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• W4308188863 endingPage "175909142211363" @default.
• W4308188863 startingPage "175909142211363" @default.
• W4308188863 abstract "Müller glial cells (MGCs), the main glial component of the retina, play an active role in retinal homeostasis during development and pathological processes. They strongly monitor retinal environment and, in response to retinal imbalance, activate neuroprotective mechanisms mainly characterized by the increase of glial fibrillary acidic protein (GFAP). Under these circumstances, if homeostasis is not reestablished, the retina can be severely injured and GFAP contributes to neuronal degeneration, as they occur in several proliferative retinopathies such as diabetic retinopathy, sickle cell retinopathy and retinopathy of prematurity. In addition, MGCs have an active participation in inflammatory responses releasing proinflammatory mediators and metalloproteinases to the extracellular space and vitreous cavity. MGCs are also involved in the retinal neovascularization and matrix extracellular remodeling during the proliferative stage of retinopathies. Interestingly, low-density lipoprotein receptor-related protein 1 (LRP1) and its ligand α 2 -macroglobulin (α 2 M) are highly expressed in MGCs and they have been established to participate in multiple cellular and molecular activities with relevance in retinopathies. However, the exact mechanism of regulation of retinal LRP1 in MGCs is still unclear. Thus, the active participation of MGCs and LRP1 in these diseases, strongly supports the potential interest of them for the design of novel therapeutic approaches. In this review, we discuss the role of LRP1 in the multiple MGCs activities involved in the development and progression of proliferative retinopathies, identifying opportunities in the field that beg further research in this topic area. Summary Statement MGCs and LRP1 are active players in injured retinas, participating in key features such as gliosis and neurotoxicity, neovascularization, inflammation, and glucose control homeostasis during the progression of ischemic diseases, such as proliferative retinopathies." @default.
• W4308188863 created "2022-11-09" @default.
• W4308188863 creator A5020234449 @default.
• W4308188863 creator A5063184441 @default.
• W4308188863 date "2022-01-01" @default.
• W4308188863 modified "2023-10-17" @default.
• W4308188863 title "Multitarget Activities of Müller Glial Cells and Low-Density Lipoprotein Receptor-Related Protein 1 in Proliferative Retinopathies" @default.
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• W4308188863 cites W1596751131 @default.
• W4308188863 cites W1597652886 @default.
• W4308188863 cites W1601380713 @default.
• W4308188863 cites W1965646247 @default.
• W4308188863 cites W1968238953 @default.
• W4308188863 cites W1968639426 @default.
• W4308188863 cites W1970929051 @default.
• W4308188863 cites W1994787638 @default.
• W4308188863 cites W1995230613 @default.
• W4308188863 cites W1996241541 @default.
• W4308188863 cites W1999726176 @default.
• W4308188863 cites W2002934996 @default.
• W4308188863 cites W2007325711 @default.
• W4308188863 cites W2010643385 @default.
• W4308188863 cites W2013226492 @default.
• W4308188863 cites W2021338387 @default.
• W4308188863 cites W2030324194 @default.
• W4308188863 cites W2049349550 @default.
• W4308188863 cites W2060141430 @default.
• W4308188863 cites W2063504478 @default.
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• W4308188863 cites W2079008207 @default.
• W4308188863 cites W2080846111 @default.
• W4308188863 cites W2083493656 @default.
• W4308188863 cites W2088059932 @default.
• W4308188863 cites W2090422278 @default.
• W4308188863 cites W2094867350 @default.
• W4308188863 cites W2143975632 @default.
• W4308188863 cites W2161344509 @default.
• W4308188863 cites W2162401979 @default.
• W4308188863 cites W2162993028 @default.
• W4308188863 cites W2179881030 @default.
• W4308188863 cites W2256722979 @default.
• W4308188863 cites W2263216802 @default.
• W4308188863 cites W2265978074 @default.
• W4308188863 cites W2396665399 @default.
• W4308188863 cites W2475909975 @default.
• W4308188863 cites W2496215719 @default.
• W4308188863 cites W2504637985 @default.
• W4308188863 cites W2521006596 @default.
• W4308188863 cites W2531112638 @default.
• W4308188863 cites W2560393860 @default.
• W4308188863 cites W2562141642 @default.
• W4308188863 cites W2573181011 @default.
• W4308188863 cites W2590026484 @default.
• W4308188863 cites W2605787410 @default.
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• W4308188863 cites W2808089237 @default.
• W4308188863 cites W2890063739 @default.
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• W4308188863 doi "https://doi.org/10.1177/17590914221136365" @default.
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