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• W4308203722 abstract "Despite the availability of several COVID-19 vaccines, the incidence of infections remains a serious issue. Tunicamycin (TM), an antibiotic, inhibited tumor growth, reduced coronavirus envelope glycoprotein subunit 2 synthesis, and decreased N-linked glycosylation of coronavirus glycoproteins.Our study aimed to determine how tunicamycin interacts with certain coronavirus proteins (proteinase, protease, nsp9, ORF7a, ORF3a, ORF9b, ORF8, envelope protein, nsp2, and RBD of spike glycoprotein). Methods: Several types of chemo and bioinformatics tools were used to achieve the aim of the study. As a result, virion's effectiveness may be impaired.TM can bind to viral proteins with various degrees of affinity. The proteinase had the highest binding affinity with TM. Proteins (ORF9b, ORF8, nsp9, and RBD) were affected by unfavorable donor or acceptor bonds that impact the degree of docking. ORF7a had the weakest affinities.This antibiotic is likely to effect on SARS-CoV-2 in clinical studies.A pesar de la disponibilidad de varias vacunas contra la COVID-19, la incidencia de infecciones sigue siendo un problema grave. La tunicamicina (TM), un antibiótico, inhibió el crecimiento tumoral, redujo la síntesis de la subunidad 2 de la glicoproteína de la envoltura del coronavirus y disminuyó la glicosilación ligada a N de las glicoproteínas del coronavirus.Nuestro estudio tuvo como objetivo determinar cómo interactúa la tunicamicina con ciertas proteínas del coronavirus (proteinasa, proteasa, nsp9, ORF7a, ORF3a, ORF9b, ORF8, proteína de la envoltura, nsp2 y RBD de glicoproteína de punta).Se utilizaron varios tipos de herramientas de quimioterapia y bioinformática para lograr el objetivo del estudio. Como resultado, la eficacia del virión puede verse afectada.La TM puede unirse a proteínas virales con diversos grados de afinidad. La proteinasa tenía la mayor afinidad de unión con TM. Las proteínas (ORF9b, ORF8, nsp9 y RBD) se vieron afectadas por enlaces donantes o aceptores desfavorables que afectan el grado de acoplamiento. ORF7a tenía las afinidades más débiles.Es probable que este antibiótico tenga efecto sobre el SARS-CoV-2 en estudios clínicos." @default.
• W4308203722 created "2022-11-09" @default.
• W4308203722 creator A5011378190 @default.
• W4308203722 date "2023-01-01" @default.
• W4308203722 modified "2023-09-29" @default.
• W4308203722 title "Determination of binding affinity of tunicamycin with SARS-CoV-2 proteins: Proteinase, protease, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, envelope and RBD of spike glycoprotein" @default.
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• W4308203722 doi "https://doi.org/10.1016/j.vacun.2022.10.006" @default.
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