FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308220482> ?p ?o ?g. }

• W4308220482 endingPage "107850" @default.
• W4308220482 startingPage "107850" @default.
• W4308220482 abstract "A significant amount of work has been devoted towards understanding the cellular and humoral immune responses in arthropod vectors. Although fleas (Siphonaptera) are vectors of numerous bacterial pathogens, few studies have examined how these insects defend themselves from infection. In this study, we investigated the immune defense mechanisms in the hemocoel of cat fleas (Ctenocephalides felis), currently the most important flea pest of humans and many domestic animals. Using model species of bacteria (Micrococcus luteus, Serratia marcescens, and Escherichia coli), we delivered a systemic infection and measured the following: antimicrobial activity of hemolymph, levels of free radicals resulting from the induction of oxidase-based pathways, number of circulating hemocytes, phagocytosis activity of circulating hemocytes, and in vivo bacteria killing efficiency when phagocytosis activity is limited. Our results show that the antimicrobial activity of flea hemolymph increases in response to certain species of bacteria; yet, a systemic infection with the same bacterial species did not influence levels of hydrogen peroxide (H2O2), a reactive intermediate of oxygen, at the same time. Additionally, the number of circulating hemocytes increases in response to E. coli infection, and these cells display strong phagocytic activity against this bacterium. Moreover, limiting phagocytosis by injecting polystyrene beads subsequently increases flea susceptibility to E. coli infection when compared to injury controls; however, impairing the cellular immune response itself did not increase flea susceptibility to infection when compared to untreated fleas. Overall, this work yields significant insight into how fleas interact with bacterial pathogens in their hemocoel, and suggests that cellular and humoral immune responses cooperate to combat systemic bacterial infections." @default.
• W4308220482 created "2022-11-09" @default.
• W4308220482 creator A5001275170 @default.
• W4308220482 creator A5010613128 @default.
• W4308220482 creator A5023105279 @default.
• W4308220482 creator A5026862474 @default.
• W4308220482 creator A5039719715 @default.
• W4308220482 date "2022-11-01" @default.
• W4308220482 modified "2023-09-24" @default.
• W4308220482 title "Immune defense mechanisms against a systemic bacterial infection in the cat flea (Ctenocephalides felis)" @default.
• W4308220482 cites W1891228765 @default.
• W4308220482 cites W1959453495 @default.
• W4308220482 cites W1967325223 @default.
• W4308220482 cites W1970926974 @default.
• W4308220482 cites W1980132403 @default.
• W4308220482 cites W1994181567 @default.
• W4308220482 cites W2001119494 @default.
• W4308220482 cites W2002356275 @default.
• W4308220482 cites W2004102173 @default.
• W4308220482 cites W2005623232 @default.
• W4308220482 cites W2005751717 @default.
• W4308220482 cites W2009034765 @default.
• W4308220482 cites W2009604662 @default.
• W4308220482 cites W2015655735 @default.
• W4308220482 cites W2016414250 @default.
• W4308220482 cites W2016580331 @default.
• W4308220482 cites W2018624477 @default.
• W4308220482 cites W2027868871 @default.
• W4308220482 cites W2045704202 @default.
• W4308220482 cites W2063526946 @default.
• W4308220482 cites W2065813900 @default.
• W4308220482 cites W2072090415 @default.
• W4308220482 cites W2089164117 @default.
• W4308220482 cites W2093765409 @default.
• W4308220482 cites W2104480040 @default.
• W4308220482 cites W2119512070 @default.
• W4308220482 cites W2124792221 @default.
• W4308220482 cites W2138018148 @default.
• W4308220482 cites W2161221936 @default.
• W4308220482 cites W2171419510 @default.
• W4308220482 cites W2173955333 @default.
• W4308220482 cites W2180206969 @default.
• W4308220482 cites W2198497392 @default.
• W4308220482 cites W2198729757 @default.
• W4308220482 cites W2331907770 @default.
• W4308220482 cites W2431158285 @default.
• W4308220482 cites W2462354555 @default.
• W4308220482 cites W2575496210 @default.
• W4308220482 cites W2606186391 @default.
• W4308220482 cites W2741708810 @default.
• W4308220482 cites W2765383098 @default.
• W4308220482 cites W2895696125 @default.
• W4308220482 cites W2937787302 @default.
• W4308220482 cites W2972347933 @default.
• W4308220482 cites W3105392132 @default.
• W4308220482 cites W3173617798 @default.
• W4308220482 doi "https://doi.org/10.1016/j.jip.2022.107850" @default.
• W4308220482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36347390" @default.
• W4308220482 hasPublicationYear "2022" @default.
• W4308220482 type Work @default.
• W4308220482 citedByCount "0" @default.
• W4308220482 crossrefType "journal-article" @default.
• W4308220482 hasAuthorship W4308220482A5001275170 @default.
• W4308220482 hasAuthorship W4308220482A5010613128 @default.
• W4308220482 hasAuthorship W4308220482A5023105279 @default.
• W4308220482 hasAuthorship W4308220482A5026862474 @default.
• W4308220482 hasAuthorship W4308220482A5039719715 @default.
• W4308220482 hasConcept C100068826 @default.
• W4308220482 hasConcept C149635348 @default.
• W4308220482 hasConcept C160448771 @default.
• W4308220482 hasConcept C18903297 @default.
• W4308220482 hasConcept C203014093 @default.
• W4308220482 hasConcept C2775983634 @default.
• W4308220482 hasConcept C2776347271 @default.
• W4308220482 hasConcept C2776683811 @default.
• W4308220482 hasConcept C2777786777 @default.
• W4308220482 hasConcept C2779254346 @default.
• W4308220482 hasConcept C2779489039 @default.
• W4308220482 hasConcept C2779904517 @default.
• W4308220482 hasConcept C41008148 @default.
• W4308220482 hasConcept C4937899 @default.
• W4308220482 hasConcept C523546767 @default.
• W4308220482 hasConcept C540938839 @default.
• W4308220482 hasConcept C54355233 @default.
• W4308220482 hasConcept C86803240 @default.
• W4308220482 hasConcept C8891405 @default.
• W4308220482 hasConcept C89423630 @default.
• W4308220482 hasConcept C90856448 @default.
• W4308220482 hasConceptScore W4308220482C100068826 @default.
• W4308220482 hasConceptScore W4308220482C149635348 @default.
• W4308220482 hasConceptScore W4308220482C160448771 @default.
• W4308220482 hasConceptScore W4308220482C18903297 @default.
• W4308220482 hasConceptScore W4308220482C203014093 @default.
• W4308220482 hasConceptScore W4308220482C2775983634 @default.
• W4308220482 hasConceptScore W4308220482C2776347271 @default.
• W4308220482 hasConceptScore W4308220482C2776683811 @default.
• W4308220482 hasConceptScore W4308220482C2777786777 @default.
• W4308220482 hasConceptScore W4308220482C2779254346 @default.

• next