FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308190751> ?p ?o ?g. }

• W4308190751 abstract "Abstract Most variants identified in human genome-wide association studies and scans for selection are non-coding. Interpretation of these variants’ effects and understanding of the way in which they contribute to phenotypic variation and adaptation in human populations is therefore limited by our understanding of gene regulation and by the difficulty in confidently linking non-coding variants to genes. To overcome this, we developed a gene-by-gene test for population-specific selection based on combinations of regulatory variants. We extended the Q X test for polygenic selection to test for selection on regulatory variants for 17,388 protein-coding genes across 2,504 individuals. We identified 45 genes with significant evidence (FDR <0.1) for selection, including FADS1 , KHK , SULT1A2 , ITGAM , and genes in the HLA region. We further confirm that significant selection signals do correspond to plausible population-level differences in predicted expression. However, we find that very few (0.2%) genes have strong evidence for directional, population-specific selection on the component of their expression that is predicted by cis -regulatory variants. While this is consistent with most cis -regulatory variation evolving under genetic drift or stabilizing selection, it is also possible that any effects are smaller than we can detect, or that population-specific selection is driven by tissue-specific or trans effects. Our gene-level Q X score is independent of other methods for detecting selection based on genomic variation, may therefore be useful when used in combination with more traditional selection tests to specifically identify selection on regulatory variation. Overall, our results demonstrate the utility of one approach to combining population-level information with functional data to understand the evolution of gene expression." @default.
• W4308190751 created "2022-11-09" @default.
• W4308190751 creator A5043466238 @default.
• W4308190751 creator A5063643733 @default.
• W4308190751 creator A5066843648 @default.
• W4308190751 date "2022-11-04" @default.
• W4308190751 modified "2023-09-26" @default.
• W4308190751 title "A gene-level test for directional selection on gene expression" @default.
• W4308190751 cites W1963740134 @default.
• W4308190751 cites W2025253353 @default.
• W4308190751 cites W2025943989 @default.
• W4308190751 cites W2047366062 @default.
• W4308190751 cites W2057890017 @default.
• W4308190751 cites W2058191052 @default.
• W4308190751 cites W2089555306 @default.
• W4308190751 cites W2104549677 @default.
• W4308190751 cites W2109783667 @default.
• W4308190751 cites W2112900933 @default.
• W4308190751 cites W2116360795 @default.
• W4308190751 cites W2119652557 @default.
• W4308190751 cites W2128969076 @default.
• W4308190751 cites W2152799443 @default.
• W4308190751 cites W2162445884 @default.
• W4308190751 cites W2167852161 @default.
• W4308190751 cites W2168513406 @default.
• W4308190751 cites W2177180777 @default.
• W4308190751 cites W2256016639 @default.
• W4308190751 cites W2304458632 @default.
• W4308190751 cites W2523596843 @default.
• W4308190751 cites W2531014594 @default.
• W4308190751 cites W2532435486 @default.
• W4308190751 cites W2595434143 @default.
• W4308190751 cites W2596258020 @default.
• W4308190751 cites W2761160825 @default.
• W4308190751 cites W2761275051 @default.
• W4308190751 cites W2800098072 @default.
• W4308190751 cites W2800261619 @default.
• W4308190751 cites W2910264647 @default.
• W4308190751 cites W2914690976 @default.
• W4308190751 cites W2942757851 @default.
• W4308190751 cites W2949594216 @default.
• W4308190751 cites W2949902438 @default.
• W4308190751 cites W2950681580 @default.
• W4308190751 cites W2953012249 @default.
• W4308190751 cites W2981354404 @default.
• W4308190751 cites W2989874170 @default.
• W4308190751 cites W3000799818 @default.
• W4308190751 cites W3011413344 @default.
• W4308190751 cites W3016299625 @default.
• W4308190751 cites W3025060722 @default.
• W4308190751 cites W3036655856 @default.
• W4308190751 cites W3089716446 @default.
• W4308190751 cites W3208805224 @default.
• W4308190751 cites W3210675901 @default.
• W4308190751 cites W4280524058 @default.
• W4308190751 cites W4294012180 @default.
• W4308190751 cites W4310110536 @default.
• W4308190751 cites W4361868505 @default.
• W4308190751 doi "https://doi.org/10.1101/2022.11.03.515083" @default.
• W4308190751 hasPublicationYear "2022" @default.
• W4308190751 type Work @default.
• W4308190751 citedByCount "0" @default.
• W4308190751 crossrefType "posted-content" @default.
• W4308190751 hasAuthorship W4308190751A5043466238 @default.
• W4308190751 hasAuthorship W4308190751A5063643733 @default.
• W4308190751 hasAuthorship W4308190751A5066843648 @default.
• W4308190751 hasBestOaLocation W43081907511 @default.
• W4308190751 hasConcept C104317684 @default.
• W4308190751 hasConcept C119857082 @default.
• W4308190751 hasConcept C127716648 @default.
• W4308190751 hasConcept C141231307 @default.
• W4308190751 hasConcept C144024400 @default.
• W4308190751 hasConcept C149923435 @default.
• W4308190751 hasConcept C2908647359 @default.
• W4308190751 hasConcept C41008148 @default.
• W4308190751 hasConcept C54355233 @default.
• W4308190751 hasConcept C68873052 @default.
• W4308190751 hasConcept C70721500 @default.
• W4308190751 hasConcept C7386963 @default.
• W4308190751 hasConcept C81917197 @default.
• W4308190751 hasConcept C86803240 @default.
• W4308190751 hasConcept C90032942 @default.
• W4308190751 hasConcept C91779695 @default.
• W4308190751 hasConceptScore W4308190751C104317684 @default.
• W4308190751 hasConceptScore W4308190751C119857082 @default.
• W4308190751 hasConceptScore W4308190751C127716648 @default.
• W4308190751 hasConceptScore W4308190751C141231307 @default.
• W4308190751 hasConceptScore W4308190751C144024400 @default.
• W4308190751 hasConceptScore W4308190751C149923435 @default.
• W4308190751 hasConceptScore W4308190751C2908647359 @default.
• W4308190751 hasConceptScore W4308190751C41008148 @default.
• W4308190751 hasConceptScore W4308190751C54355233 @default.
• W4308190751 hasConceptScore W4308190751C68873052 @default.
• W4308190751 hasConceptScore W4308190751C70721500 @default.
• W4308190751 hasConceptScore W4308190751C7386963 @default.
• W4308190751 hasConceptScore W4308190751C81917197 @default.
• W4308190751 hasConceptScore W4308190751C86803240 @default.
• W4308190751 hasConceptScore W4308190751C90032942 @default.
• W4308190751 hasConceptScore W4308190751C91779695 @default.
• W4308190751 hasLocation W43081907511 @default.

• next