FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308231888> ?p ?o ?g. }

• W4308231888 abstract "Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 loss of function (LOF) mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous LOF mutations in TP53 and activation of c-MET occur in ~ 20% of human HCCs, and these patients show a poor prognosis. Importantly, we found that concomitant deletion of Trp53 and overexpression of c-MET (c-MET/sgp53) in the mouse liver led to HCC formation in vivo . Consistent with human HCCs, RNAseq showed that c-MET/sgp53 mouse HCCs were characterized by activated c-MET and Ras/MAPK cascades and increased tumor cell proliferation. Subsequently, a stably passaged cell line derived from a c-MET/sgp53 HCC and corresponding subcutaneous xenografts were generated. Also, in silico analysis suggested that the MEK inhibitor trametinib has a higher inhibition score in TP53 null human HCC cell lines, which was validated experimentally. We consistently found that trametinib effectively inhibited the growth of c-MET/sgp53 HCC cells and xenografts, supporting the possible usefulness of this drug for treating human HCCs with TP53 -null mutations. Altogether, our study demonstrates that loss of TP53 cooperates with c-MET to drive hepatocarcinogenesis in vivo. The c-MET/sgp53 mouse model and derived HCC cell lines represent novel and useful preclinical tools to study hepatocarcinogenesis in the TP53 null background." @default.
• W4308231888 created "2022-11-09" @default.
• W4308231888 creator A5005522080 @default.
• W4308231888 creator A5014261754 @default.
• W4308231888 creator A5038378719 @default.
• W4308231888 creator A5040373155 @default.
• W4308231888 creator A5041156426 @default.
• W4308231888 creator A5065789169 @default.
• W4308231888 creator A5068628314 @default.
• W4308231888 creator A5071191729 @default.
• W4308231888 creator A5076680617 @default.
• W4308231888 creator A5088888083 @default.
• W4308231888 creator A5091038323 @default.
• W4308231888 date "2022-11-03" @default.
• W4308231888 modified "2023-10-12" @default.
• W4308231888 title "Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis" @default.
• W4308231888 cites W1964501820 @default.
• W4308231888 cites W1972389653 @default.
• W4308231888 cites W1979107338 @default.
• W4308231888 cites W2004273407 @default.
• W4308231888 cites W2029949793 @default.
• W4308231888 cites W2042571415 @default.
• W4308231888 cites W2084831115 @default.
• W4308231888 cites W2088629624 @default.
• W4308231888 cites W2089298112 @default.
• W4308231888 cites W2103119762 @default.
• W4308231888 cites W2111456306 @default.
• W4308231888 cites W2119771879 @default.
• W4308231888 cites W2123014930 @default.
• W4308231888 cites W2126679757 @default.
• W4308231888 cites W2163521695 @default.
• W4308231888 cites W2294090452 @default.
• W4308231888 cites W2406250479 @default.
• W4308231888 cites W2462145367 @default.
• W4308231888 cites W2473185292 @default.
• W4308231888 cites W2620651944 @default.
• W4308231888 cites W2625559053 @default.
• W4308231888 cites W2782207466 @default.
• W4308231888 cites W2891814285 @default.
• W4308231888 cites W2912773535 @default.
• W4308231888 cites W2944267355 @default.
• W4308231888 cites W2999444600 @default.
• W4308231888 cites W3036393416 @default.
• W4308231888 cites W3097506568 @default.
• W4308231888 cites W3100629716 @default.
• W4308231888 cites W3127850202 @default.
• W4308231888 cites W3128646645 @default.
• W4308231888 cites W3141148781 @default.
• W4308231888 doi "https://doi.org/10.21203/rs.3.rs-2176178/v1" @default.
• W4308231888 hasPublicationYear "2022" @default.
• W4308231888 type Work @default.
• W4308231888 citedByCount "0" @default.
• W4308231888 crossrefType "posted-content" @default.
• W4308231888 hasAuthorship W4308231888A5005522080 @default.
• W4308231888 hasAuthorship W4308231888A5014261754 @default.
• W4308231888 hasAuthorship W4308231888A5038378719 @default.
• W4308231888 hasAuthorship W4308231888A5040373155 @default.
• W4308231888 hasAuthorship W4308231888A5041156426 @default.
• W4308231888 hasAuthorship W4308231888A5065789169 @default.
• W4308231888 hasAuthorship W4308231888A5068628314 @default.
• W4308231888 hasAuthorship W4308231888A5071191729 @default.
• W4308231888 hasAuthorship W4308231888A5076680617 @default.
• W4308231888 hasAuthorship W4308231888A5088888083 @default.
• W4308231888 hasAuthorship W4308231888A5091038323 @default.
• W4308231888 hasBestOaLocation W43082318881 @default.
• W4308231888 hasConcept C104317684 @default.
• W4308231888 hasConcept C207001950 @default.
• W4308231888 hasConcept C2778019345 @default.
• W4308231888 hasConcept C2779314089 @default.
• W4308231888 hasConcept C501734568 @default.
• W4308231888 hasConcept C502942594 @default.
• W4308231888 hasConcept C54355233 @default.
• W4308231888 hasConcept C62112901 @default.
• W4308231888 hasConcept C81885089 @default.
• W4308231888 hasConcept C86803240 @default.
• W4308231888 hasConceptScore W4308231888C104317684 @default.
• W4308231888 hasConceptScore W4308231888C207001950 @default.
• W4308231888 hasConceptScore W4308231888C2778019345 @default.
• W4308231888 hasConceptScore W4308231888C2779314089 @default.
• W4308231888 hasConceptScore W4308231888C501734568 @default.
• W4308231888 hasConceptScore W4308231888C502942594 @default.
• W4308231888 hasConceptScore W4308231888C54355233 @default.
• W4308231888 hasConceptScore W4308231888C62112901 @default.
• W4308231888 hasConceptScore W4308231888C81885089 @default.
• W4308231888 hasConceptScore W4308231888C86803240 @default.
• W4308231888 hasLocation W43082318881 @default.
• W4308231888 hasOpenAccess W4308231888 @default.
• W4308231888 hasPrimaryLocation W43082318881 @default.
• W4308231888 hasRelatedWork W1518480265 @default.
• W4308231888 hasRelatedWork W2016528526 @default.
• W4308231888 hasRelatedWork W2071058106 @default.
• W4308231888 hasRelatedWork W2393123779 @default.
• W4308231888 hasRelatedWork W2414803427 @default.
• W4308231888 hasRelatedWork W2556053653 @default.
• W4308231888 hasRelatedWork W2561790885 @default.
• W4308231888 hasRelatedWork W2578222789 @default.
• W4308231888 hasRelatedWork W3011804615 @default.
• W4308231888 hasRelatedWork W4241713775 @default.
• W4308231888 isParatext "false" @default.
• W4308231888 isRetracted "false" @default.

• next