Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308189435> ?p ?o ?g. }
- W4308189435 abstract "Isonitrile-containing natural products have garnered attention for their manifold bioactivities but are difficult to detect and isolate due to the chemical lability of the isonitrile functional group. Here, we used the isonitrile-chlorooxime ligation (INC) in a reactivity-based screening (RBS) protocol for the detection and isolation of alkaloid and terpene isonitriles in the cyanobacterium Fischerella ambigua and a marine sponge of the order Bubarida, respectively. A trifunctional probe bearing a chlorooxime moiety, a UV active aromatic moiety, and a bromine label facilitated the chemoselective reaction with isonitriles, UV-Vis spectroscopic detection, and mass spectrometric analysis. The INC-based RBS allowed for the detection, isolation, and structural elucidation of isonitriles in microgram quantities." @default.
- W4308189435 created "2022-11-09" @default.
- W4308189435 creator A5026841567 @default.
- W4308189435 creator A5030172234 @default.
- W4308189435 creator A5042160264 @default.
- W4308189435 creator A5046768635 @default.
- W4308189435 creator A5072784403 @default.
- W4308189435 creator A5074114075 @default.
- W4308189435 date "2022-12-08" @default.
- W4308189435 modified "2023-10-14" @default.
- W4308189435 title "Identification of Isonitrile‐Containing Natural Products in Complex Biological Matrices through Ligation with Chlorooximes" @default.
- W4308189435 cites W1915284561 @default.
- W4308189435 cites W1973629582 @default.
- W4308189435 cites W1975151451 @default.
- W4308189435 cites W1978333914 @default.
- W4308189435 cites W1984279608 @default.
- W4308189435 cites W1984402888 @default.
- W4308189435 cites W1990797169 @default.
- W4308189435 cites W1990922732 @default.
- W4308189435 cites W1999902909 @default.
- W4308189435 cites W2007559738 @default.
- W4308189435 cites W2020646115 @default.
- W4308189435 cites W2043257913 @default.
- W4308189435 cites W2056449282 @default.
- W4308189435 cites W2062143165 @default.
- W4308189435 cites W2066121650 @default.
- W4308189435 cites W2069005324 @default.
- W4308189435 cites W2102463229 @default.
- W4308189435 cites W2119586851 @default.
- W4308189435 cites W2238905182 @default.
- W4308189435 cites W2331507922 @default.
- W4308189435 cites W2444595687 @default.
- W4308189435 cites W2545727925 @default.
- W4308189435 cites W2894954010 @default.
- W4308189435 cites W2944209445 @default.
- W4308189435 cites W2950498822 @default.
- W4308189435 cites W2988313968 @default.
- W4308189435 cites W2996199476 @default.
- W4308189435 cites W2996227243 @default.
- W4308189435 cites W3004437038 @default.
- W4308189435 cites W3123234022 @default.
- W4308189435 cites W3130785777 @default.
- W4308189435 cites W3164026746 @default.
- W4308189435 cites W3176825707 @default.
- W4308189435 cites W4220743576 @default.
- W4308189435 cites W4235344892 @default.
- W4308189435 cites W4308189435 @default.
- W4308189435 cites W4376849582 @default.
- W4308189435 doi "https://doi.org/10.1002/chem.202203277" @default.
- W4308189435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36331430" @default.
- W4308189435 hasPublicationYear "2022" @default.
- W4308189435 type Work @default.
- W4308189435 citedByCount "5" @default.
- W4308189435 countsByYear W43081894352022 @default.
- W4308189435 countsByYear W43081894352023 @default.
- W4308189435 crossrefType "journal-article" @default.
- W4308189435 hasAuthorship W4308189435A5026841567 @default.
- W4308189435 hasAuthorship W4308189435A5030172234 @default.
- W4308189435 hasAuthorship W4308189435A5042160264 @default.
- W4308189435 hasAuthorship W4308189435A5046768635 @default.
- W4308189435 hasAuthorship W4308189435A5072784403 @default.
- W4308189435 hasAuthorship W4308189435A5074114075 @default.
- W4308189435 hasBestOaLocation W43081894351 @default.
- W4308189435 hasConcept C142724271 @default.
- W4308189435 hasConcept C149997192 @default.
- W4308189435 hasConcept C178790620 @default.
- W4308189435 hasConcept C185592680 @default.
- W4308189435 hasConcept C204787440 @default.
- W4308189435 hasConcept C21951064 @default.
- W4308189435 hasConcept C2776568683 @default.
- W4308189435 hasConcept C2776910235 @default.
- W4308189435 hasConcept C2779396153 @default.
- W4308189435 hasConcept C71240020 @default.
- W4308189435 hasConcept C71924100 @default.
- W4308189435 hasConceptScore W4308189435C142724271 @default.
- W4308189435 hasConceptScore W4308189435C149997192 @default.
- W4308189435 hasConceptScore W4308189435C178790620 @default.
- W4308189435 hasConceptScore W4308189435C185592680 @default.
- W4308189435 hasConceptScore W4308189435C204787440 @default.
- W4308189435 hasConceptScore W4308189435C21951064 @default.
- W4308189435 hasConceptScore W4308189435C2776568683 @default.
- W4308189435 hasConceptScore W4308189435C2776910235 @default.
- W4308189435 hasConceptScore W4308189435C2779396153 @default.
- W4308189435 hasConceptScore W4308189435C71240020 @default.
- W4308189435 hasConceptScore W4308189435C71924100 @default.
- W4308189435 hasFunder F4320320924 @default.
- W4308189435 hasFunder F4320332161 @default.
- W4308189435 hasFunder F4320337368 @default.
- W4308189435 hasIssue "6" @default.
- W4308189435 hasLocation W43081894351 @default.
- W4308189435 hasLocation W43081894352 @default.
- W4308189435 hasLocation W43081894353 @default.
- W4308189435 hasLocation W43081894354 @default.
- W4308189435 hasOpenAccess W4308189435 @default.
- W4308189435 hasPrimaryLocation W43081894351 @default.
- W4308189435 hasRelatedWork W1976253167 @default.
- W4308189435 hasRelatedWork W1995317016 @default.
- W4308189435 hasRelatedWork W2026612542 @default.
- W4308189435 hasRelatedWork W2085009812 @default.
- W4308189435 hasRelatedWork W2472926092 @default.