Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308220046> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4308220046 abstract "Abstract Regeneration is a response mechanism to restore tissues that have been damaged or lost by mechanical or physiological insults. We are studying in the wing imaginal disc of Drosophila the regenerative response to a high dose of Ionizing Radiation (IR), which we estimate kills at least 35% of the cells. After such treatment irradiated discs are able to restore normal size and shape, indicating there is a mechanism to replace the lost cells. We have tested the role of the Jun N-terminal Kinase (JNK), Janus Kinase (JAK/STAT) and Wingless (Wg) pathways, which have been shown to promote cell proliferation in regenerating tissues. We find that there is size compensation after IR in the absence of function of these pathways, strongly suggesting that they are not necessary for the compensation. We also find that the proliferation rate is not increased after IR. We argue that after generalized death caused by IR there is not a specific mechanism to promote cell proliferation. The irradiated discs suffer a developmental delay and then resume growth at normal rate until they reach the final stereotyped size. The delay appears to be associated with a developmental reversion, as irradiated discs undergo rejuvenation towards an earlier developmental stage. The response to generalized damage is fundamentally different from that to localized damage, which requires activity of JNK and Wg." @default.
- W4308220046 created "2022-11-09" @default.
- W4308220046 creator A5034181867 @default.
- W4308220046 creator A5073060414 @default.
- W4308220046 creator A5084774743 @default.
- W4308220046 date "2022-11-04" @default.
- W4308220046 modified "2023-10-06" @default.
- W4308220046 title "Size compensation in Drosophila after generalised cell death" @default.
- W4308220046 cites W1828486192 @default.
- W4308220046 cites W1969291847 @default.
- W4308220046 cites W1987667693 @default.
- W4308220046 cites W1990665306 @default.
- W4308220046 cites W1990778876 @default.
- W4308220046 cites W1993041663 @default.
- W4308220046 cites W2009843720 @default.
- W4308220046 cites W2020271376 @default.
- W4308220046 cites W2021772999 @default.
- W4308220046 cites W2028618047 @default.
- W4308220046 cites W2047195990 @default.
- W4308220046 cites W2051917372 @default.
- W4308220046 cites W2052379228 @default.
- W4308220046 cites W2053589174 @default.
- W4308220046 cites W2062469875 @default.
- W4308220046 cites W2081092282 @default.
- W4308220046 cites W2088910085 @default.
- W4308220046 cites W2110367574 @default.
- W4308220046 cites W2117010634 @default.
- W4308220046 cites W2118609604 @default.
- W4308220046 cites W2126194853 @default.
- W4308220046 cites W2154481751 @default.
- W4308220046 cites W2161742793 @default.
- W4308220046 cites W2171572099 @default.
- W4308220046 cites W2346005039 @default.
- W4308220046 cites W2460716556 @default.
- W4308220046 cites W2511096703 @default.
- W4308220046 cites W2758190105 @default.
- W4308220046 cites W2785056002 @default.
- W4308220046 cites W2800323371 @default.
- W4308220046 cites W2921477556 @default.
- W4308220046 doi "https://doi.org/10.1101/2022.11.04.515194" @default.
- W4308220046 hasPublicationYear "2022" @default.
- W4308220046 type Work @default.
- W4308220046 citedByCount "0" @default.
- W4308220046 crossrefType "posted-content" @default.
- W4308220046 hasAuthorship W4308220046A5034181867 @default.
- W4308220046 hasAuthorship W4308220046A5073060414 @default.
- W4308220046 hasAuthorship W4308220046A5084774743 @default.
- W4308220046 hasBestOaLocation W43082200461 @default.
- W4308220046 hasConcept C104317684 @default.
- W4308220046 hasConcept C112392421 @default.
- W4308220046 hasConcept C121332964 @default.
- W4308220046 hasConcept C127716648 @default.
- W4308220046 hasConcept C171056886 @default.
- W4308220046 hasConcept C184235292 @default.
- W4308220046 hasConcept C190283241 @default.
- W4308220046 hasConcept C2780104201 @default.
- W4308220046 hasConcept C31573885 @default.
- W4308220046 hasConcept C54355233 @default.
- W4308220046 hasConcept C62112901 @default.
- W4308220046 hasConcept C62520636 @default.
- W4308220046 hasConcept C70883133 @default.
- W4308220046 hasConcept C86803240 @default.
- W4308220046 hasConcept C89611455 @default.
- W4308220046 hasConcept C91986751 @default.
- W4308220046 hasConcept C95444343 @default.
- W4308220046 hasConceptScore W4308220046C104317684 @default.
- W4308220046 hasConceptScore W4308220046C112392421 @default.
- W4308220046 hasConceptScore W4308220046C121332964 @default.
- W4308220046 hasConceptScore W4308220046C127716648 @default.
- W4308220046 hasConceptScore W4308220046C171056886 @default.
- W4308220046 hasConceptScore W4308220046C184235292 @default.
- W4308220046 hasConceptScore W4308220046C190283241 @default.
- W4308220046 hasConceptScore W4308220046C2780104201 @default.
- W4308220046 hasConceptScore W4308220046C31573885 @default.
- W4308220046 hasConceptScore W4308220046C54355233 @default.
- W4308220046 hasConceptScore W4308220046C62112901 @default.
- W4308220046 hasConceptScore W4308220046C62520636 @default.
- W4308220046 hasConceptScore W4308220046C70883133 @default.
- W4308220046 hasConceptScore W4308220046C86803240 @default.
- W4308220046 hasConceptScore W4308220046C89611455 @default.
- W4308220046 hasConceptScore W4308220046C91986751 @default.
- W4308220046 hasConceptScore W4308220046C95444343 @default.
- W4308220046 hasLocation W43082200461 @default.
- W4308220046 hasOpenAccess W4308220046 @default.
- W4308220046 hasPrimaryLocation W43082200461 @default.
- W4308220046 hasRelatedWork W1975944099 @default.
- W4308220046 hasRelatedWork W2052379228 @default.
- W4308220046 hasRelatedWork W2073473156 @default.
- W4308220046 hasRelatedWork W2082585155 @default.
- W4308220046 hasRelatedWork W2154481751 @default.
- W4308220046 hasRelatedWork W216085092 @default.
- W4308220046 hasRelatedWork W2559577439 @default.
- W4308220046 hasRelatedWork W2614658890 @default.
- W4308220046 hasRelatedWork W2765613517 @default.
- W4308220046 hasRelatedWork W3147413131 @default.
- W4308220046 isParatext "false" @default.
- W4308220046 isRetracted "false" @default.
- W4308220046 workType "article" @default.