FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308192657> ?p ?o ?g. }

• W4308192657 endingPage "140189" @default.
• W4308192657 startingPage "140189" @default.
• W4308192657 abstract "• A multi-functional AIE-active photosensitizer with broad absorption and outstanding ROS sensitizing efficiency was developed. • It can be used for time- and location-dependent sequential killing of bacteria and cancer cells. • Through controlling the incubation time, it can selectively bind to the membrane of bacteria and mitochondria of cancer cells. • It exhibited potent photodynamic antibacterial performance against methicillin-resistant Staphylococcus aureus and growth retardation of solid tumors in vivo . Multi-functional photosensitizers (PSs) with time-dependent subcellular localizations for defined and multiple targets are highly desirable for smart therapy but rarely reported. Herein, a near-infrared (NIR) aggregation-induced emission (AIE)-active PS, named TBTCP , with a broad absorption band covering the whole visible spectrum and excellent reactive oxygen species (ROS) generation efficiency was designed and synthesized. Upon short time incubation, TBTCP could insert into the bacterial membrane and showed good photodynamic antibacterial performance towards both Gram-positive and Gram-negative bacteria under light irradiation. TBTCP also exhibited cancer cell selectivity in photodynamic therapy under controlled condition through TBTCP -based light-induced mitochondrial damage that activated apoptotic signaling pathways. In vivo experiments confirmed that TBTCP exhibited potent photodynamic antibacterial performance against methicillin-resistant Staphylococcus aureus (MRSA) . In cancer mice model, TBTCP -based photodynamic therapy was also effective and was superior to the widely used PS, Chlorin e6 (Ce6). This study introduced an effective and versatile PS which not only advances the clinical application of photodynamic therapy but also provides a building block for next-generation PSs." @default.
• W4308192657 created "2022-11-09" @default.
• W4308192657 creator A5018405032 @default.
• W4308192657 creator A5029109490 @default.
• W4308192657 creator A5062572385 @default.
• W4308192657 creator A5067805976 @default.
• W4308192657 creator A5078322796 @default.
• W4308192657 creator A5084300557 @default.
• W4308192657 creator A5086699090 @default.
• W4308192657 date "2023-02-01" @default.
• W4308192657 modified "2023-10-15" @default.
• W4308192657 title "From plasma membrane to mitochondria: Time-dependent photodynamic antibacterial and anticancer therapy with a near-infrared AIE-active photosensitizer" @default.
• W4308192657 cites W1484725593 @default.
• W4308192657 cites W1497532563 @default.
• W4308192657 cites W1596848781 @default.
• W4308192657 cites W1600270074 @default.
• W4308192657 cites W1987702938 @default.
• W4308192657 cites W1998776259 @default.
• W4308192657 cites W2020332850 @default.
• W4308192657 cites W2035602354 @default.
• W4308192657 cites W2055904567 @default.
• W4308192657 cites W2061294496 @default.
• W4308192657 cites W2072298860 @default.
• W4308192657 cites W2076952459 @default.
• W4308192657 cites W2080652879 @default.
• W4308192657 cites W2081183202 @default.
• W4308192657 cites W2122683221 @default.
• W4308192657 cites W2130410032 @default.
• W4308192657 cites W2134550810 @default.
• W4308192657 cites W2140145798 @default.
• W4308192657 cites W2144258933 @default.
• W4308192657 cites W2148134634 @default.
• W4308192657 cites W2562998505 @default.
• W4308192657 cites W2589379890 @default.
• W4308192657 cites W2599759920 @default.
• W4308192657 cites W2599813635 @default.
• W4308192657 cites W2601166832 @default.
• W4308192657 cites W2602000459 @default.
• W4308192657 cites W2610328326 @default.
• W4308192657 cites W2886832839 @default.
• W4308192657 cites W2887464310 @default.
• W4308192657 cites W2888586602 @default.
• W4308192657 cites W2970903700 @default.
• W4308192657 cites W2976022258 @default.
• W4308192657 cites W2980465687 @default.
• W4308192657 cites W2982593820 @default.
• W4308192657 cites W2987663519 @default.
• W4308192657 cites W3026606749 @default.
• W4308192657 cites W3030942202 @default.
• W4308192657 cites W3041473917 @default.
• W4308192657 cites W3082333872 @default.
• W4308192657 cites W3111073034 @default.
• W4308192657 cites W3111994653 @default.
• W4308192657 cites W3115778240 @default.
• W4308192657 cites W3128646645 @default.
• W4308192657 cites W3137216032 @default.
• W4308192657 cites W3174192977 @default.
• W4308192657 cites W3175052222 @default.
• W4308192657 cites W3192962027 @default.
• W4308192657 cites W3202428997 @default.
• W4308192657 cites W3209688544 @default.
• W4308192657 cites W4220966523 @default.
• W4308192657 cites W4283399879 @default.
• W4308192657 cites W4285605324 @default.
• W4308192657 doi "https://doi.org/10.1016/j.cej.2022.140189" @default.
• W4308192657 hasPublicationYear "2023" @default.
• W4308192657 type Work @default.
• W4308192657 citedByCount "3" @default.
• W4308192657 countsByYear W43081926572023 @default.
• W4308192657 crossrefType "journal-article" @default.
• W4308192657 hasAuthorship W4308192657A5018405032 @default.
• W4308192657 hasAuthorship W4308192657A5029109490 @default.
• W4308192657 hasAuthorship W4308192657A5062572385 @default.
• W4308192657 hasAuthorship W4308192657A5067805976 @default.
• W4308192657 hasAuthorship W4308192657A5078322796 @default.
• W4308192657 hasAuthorship W4308192657A5084300557 @default.
• W4308192657 hasAuthorship W4308192657A5086699090 @default.
• W4308192657 hasConcept C120665830 @default.
• W4308192657 hasConcept C121332964 @default.
• W4308192657 hasConcept C12554922 @default.
• W4308192657 hasConcept C158355884 @default.
• W4308192657 hasConcept C178790620 @default.
• W4308192657 hasConcept C185592680 @default.
• W4308192657 hasConcept C2781323092 @default.
• W4308192657 hasConcept C2781469039 @default.
• W4308192657 hasConcept C28859421 @default.
• W4308192657 hasConcept C41625074 @default.
• W4308192657 hasConcept C55493867 @default.
• W4308192657 hasConcept C62520636 @default.
• W4308192657 hasConcept C75473681 @default.
• W4308192657 hasConcept C82706917 @default.
• W4308192657 hasConcept C86803240 @default.
• W4308192657 hasConceptScore W4308192657C120665830 @default.
• W4308192657 hasConceptScore W4308192657C121332964 @default.
• W4308192657 hasConceptScore W4308192657C12554922 @default.
• W4308192657 hasConceptScore W4308192657C158355884 @default.
• W4308192657 hasConceptScore W4308192657C178790620 @default.
• W4308192657 hasConceptScore W4308192657C185592680 @default.

• next