FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308193025> ?p ?o ?g. }

• W4308193025 endingPage "106330" @default.
• W4308193025 startingPage "106330" @default.
• W4308193025 abstract "In oral squamous cell carcinoma (OSCC), macrophages are the most abundant immune cell type in the tumor microenvironment (TME). Macrophage infiltration is inversely proportional to prognosis and disease survival, particularly when these tumor-associated macrophages (TAM) assume an M2-like phenotype. This phenotype is determined by cues from the microenvironment, especially tumor cell-secreted molecules, and is associated with increased production of extracellular-matrix-degrading enzymes, angiogenic molecules and immunosuppressing cytokines. This study investigates, in vitro and in vivo, the relative contribution of OSCC cell-secreted transforming growth factor beta (TGF-β) on the phenotype of macrophages and on macrophage-facilitated tumor invasion. TCGA database shows a positive correlation between high expression of TGFB1 and macrophage infiltrate in Head and neck squamous cell carcinoma (HNSCC). THP-1 derived-macrophages were exposed to the secretome of two OSCC cell lines using two strategies to block the effects of neoplastic cell-secreted TGF-β: pre-treatment with a TGF-β receptor type I kinase inhibitor (LY364947) and antibody-mediated depletion. RT-qPCR, ELISA and flow cytometry determined macrophage phenotype after exposure to conditioned medium (CM) from H-314 (TGF-βhigh) or SCC-9 (TGF-βlow) cell lines. The influence of TGF-β on macrophage-mediated tumor cell invasion (myogel and CAM assays) and chemotaxis (Boyden chamber) was assessed using co-cultures of macrophages and OSCC cells in which macrophages were pre-conditioned with the secretome of OSCC cells in the presence and absence of LY364947. Blocking the effects of TGF-β skewed macrophages to the M1 end of the phenotype by differential effects depending on the strategy for inhibiting the influence of TGF-β and on the neoplastic cell secretome. In vitro and in vivo invasion of H-314 cell line was reduced by inhibiting TGFBR1 signaling in macrophages, whereas SCC-9 cell invasion was not affected. SCC-9/macrophage reciprocal chemotaxis were enhanced by inhibiting TGFBR1 signaling in macrophages, whereas only macrophage chemotaxis to H314 products was inhibited by inhibiting TGFBR1. In summary, blocking the effects of OSCC cell-secreted TGF-β in macrophages attenuates M2-like phenotypical traits of macrophages and can impact invasion and chemotaxis of tumor cells differentially." @default.
• W4308193025 created "2022-11-09" @default.
• W4308193025 creator A5017436055 @default.
• W4308193025 creator A5021101891 @default.
• W4308193025 creator A5060508559 @default.
• W4308193025 creator A5070231960 @default.
• W4308193025 creator A5072132101 @default.
• W4308193025 creator A5074307541 @default.
• W4308193025 date "2022-12-01" @default.
• W4308193025 modified "2023-10-02" @default.
• W4308193025 title "Influence of tumor cell-derived TGF-β on macrophage phenotype and macrophage-mediated tumor cell invasion" @default.
• W4308193025 cites W1972199574 @default.
• W4308193025 cites W1996348230 @default.
• W4308193025 cites W2018986355 @default.
• W4308193025 cites W2046425054 @default.
• W4308193025 cites W2064989764 @default.
• W4308193025 cites W2087772688 @default.
• W4308193025 cites W2097829282 @default.
• W4308193025 cites W2130229338 @default.
• W4308193025 cites W2136280424 @default.
• W4308193025 cites W2147865927 @default.
• W4308193025 cites W2158003869 @default.
• W4308193025 cites W2158112993 @default.
• W4308193025 cites W2165421711 @default.
• W4308193025 cites W2198223093 @default.
• W4308193025 cites W2201115286 @default.
• W4308193025 cites W2466464742 @default.
• W4308193025 cites W2507880739 @default.
• W4308193025 cites W2605497049 @default.
• W4308193025 cites W2605830629 @default.
• W4308193025 cites W2789325510 @default.
• W4308193025 cites W2802606717 @default.
• W4308193025 cites W2891497275 @default.
• W4308193025 cites W3004541069 @default.
• W4308193025 cites W3027286012 @default.
• W4308193025 cites W3040737854 @default.
• W4308193025 cites W3123188618 @default.
• W4308193025 cites W3134959030 @default.
• W4308193025 cites W3165172978 @default.
• W4308193025 cites W3186815806 @default.
• W4308193025 doi "https://doi.org/10.1016/j.biocel.2022.106330" @default.
• W4308193025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36343916" @default.
• W4308193025 hasPublicationYear "2022" @default.
• W4308193025 type Work @default.
• W4308193025 citedByCount "8" @default.
• W4308193025 countsByYear W43081930252023 @default.
• W4308193025 crossrefType "journal-article" @default.
• W4308193025 hasAuthorship W4308193025A5017436055 @default.
• W4308193025 hasAuthorship W4308193025A5021101891 @default.
• W4308193025 hasAuthorship W4308193025A5060508559 @default.
• W4308193025 hasAuthorship W4308193025A5070231960 @default.
• W4308193025 hasAuthorship W4308193025A5072132101 @default.
• W4308193025 hasAuthorship W4308193025A5074307541 @default.
• W4308193025 hasConcept C1491633281 @default.
• W4308193025 hasConcept C189165786 @default.
• W4308193025 hasConcept C202751555 @default.
• W4308193025 hasConcept C203014093 @default.
• W4308193025 hasConcept C2776107976 @default.
• W4308193025 hasConcept C2778690821 @default.
• W4308193025 hasConcept C2779244956 @default.
• W4308193025 hasConcept C502942594 @default.
• W4308193025 hasConcept C54355233 @default.
• W4308193025 hasConcept C553184892 @default.
• W4308193025 hasConcept C55493867 @default.
• W4308193025 hasConcept C81885089 @default.
• W4308193025 hasConcept C86803240 @default.
• W4308193025 hasConcept C8891405 @default.
• W4308193025 hasConcept C95444343 @default.
• W4308193025 hasConceptScore W4308193025C1491633281 @default.
• W4308193025 hasConceptScore W4308193025C189165786 @default.
• W4308193025 hasConceptScore W4308193025C202751555 @default.
• W4308193025 hasConceptScore W4308193025C203014093 @default.
• W4308193025 hasConceptScore W4308193025C2776107976 @default.
• W4308193025 hasConceptScore W4308193025C2778690821 @default.
• W4308193025 hasConceptScore W4308193025C2779244956 @default.
• W4308193025 hasConceptScore W4308193025C502942594 @default.
• W4308193025 hasConceptScore W4308193025C54355233 @default.
• W4308193025 hasConceptScore W4308193025C553184892 @default.
• W4308193025 hasConceptScore W4308193025C55493867 @default.
• W4308193025 hasConceptScore W4308193025C81885089 @default.
• W4308193025 hasConceptScore W4308193025C86803240 @default.
• W4308193025 hasConceptScore W4308193025C8891405 @default.
• W4308193025 hasConceptScore W4308193025C95444343 @default.
• W4308193025 hasFunder F4320320997 @default.
• W4308193025 hasLocation W43081930251 @default.
• W4308193025 hasLocation W43081930252 @default.
• W4308193025 hasOpenAccess W4308193025 @default.
• W4308193025 hasPrimaryLocation W43081930251 @default.
• W4308193025 hasRelatedWork W181678093 @default.
• W4308193025 hasRelatedWork W1993985418 @default.
• W4308193025 hasRelatedWork W2005666125 @default.
• W4308193025 hasRelatedWork W2047209980 @default.
• W4308193025 hasRelatedWork W2095433947 @default.
• W4308193025 hasRelatedWork W3017248443 @default.
• W4308193025 hasRelatedWork W3028128121 @default.
• W4308193025 hasRelatedWork W4213151053 @default.
• W4308193025 hasRelatedWork W2185732136 @default.
• W4308193025 hasRelatedWork W2396811992 @default.

• next