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• W4308231364 abstract "Abstract Perception of our linear motion – heading – is critical for postural control, gait, and locomotion, and it is impaired in Parkinson’s Disease (PD). Deep brain stimulation (DBS) has variable effects on vestibular heading perception, depending on the location of the electrodes within the subthalamic nucleus (STN). Here, we aimed to find the anatomical correlates of heading perception in PD. 14 PD participants with bilateral STN DBS participated in a two-alternative forced-choice discrimination experiment where a motion platform delivered translational forward movements with a heading angle varying between 0 and 30 degrees to the left or to the right (with respect to the straight-ahead direction). Using psychometric curves, we derived the heading discrimination threshold angle of each patient from the response data. We also created patient-specific DBS models and calculated the percentages of stimulated axonal pathways that are anatomically adjacent to the STN and known to play a major role in vestibular information processing. We performed correlation analyses to investigate the extent of these white matter tracts’ involvement in heading perception. Significant positive correlations were identified between improved heading discrimination for rightward heading and the percentage of activated streamlines of the contralateral hyperdirect, pallido-subthalamic, and subthalamo-pallidal pathways. The hyperdirect pathways is thought to provide top-down control over STN connections to the cerebellum. In addition, STN may also antidromically activate collaterals of hyperdirect pathway that projects to the precerebellar pontine nuclei. In select cases there was strong activation of the cerebello-thalamic projections, but it was not consistently present in all participants. Large volumetric overlap between the volume of tissue activation and the STN in the left hemisphere positively impacted rightward heading perception. Altogether, the results suggest heavy involvement of basal ganglia cerebellar network in STN induced modulation of vestibular heading perception in PD." @default.
• W4308231364 created "2022-11-09" @default.
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• W4308231364 date "2022-11-03" @default.
• W4308231364 modified "2023-10-16" @default.
• W4308231364 title "Does vestibular motion perception correlate with axonal pathways stimulated by STN DBS in Parkinson's disease?" @default.
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• W4308231364 doi "https://doi.org/10.21203/rs.3.rs-2170257/v1" @default.
• W4308231364 hasPublicationYear "2022" @default.
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