FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308204461> ?p ?o ?g. }

• W4308204461 endingPage "35" @default.
• W4308204461 startingPage "25" @default.
• W4308204461 abstract "Aspergilli are ubiquitous fungal pathogens associated with severe life-threatening infections, especially in immunocompromised patients. Azoles are the first line of defence in the fight against most Aspergillus -related infections. However, resistance to these therapeutic compounds has developed, which is mainly due to the existence of mutations in lanosterol 14 alpha-demethylase (Cyp51A), a crucial enzyme in the pathway that produces ergosterol and is the target of azole antifungals. Azole-based antifungal medications are ineffective because of infections brought on by azole-resistant Aspergillus species, leading to a high fatality rate. However, resistant Aspergillus isolates have also been isolated from azole-naïve patients. Global agricultural practices promote the use of azole fungicides to protect crops from phytopathogens. Usage of azole fungicides on a large scale has been linked to the development of resistance among Aspergillus species prevalent in the environment. The infections caused by these azoleresistant Aspergillus species cannot be treated by the available azole drugs, in turn leading to high morbidity and mortality rates. Thus, knowledge of the environmental drivers and comprehending the genetic basis of fungal drug resistance evolution is pertinent, considering increasing numbers of patients with COVID-19 infections who are sensitive to opportunistic fungal infections. This article emphasises the prevalence and underlying mechanisms of azole resistance in Aspergillus species, with a focus on environmental triggers and resistance development. It also highlights the need for regular surveillance of pesticide use in agriculture, detection of triazole-resistant Aspergillus species in environmental and clinical settings and development of new antifungal drugs." @default.
• W4308204461 created "2022-11-09" @default.
• W4308204461 creator A5000912883 @default.
• W4308204461 creator A5045808580 @default.
• W4308204461 creator A5060393537 @default.
• W4308204461 creator A5072359329 @default.
• W4308204461 creator A5084254415 @default.
• W4308204461 date "2022-11-22" @default.
• W4308204461 modified "2023-09-30" @default.
• W4308204461 title "Understanding the environmental drivers of clinical azole resistance in Aspergillus species" @default.
• W4308204461 cites W1514738334 @default.
• W4308204461 cites W1590793750 @default.
• W4308204461 cites W1755623111 @default.
• W4308204461 cites W1792060583 @default.
• W4308204461 cites W1832443905 @default.
• W4308204461 cites W1882064213 @default.
• W4308204461 cites W1913356548 @default.
• W4308204461 cites W1972638738 @default.
• W4308204461 cites W1979870045 @default.
• W4308204461 cites W1985390943 @default.
• W4308204461 cites W2001583229 @default.
• W4308204461 cites W2006828980 @default.
• W4308204461 cites W2010221734 @default.
• W4308204461 cites W2013000822 @default.
• W4308204461 cites W2013887545 @default.
• W4308204461 cites W2015576282 @default.
• W4308204461 cites W2021890674 @default.
• W4308204461 cites W2023843703 @default.
• W4308204461 cites W2024059428 @default.
• W4308204461 cites W2029186386 @default.
• W4308204461 cites W2035017907 @default.
• W4308204461 cites W2037438858 @default.
• W4308204461 cites W2037676380 @default.
• W4308204461 cites W2038971167 @default.
• W4308204461 cites W2041015559 @default.
• W4308204461 cites W2045304212 @default.
• W4308204461 cites W2050314426 @default.
• W4308204461 cites W2051335660 @default.
• W4308204461 cites W2057425442 @default.
• W4308204461 cites W2067409920 @default.
• W4308204461 cites W2070897511 @default.
• W4308204461 cites W2073488008 @default.
• W4308204461 cites W2074493002 @default.
• W4308204461 cites W2076653848 @default.
• W4308204461 cites W2088013043 @default.
• W4308204461 cites W2090854671 @default.
• W4308204461 cites W2091932747 @default.
• W4308204461 cites W2096246633 @default.
• W4308204461 cites W2096308348 @default.
• W4308204461 cites W2098999975 @default.
• W4308204461 cites W2099769947 @default.
• W4308204461 cites W2100341641 @default.
• W4308204461 cites W2102737995 @default.
• W4308204461 cites W2104743902 @default.
• W4308204461 cites W2105376278 @default.
• W4308204461 cites W2105484292 @default.
• W4308204461 cites W2106729042 @default.
• W4308204461 cites W2107013040 @default.
• W4308204461 cites W2108931847 @default.
• W4308204461 cites W2112204512 @default.
• W4308204461 cites W2112677154 @default.
• W4308204461 cites W2113498073 @default.
• W4308204461 cites W2115118709 @default.
• W4308204461 cites W2115511578 @default.
• W4308204461 cites W2115567523 @default.
• W4308204461 cites W2120560034 @default.
• W4308204461 cites W2121353031 @default.
• W4308204461 cites W2121353759 @default.
• W4308204461 cites W2123134253 @default.
• W4308204461 cites W2127493926 @default.
• W4308204461 cites W2133932584 @default.
• W4308204461 cites W2134794454 @default.
• W4308204461 cites W2141000189 @default.
• W4308204461 cites W2141004761 @default.
• W4308204461 cites W2141197648 @default.
• W4308204461 cites W2142912010 @default.
• W4308204461 cites W2143691385 @default.
• W4308204461 cites W2145314255 @default.
• W4308204461 cites W2146843443 @default.
• W4308204461 cites W2147104869 @default.
• W4308204461 cites W2153885552 @default.
• W4308204461 cites W2158670382 @default.
• W4308204461 cites W2159467690 @default.
• W4308204461 cites W2167177000 @default.
• W4308204461 cites W2167817685 @default.
• W4308204461 cites W2169748580 @default.
• W4308204461 cites W2261914993 @default.
• W4308204461 cites W2323294082 @default.
• W4308204461 cites W2337593808 @default.
• W4308204461 cites W2338427714 @default.
• W4308204461 cites W2409102502 @default.
• W4308204461 cites W2412706318 @default.
• W4308204461 cites W2469440494 @default.
• W4308204461 cites W2473745709 @default.
• W4308204461 cites W2523507163 @default.
• W4308204461 cites W2524621063 @default.
• W4308204461 cites W2524950357 @default.
• W4308204461 cites W2535481478 @default.

• next