Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308202927> ?p ?o ?g. }
- W4308202927 abstract "Protein synthesis is an essential step in gene expression during the development of mammalian preimplantation embryos. This is a complex and highly regulated process. The accuracy of the translation initiation codon is important in various gene expression programs. However, the mechanisms that regulate AUG and non-AUG codon initiation in early embryos remain poorly understood. BZW1 is a key factor in determining the mRNA translation start codon. Here, we show that BZW1 is essential for early embryonic development in mice. Bzw1-knockdown embryos fail to undergo compaction, and show decreased blastocyst formation rates. We also observe defects in the differentiation capacity and implantation potential after Bzw1 interference. Further investigation revealed that Bzw1 knockdown causes the levels of translation initiation with CUG as the start codon to increase. The decline in BZW1 levels result in a decrease in protein synthesis in preimplantation embryos, whereas the total mRNA levels are not altered. Therefore, we concluded that BZW1 contributes to protein synthesis during early embryonic development by restricting non-AUG translational initiation." @default.
- W4308202927 created "2022-11-09" @default.
- W4308202927 creator A5006548866 @default.
- W4308202927 creator A5010587223 @default.
- W4308202927 creator A5019889851 @default.
- W4308202927 creator A5023036770 @default.
- W4308202927 creator A5042769960 @default.
- W4308202927 creator A5058020733 @default.
- W4308202927 creator A5075090550 @default.
- W4308202927 creator A5080552339 @default.
- W4308202927 date "2022-11-04" @default.
- W4308202927 modified "2023-09-26" @default.
- W4308202927 title "Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation" @default.
- W4308202927 cites W1936625799 @default.
- W4308202927 cites W1975751233 @default.
- W4308202927 cites W1977817512 @default.
- W4308202927 cites W1989913942 @default.
- W4308202927 cites W1996318954 @default.
- W4308202927 cites W2010558778 @default.
- W4308202927 cites W2013126209 @default.
- W4308202927 cites W2021872598 @default.
- W4308202927 cites W2024751967 @default.
- W4308202927 cites W2038573562 @default.
- W4308202927 cites W2039541390 @default.
- W4308202927 cites W2049698548 @default.
- W4308202927 cites W2068221443 @default.
- W4308202927 cites W2068767807 @default.
- W4308202927 cites W2077143031 @default.
- W4308202927 cites W2089238459 @default.
- W4308202927 cites W2103994533 @default.
- W4308202927 cites W2123716335 @default.
- W4308202927 cites W2124467041 @default.
- W4308202927 cites W2128085251 @default.
- W4308202927 cites W2130104786 @default.
- W4308202927 cites W2139626362 @default.
- W4308202927 cites W2146339805 @default.
- W4308202927 cites W2147680328 @default.
- W4308202927 cites W2168000279 @default.
- W4308202927 cites W2413268016 @default.
- W4308202927 cites W2470303684 @default.
- W4308202927 cites W2470491860 @default.
- W4308202927 cites W2553210802 @default.
- W4308202927 cites W2619140115 @default.
- W4308202927 cites W2747899047 @default.
- W4308202927 cites W2755382809 @default.
- W4308202927 cites W2762801938 @default.
- W4308202927 cites W2768230468 @default.
- W4308202927 cites W2774246710 @default.
- W4308202927 cites W2779468157 @default.
- W4308202927 cites W2792700276 @default.
- W4308202927 cites W2834953606 @default.
- W4308202927 cites W2885547929 @default.
- W4308202927 cites W2895275740 @default.
- W4308202927 cites W2914682571 @default.
- W4308202927 cites W2971947502 @default.
- W4308202927 cites W2979707956 @default.
- W4308202927 cites W3008684703 @default.
- W4308202927 cites W3036776958 @default.
- W4308202927 cites W3041001090 @default.
- W4308202927 cites W3087266652 @default.
- W4308202927 cites W3090998674 @default.
- W4308202927 cites W3112719934 @default.
- W4308202927 cites W3119134164 @default.
- W4308202927 cites W3152846009 @default.
- W4308202927 cites W3162272076 @default.
- W4308202927 cites W3173373410 @default.
- W4308202927 cites W3195829466 @default.
- W4308202927 cites W342233364 @default.
- W4308202927 cites W4210480008 @default.
- W4308202927 cites W4233795100 @default.
- W4308202927 doi "https://doi.org/10.1038/s41467-022-34427-x" @default.
- W4308202927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36333315" @default.
- W4308202927 hasPublicationYear "2022" @default.
- W4308202927 type Work @default.
- W4308202927 citedByCount "2" @default.
- W4308202927 countsByYear W43082029272022 @default.
- W4308202927 countsByYear W43082029272023 @default.
- W4308202927 crossrefType "journal-article" @default.
- W4308202927 hasAuthorship W4308202927A5006548866 @default.
- W4308202927 hasAuthorship W4308202927A5010587223 @default.
- W4308202927 hasAuthorship W4308202927A5019889851 @default.
- W4308202927 hasAuthorship W4308202927A5023036770 @default.
- W4308202927 hasAuthorship W4308202927A5042769960 @default.
- W4308202927 hasAuthorship W4308202927A5058020733 @default.
- W4308202927 hasAuthorship W4308202927A5075090550 @default.
- W4308202927 hasAuthorship W4308202927A5080552339 @default.
- W4308202927 hasBestOaLocation W43082029271 @default.
- W4308202927 hasConcept C104317684 @default.
- W4308202927 hasConcept C105580179 @default.
- W4308202927 hasConcept C145103041 @default.
- W4308202927 hasConcept C149364088 @default.
- W4308202927 hasConcept C173396325 @default.
- W4308202927 hasConcept C196843134 @default.
- W4308202927 hasConcept C2778177303 @default.
- W4308202927 hasConcept C3675279 @default.
- W4308202927 hasConcept C39685955 @default.
- W4308202927 hasConcept C4718897 @default.
- W4308202927 hasConcept C54355233 @default.
- W4308202927 hasConcept C62493599 @default.
- W4308202927 hasConcept C86803240 @default.