Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308216548> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4308216548 abstract "Levodopa (L-dopa) is the gold-standard medication and the most commonly used substance in the treatment of motor complications in Parkinson's disease (PD) patients. The “Wearing-off” phenomenon is the most frequent complication developed by long-term L-dopa therapy, which results in the reemergence of PD symptoms and lower quality of life in patients. Detecting and monitoring the onset and the duration of wearing-off alongside the persistence of the symptoms, known as “delayed-on”, would enable the patients to receive the medication changes in the required time while preventing them from extravagant use of L-dopa. Home monitoring systems using inertial measurement units have enabled us to measure gait parameters in unsupervised environments. By using patients' medication diaries and their gait parameters obtained from continuous real-world data in the course of two weeks, we developed a system to identify the distorted gait spans during L-dopa therapy utilizing personalized machine learning. Our algorithm differentiates between the two states of medication in effect and the distorted gait states with the mean accuracy of 77% ± 3.37. Furthermore, through each model's feature importance, we found that maximum sensor lift was the most prominent feature affected in the distorted gait sequences. We contribute to a better understanding of the repercussions of wearing-off episodes on gait parameters during L-dopa therapy. Moreover, our proposed system facilitates clinicians in monitoring the severity of these episodes more efficiently." @default.
- W4308216548 created "2022-11-09" @default.
- W4308216548 creator A5024571000 @default.
- W4308216548 creator A5025280289 @default.
- W4308216548 creator A5076484521 @default.
- W4308216548 creator A5088002863 @default.
- W4308216548 date "2022-09-27" @default.
- W4308216548 modified "2023-09-26" @default.
- W4308216548 title "Detection of distorted gait and wearing-off phenomenon in Parkinson's disease patients during Levodopa therapy" @default.
- W4308216548 cites W1976884564 @default.
- W4308216548 cites W2013337604 @default.
- W4308216548 cites W2080453454 @default.
- W4308216548 cites W2087048290 @default.
- W4308216548 cites W2091675688 @default.
- W4308216548 cites W2135697279 @default.
- W4308216548 cites W2138535275 @default.
- W4308216548 cites W2140978740 @default.
- W4308216548 cites W2470003547 @default.
- W4308216548 cites W2783265305 @default.
- W4308216548 cites W2972934994 @default.
- W4308216548 cites W3014902804 @default.
- W4308216548 cites W3085935853 @default.
- W4308216548 cites W3086799551 @default.
- W4308216548 cites W3134641921 @default.
- W4308216548 cites W3161511225 @default.
- W4308216548 cites W3199169454 @default.
- W4308216548 cites W3216635687 @default.
- W4308216548 cites W62603772 @default.
- W4308216548 doi "https://doi.org/10.1109/bhi56158.2022.9926873" @default.
- W4308216548 hasPublicationYear "2022" @default.
- W4308216548 type Work @default.
- W4308216548 citedByCount "1" @default.
- W4308216548 countsByYear W43082165482022 @default.
- W4308216548 crossrefType "proceedings-article" @default.
- W4308216548 hasAuthorship W4308216548A5024571000 @default.
- W4308216548 hasAuthorship W4308216548A5025280289 @default.
- W4308216548 hasAuthorship W4308216548A5076484521 @default.
- W4308216548 hasAuthorship W4308216548A5088002863 @default.
- W4308216548 hasConcept C126322002 @default.
- W4308216548 hasConcept C151800584 @default.
- W4308216548 hasConcept C173906292 @default.
- W4308216548 hasConcept C1862650 @default.
- W4308216548 hasConcept C2779134260 @default.
- W4308216548 hasConcept C2779734285 @default.
- W4308216548 hasConcept C2780304432 @default.
- W4308216548 hasConcept C71924100 @default.
- W4308216548 hasConcept C99508421 @default.
- W4308216548 hasConceptScore W4308216548C126322002 @default.
- W4308216548 hasConceptScore W4308216548C151800584 @default.
- W4308216548 hasConceptScore W4308216548C173906292 @default.
- W4308216548 hasConceptScore W4308216548C1862650 @default.
- W4308216548 hasConceptScore W4308216548C2779134260 @default.
- W4308216548 hasConceptScore W4308216548C2779734285 @default.
- W4308216548 hasConceptScore W4308216548C2780304432 @default.
- W4308216548 hasConceptScore W4308216548C71924100 @default.
- W4308216548 hasConceptScore W4308216548C99508421 @default.
- W4308216548 hasLocation W43082165481 @default.
- W4308216548 hasOpenAccess W4308216548 @default.
- W4308216548 hasPrimaryLocation W43082165481 @default.
- W4308216548 hasRelatedWork W1818931447 @default.
- W4308216548 hasRelatedWork W1962709349 @default.
- W4308216548 hasRelatedWork W2009398857 @default.
- W4308216548 hasRelatedWork W2088328396 @default.
- W4308216548 hasRelatedWork W2124153782 @default.
- W4308216548 hasRelatedWork W2145276816 @default.
- W4308216548 hasRelatedWork W2337731833 @default.
- W4308216548 hasRelatedWork W3125863379 @default.
- W4308216548 hasRelatedWork W3138424302 @default.
- W4308216548 hasRelatedWork W4323649642 @default.
- W4308216548 isParatext "false" @default.
- W4308216548 isRetracted "false" @default.
- W4308216548 workType "article" @default.