FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308195462> ?p ?o ?g. }

• W4308195462 endingPage "11" @default.
• W4308195462 startingPage "1" @default.
• W4308195462 abstract "Solute carrier 39A1 (SLC39A1) is an indirect zinc transporter which showed diverse tumor-related functions in different malignancies. Here, we aimed to investigate its expression and role in gastric adenocarcinoma.A retrospective gastric adenocarcinoma cohort (n = 154) was collected from our hospital to test their tissue expression of SLC39A1 through immunohistochemical staining method. After SLC39A1 overexpression or knockdown, proliferation and invasion assays were conducted for proliferation and invasion estimation, respectively. Xenograft in nude mice was used as the in vivo strategy to validate in vitro findings.Compared with adjacent stomach tissues, gastric adenocarcinoma tissues showed significantly higher SLC39A1 on both mRNA and protein levels. Higher SLC39A1 was observed in patients with larger tumor size (P=0.003) and advanced tumor stages (P < 0.001). Univariate (P=0.001) and multivariate analyses (P=0.035) confirmed the independent prognostic significance of SLC39A1 on gastric adenocarcinoma outcomes. The median survival time was 22.0 months in patients with high-SLC39A1 expression, while up to 57.0 months in those with low-SLC39A1 (P=0.001). In vitro and in vivo assays demonstrated that overexpressing SLC39A1 could promote gastric cancer growth and invasion, while silencing SLC39A1 led to opposite effects.Aberrant high-SLC39A1 expression can serve as an independent unfavorable prognostic factor for gastric adenocarcinoma. High SLC39A1 is critical for a more aggressive tumor phenotype by promoting cell proliferation and invasion. Therefore, targeting SLC39A1 may provide novel therapeutic insights." @default.
• W4308195462 created "2022-11-09" @default.
• W4308195462 creator A5011037678 @default.
• W4308195462 creator A5061917583 @default.
• W4308195462 creator A5064123030 @default.
• W4308195462 creator A5076072512 @default.
• W4308195462 creator A5085462851 @default.
• W4308195462 date "2022-11-04" @default.
• W4308195462 modified "2023-09-25" @default.
• W4308195462 title "Upregulated Solute Carrier SLC39A1 Promotes Gastric Cancer Proliferation and Indicates Unfavorable Prognosis" @default.
• W4308195462 cites W1996009589 @default.
• W4308195462 cites W1998449822 @default.
• W4308195462 cites W2009554950 @default.
• W4308195462 cites W2018238895 @default.
• W4308195462 cites W2051976288 @default.
• W4308195462 cites W2080155677 @default.
• W4308195462 cites W2097075952 @default.
• W4308195462 cites W2126188935 @default.
• W4308195462 cites W2144174915 @default.
• W4308195462 cites W2148820240 @default.
• W4308195462 cites W2344089340 @default.
• W4308195462 cites W2344119092 @default.
• W4308195462 cites W2423681796 @default.
• W4308195462 cites W2622200008 @default.
• W4308195462 cites W2743560149 @default.
• W4308195462 cites W2900107341 @default.
• W4308195462 cites W2910775131 @default.
• W4308195462 cites W2966019641 @default.
• W4308195462 cites W3047528520 @default.
• W4308195462 cites W3110149087 @default.
• W4308195462 cites W3119005666 @default.
• W4308195462 cites W3129725136 @default.
• W4308195462 cites W3203700192 @default.
• W4308195462 cites W3215839828 @default.
• W4308195462 cites W3215976679 @default.
• W4308195462 cites W4226193443 @default.
• W4308195462 doi "https://doi.org/10.1155/2022/1256021" @default.
• W4308195462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36407082" @default.
• W4308195462 hasPublicationYear "2022" @default.
• W4308195462 type Work @default.
• W4308195462 citedByCount "1" @default.
• W4308195462 countsByYear W43081954622023 @default.
• W4308195462 crossrefType "journal-article" @default.
• W4308195462 hasAuthorship W4308195462A5011037678 @default.
• W4308195462 hasAuthorship W4308195462A5061917583 @default.
• W4308195462 hasAuthorship W4308195462A5064123030 @default.
• W4308195462 hasAuthorship W4308195462A5076072512 @default.
• W4308195462 hasAuthorship W4308195462A5085462851 @default.
• W4308195462 hasBestOaLocation W43081954621 @default.
• W4308195462 hasConcept C104317684 @default.
• W4308195462 hasConcept C119056186 @default.
• W4308195462 hasConcept C121608353 @default.
• W4308195462 hasConcept C126322002 @default.
• W4308195462 hasConcept C127561419 @default.
• W4308195462 hasConcept C142724271 @default.
• W4308195462 hasConcept C143998085 @default.
• W4308195462 hasConcept C150903083 @default.
• W4308195462 hasConcept C173396325 @default.
• W4308195462 hasConcept C190283241 @default.
• W4308195462 hasConcept C204232928 @default.
• W4308195462 hasConcept C207001950 @default.
• W4308195462 hasConcept C2779422922 @default.
• W4308195462 hasConcept C2781182431 @default.
• W4308195462 hasConcept C2993283237 @default.
• W4308195462 hasConcept C502942594 @default.
• W4308195462 hasConcept C55493867 @default.
• W4308195462 hasConcept C71924100 @default.
• W4308195462 hasConcept C86803240 @default.
• W4308195462 hasConceptScore W4308195462C104317684 @default.
• W4308195462 hasConceptScore W4308195462C119056186 @default.
• W4308195462 hasConceptScore W4308195462C121608353 @default.
• W4308195462 hasConceptScore W4308195462C126322002 @default.
• W4308195462 hasConceptScore W4308195462C127561419 @default.
• W4308195462 hasConceptScore W4308195462C142724271 @default.
• W4308195462 hasConceptScore W4308195462C143998085 @default.
• W4308195462 hasConceptScore W4308195462C150903083 @default.
• W4308195462 hasConceptScore W4308195462C173396325 @default.
• W4308195462 hasConceptScore W4308195462C190283241 @default.
• W4308195462 hasConceptScore W4308195462C204232928 @default.
• W4308195462 hasConceptScore W4308195462C207001950 @default.
• W4308195462 hasConceptScore W4308195462C2779422922 @default.
• W4308195462 hasConceptScore W4308195462C2781182431 @default.
• W4308195462 hasConceptScore W4308195462C2993283237 @default.
• W4308195462 hasConceptScore W4308195462C502942594 @default.
• W4308195462 hasConceptScore W4308195462C55493867 @default.
• W4308195462 hasConceptScore W4308195462C71924100 @default.
• W4308195462 hasConceptScore W4308195462C86803240 @default.
• W4308195462 hasLocation W43081954621 @default.
• W4308195462 hasLocation W43081954622 @default.
• W4308195462 hasLocation W43081954623 @default.
• W4308195462 hasLocation W43081954624 @default.
• W4308195462 hasOpenAccess W4308195462 @default.
• W4308195462 hasPrimaryLocation W43081954621 @default.
• W4308195462 hasRelatedWork W1534048972 @default.
• W4308195462 hasRelatedWork W2024344351 @default.
• W4308195462 hasRelatedWork W2346343701 @default.
• W4308195462 hasRelatedWork W2494327966 @default.
• W4308195462 hasRelatedWork W3097942869 @default.

• next