Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308189105> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4308189105 endingPage "8" @default.
- W4308189105 startingPage "1" @default.
- W4308189105 abstract "Chalcone is a molecule with known biological activities. Based on this, a series of chalcone derivatives bearing methyl, phenyl or furanyl substituents at different positions of A and B rings were synthesised, characterised, and evaluated regarding antiprotozoal activity. Molecules were synthesised via base catalyzed Claisen-Schmidt condensation and characterised by IR and NMR spectral data. Antiprotozoal activity against Phytomonas serpens, Leishmania amazonensis and Acanthamoeba polyphaga was performed. All compounds inhibited more than 50% of the growth of P. serpens while five had this effect on L. amazonensis and all of them no more than 35% of inhibition on A. polyphaga. Remarkably interesting antiprotozoal effects were recorded with compound 5, with IC50 of 1.59 µM for P. serpens and 11.49 µM for L. amazonensis. The addition of a naphthyl group to the B ring can be postulated to be the cause of the 10 times increase observed in its trypanocidal activity." @default.
- W4308189105 created "2022-11-09" @default.
- W4308189105 creator A5000368195 @default.
- W4308189105 creator A5001111852 @default.
- W4308189105 creator A5011255359 @default.
- W4308189105 creator A5013656021 @default.
- W4308189105 creator A5028660520 @default.
- W4308189105 creator A5031661625 @default.
- W4308189105 creator A5041291424 @default.
- W4308189105 creator A5049336843 @default.
- W4308189105 creator A5057747397 @default.
- W4308189105 creator A5058744252 @default.
- W4308189105 creator A5071996954 @default.
- W4308189105 date "2022-11-04" @default.
- W4308189105 modified "2023-09-27" @default.
- W4308189105 title "Synthesis of chalcone derivatives by Claisen-Schmidt condensation and <i>in vitro</i> analyses of their antiprotozoal activities" @default.
- W4308189105 cites W1487096070 @default.
- W4308189105 cites W1733625577 @default.
- W4308189105 cites W1970192788 @default.
- W4308189105 cites W2002879172 @default.
- W4308189105 cites W2055907760 @default.
- W4308189105 cites W2087242576 @default.
- W4308189105 cites W2092449318 @default.
- W4308189105 cites W2175122189 @default.
- W4308189105 cites W2180977097 @default.
- W4308189105 cites W2521378003 @default.
- W4308189105 cites W2559798560 @default.
- W4308189105 cites W2730840378 @default.
- W4308189105 cites W2741431452 @default.
- W4308189105 cites W2748053146 @default.
- W4308189105 cites W2752981360 @default.
- W4308189105 cites W289168472 @default.
- W4308189105 cites W2894669636 @default.
- W4308189105 cites W2912348619 @default.
- W4308189105 cites W2987034284 @default.
- W4308189105 cites W778585144 @default.
- W4308189105 doi "https://doi.org/10.1080/14786419.2022.2140337" @default.
- W4308189105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36331421" @default.
- W4308189105 hasPublicationYear "2022" @default.
- W4308189105 type Work @default.
- W4308189105 citedByCount "1" @default.
- W4308189105 countsByYear W43081891052023 @default.
- W4308189105 crossrefType "journal-article" @default.
- W4308189105 hasAuthorship W4308189105A5000368195 @default.
- W4308189105 hasAuthorship W4308189105A5001111852 @default.
- W4308189105 hasAuthorship W4308189105A5011255359 @default.
- W4308189105 hasAuthorship W4308189105A5013656021 @default.
- W4308189105 hasAuthorship W4308189105A5028660520 @default.
- W4308189105 hasAuthorship W4308189105A5031661625 @default.
- W4308189105 hasAuthorship W4308189105A5041291424 @default.
- W4308189105 hasAuthorship W4308189105A5049336843 @default.
- W4308189105 hasAuthorship W4308189105A5057747397 @default.
- W4308189105 hasAuthorship W4308189105A5058744252 @default.
- W4308189105 hasAuthorship W4308189105A5071996954 @default.
- W4308189105 hasBestOaLocation W43081891052 @default.
- W4308189105 hasConcept C185592680 @default.
- W4308189105 hasConcept C202751555 @default.
- W4308189105 hasConcept C2776635100 @default.
- W4308189105 hasConcept C2777482282 @default.
- W4308189105 hasConcept C2780764945 @default.
- W4308189105 hasConcept C55493867 @default.
- W4308189105 hasConcept C71240020 @default.
- W4308189105 hasConcept C86803240 @default.
- W4308189105 hasConceptScore W4308189105C185592680 @default.
- W4308189105 hasConceptScore W4308189105C202751555 @default.
- W4308189105 hasConceptScore W4308189105C2776635100 @default.
- W4308189105 hasConceptScore W4308189105C2777482282 @default.
- W4308189105 hasConceptScore W4308189105C2780764945 @default.
- W4308189105 hasConceptScore W4308189105C55493867 @default.
- W4308189105 hasConceptScore W4308189105C71240020 @default.
- W4308189105 hasConceptScore W4308189105C86803240 @default.
- W4308189105 hasFunder F4320321091 @default.
- W4308189105 hasFunder F4320322025 @default.
- W4308189105 hasLocation W43081891051 @default.
- W4308189105 hasLocation W43081891052 @default.
- W4308189105 hasLocation W43081891053 @default.
- W4308189105 hasOpenAccess W4308189105 @default.
- W4308189105 hasPrimaryLocation W43081891051 @default.
- W4308189105 hasRelatedWork W1969562732 @default.
- W4308189105 hasRelatedWork W1970974546 @default.
- W4308189105 hasRelatedWork W1990265936 @default.
- W4308189105 hasRelatedWork W2024000952 @default.
- W4308189105 hasRelatedWork W2111170264 @default.
- W4308189105 hasRelatedWork W2335622964 @default.
- W4308189105 hasRelatedWork W2408637706 @default.
- W4308189105 hasRelatedWork W2946316715 @default.
- W4308189105 hasRelatedWork W4288056361 @default.
- W4308189105 hasRelatedWork W4308189105 @default.
- W4308189105 isParatext "false" @default.
- W4308189105 isRetracted "false" @default.
- W4308189105 workType "article" @default.