replace the nomenclature of NAFLD. For individuals with metabolic dysfunction, multiple NAFLD-related factors also contribute to the development and progression of MAFLD including genetics and epigenetics. The application of genome-wide association study (GWAS) and exome-wide association study (EWAS) uncovers single-nucleotide polymorphisms (SNPs) in MAFLD. In addition to the classic SNPs in PNPLA3, TM6SF2, and GCKR, some new SNPs have been found recently to contribute to the pathogenesis of liver steatosis. Epigenetic factors involving DNA methylation, histone modifications, non-coding RNAs regulations, and RNA methylation also play a critical role in MAFLD. DNA methylation is the most reported epigenetic modification. Developing a non-invasion biomarker to distinguish metabolic steatohepatitis (MASH) or liver fibrosis is ongoing. In this review, we summarized and discussed the latest progress in genetic and epigenetic factors of NAFLD/MAFLD, in order to provide potential clues for MAFLD treatment." @default.
- W4308186195 created "2022-11-09" @default.
- W4308186195 creator A5007273011 @default.
- W4308186195 creator A5025931317 @default.
- W4308186195 creator A5065049243 @default.
- W4308186195 date "2022-01-01" @default.
- W4308186195 modified "2023-10-14" @default.
- W4308186195 title "Update on genetics and epigenetics in metabolic associated fatty liver disease" @default.
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