Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308210367> ?p ?o ?g. }
- W4308210367 abstract "Understanding the antigenic signatures of all human coronaviruses (HCoVs) Spike (S) proteins is imperative for pan-HCoV epitopes identification and broadly effective vaccine development. To depict the currently elusive antigenic signatures of α-HCoVs S proteins, we isolated a panel of antibodies against the HCoV-229E S protein and characterized their epitopes and neutralizing potential. We found that the N-terminal domain of HCoV-229E S protein is antigenically dominant wherein an antigenic supersite is present and appears conserved in HCoV-NL63, which holds potential to serve as a pan-α-HCoVs epitope. In the receptor binding domain, a neutralizing epitope is captured in the end distal to the receptor binding site, reminiscent of the locations of the SARS-CoV-2 RBD cryptic epitopes. We also identified a neutralizing antibody that recognizes the connector domain, thus representing the first S2-directed neutralizing antibody against α-HCoVs. The unraveled HCoVs S proteins antigenic similarities and variances among genera highlight the challenges faced by pan-HCoV vaccine design while supporting the feasibility of broadly effective vaccine development against a subset of HCoVs." @default.
- W4308210367 created "2022-11-09" @default.
- W4308210367 creator A5009123964 @default.
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- W4308210367 date "2022-11-04" @default.
- W4308210367 modified "2023-10-18" @default.
- W4308210367 title "Antigenic mapping reveals sites of vulnerability on α-HCoV spike protein" @default.
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