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• W4308223055 endingPage "101674" @default.
• W4308223055 startingPage "101674" @default.
• W4308223055 abstract "Protein, nucleic acid, and small-molecule drugs frequently require chemical modification with polymers such as polyethylene glycol (PEG), to increase their in vivo circulation time and reduce their immunogenicity. Previously, we developed low-immunogenic zwitterionic polycarboxybetaine (PCB) to replace PEGylation. Herein, we delineate the design principles of zwitterionic polypeptide to mimic PCB. These studies establish an EKP polypeptide composed of glutamic acid (E), lysine (K), and proline (P) as a low-immunogenic, unstructured, zwitterionic peptide. Then, we demonstrate EKP peptide as a genetically encodable fusion protein platform. The unique zwitterionic design ensures high hydration, thereby increasing hydrodynamic size and improving stability. EKP fusion proteins achieve prolonged circulation, low immunogenicity, and maintained circulation time over multiple injections, thus avoiding accelerating blood clearance (ABC). Its performance substantiates EKP as a valuable platform technology for drugs and biologics." @default.
• W4308223055 created "2022-11-09" @default.
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• W4308223055 date "2022-12-01" @default.
• W4308223055 modified "2023-10-04" @default.
• W4308223055 title "A low-immunogenic genetically-fusible zwitterionic polypeptide" @default.
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• W4308223055 doi "https://doi.org/10.1016/j.nantod.2022.101674" @default.
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