Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308231347> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4308231347 abstract "Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) infection is one of the most difficult infections we have to treat. Linezolid is one of the effective treatment options for refractory MRSA infections. There are cases where we are forced to use long-term linezolid treatment for refractory MRSA infections. Objective To discuss the evolution of Linezolid resistance factors in clinical isolates of MRSA. Methods We investigated 16 MRSA isolated from a patient treated with linezolid for a long period of 75 days. We performed antibiotic susceptibility test, 23S rRNA genes sequencing analysis, Pulsed-field gel electrophoresis. Results MRSA isolates were susceptible to linezolid before the start of treatment, but became less susceptible by prolonged treatment. The 23S rRNA sequencing analysis of linezolid-resistant strains that appeared 17 days after the start of treatment with linezolid revealed that all resistant MRSA had the G2576T substitution (Escherichia coli 23S rRNA gene number). The number of copies of this mutation increased with the use of linezolid. Conclusion Long-term use of linezolid in a patient or reuse of linezolid in a patient who has been previously treated with linezolid can lead to the emerging of linezolid-resistant MRSA in the host." @default.
- W4308231347 created "2022-11-09" @default.
- W4308231347 creator A5007569689 @default.
- W4308231347 creator A5058975403 @default.
- W4308231347 creator A5071823817 @default.
- W4308231347 date "2022-11-03" @default.
- W4308231347 modified "2023-10-17" @default.
- W4308231347 title "Increased copy number of 23S ribosomal RNA gene with point mutation in MRSA associated with linezolid resistance in a patient treated with long-term linezolid" @default.
- W4308231347 cites W1861281388 @default.
- W4308231347 cites W1966956568 @default.
- W4308231347 cites W2002345058 @default.
- W4308231347 cites W2011790880 @default.
- W4308231347 cites W2064227079 @default.
- W4308231347 cites W2075355440 @default.
- W4308231347 cites W2092196558 @default.
- W4308231347 cites W2098651487 @default.
- W4308231347 cites W2099194418 @default.
- W4308231347 cites W2109899161 @default.
- W4308231347 cites W2116234047 @default.
- W4308231347 cites W2121543056 @default.
- W4308231347 cites W2129260125 @default.
- W4308231347 cites W2144908107 @default.
- W4308231347 cites W2154440790 @default.
- W4308231347 cites W2155315480 @default.
- W4308231347 cites W2158473605 @default.
- W4308231347 cites W2198367621 @default.
- W4308231347 doi "https://doi.org/10.21203/rs.3.rs-2217318/v1" @default.
- W4308231347 hasPublicationYear "2022" @default.
- W4308231347 type Work @default.
- W4308231347 citedByCount "0" @default.
- W4308231347 crossrefType "posted-content" @default.
- W4308231347 hasAuthorship W4308231347A5007569689 @default.
- W4308231347 hasAuthorship W4308231347A5058975403 @default.
- W4308231347 hasAuthorship W4308231347A5071823817 @default.
- W4308231347 hasBestOaLocation W43082313471 @default.
- W4308231347 hasConcept C104317684 @default.
- W4308231347 hasConcept C114851261 @default.
- W4308231347 hasConcept C2778980435 @default.
- W4308231347 hasConcept C2779489039 @default.
- W4308231347 hasConcept C2781414143 @default.
- W4308231347 hasConcept C40749294 @default.
- W4308231347 hasConcept C501593827 @default.
- W4308231347 hasConcept C523546767 @default.
- W4308231347 hasConcept C54355233 @default.
- W4308231347 hasConcept C67705224 @default.
- W4308231347 hasConcept C71924100 @default.
- W4308231347 hasConcept C86803240 @default.
- W4308231347 hasConcept C88478588 @default.
- W4308231347 hasConcept C89423630 @default.
- W4308231347 hasConceptScore W4308231347C104317684 @default.
- W4308231347 hasConceptScore W4308231347C114851261 @default.
- W4308231347 hasConceptScore W4308231347C2778980435 @default.
- W4308231347 hasConceptScore W4308231347C2779489039 @default.
- W4308231347 hasConceptScore W4308231347C2781414143 @default.
- W4308231347 hasConceptScore W4308231347C40749294 @default.
- W4308231347 hasConceptScore W4308231347C501593827 @default.
- W4308231347 hasConceptScore W4308231347C523546767 @default.
- W4308231347 hasConceptScore W4308231347C54355233 @default.
- W4308231347 hasConceptScore W4308231347C67705224 @default.
- W4308231347 hasConceptScore W4308231347C71924100 @default.
- W4308231347 hasConceptScore W4308231347C86803240 @default.
- W4308231347 hasConceptScore W4308231347C88478588 @default.
- W4308231347 hasConceptScore W4308231347C89423630 @default.
- W4308231347 hasLocation W43082313471 @default.
- W4308231347 hasOpenAccess W4308231347 @default.
- W4308231347 hasPrimaryLocation W43082313471 @default.
- W4308231347 hasRelatedWork W2044054745 @default.
- W4308231347 hasRelatedWork W2088113134 @default.
- W4308231347 hasRelatedWork W2094925284 @default.
- W4308231347 hasRelatedWork W2113647066 @default.
- W4308231347 hasRelatedWork W2119880192 @default.
- W4308231347 hasRelatedWork W2155006677 @default.
- W4308231347 hasRelatedWork W2167594496 @default.
- W4308231347 hasRelatedWork W2382345126 @default.
- W4308231347 hasRelatedWork W3094895073 @default.
- W4308231347 hasRelatedWork W4283323294 @default.
- W4308231347 isParatext "false" @default.
- W4308231347 isRetracted "false" @default.
- W4308231347 workType "article" @default.