FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308253308> ?p ?o ?g. }

• W4308253308 endingPage "039463202211374" @default.
• W4308253308 startingPage "039463202211374" @default.
• W4308253308 abstract "Objective Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem with high prevalence and morbidity associated with obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and dyslipidemia. Nano-formulation of luteolin with Zn oxide in the form of Lut/ZnO NPs may improve the anti-diabetic property of each alone and ameliorate the insulin resistance thus management of NAFLD. This study aimed to measure the efficiency of Lut/ZnO NPs against insulin resistance coupled with NAFLD and T2DM. Methods A diabetic rat model with NAFLD was induced by a high-fat diet and streptozotocin (30 mg/kg I.P). Serum diabetogenic markers levels, lipid profile, and activity of liver enzymes were measured beside liver oxidative stress markers. Moreover, the hepatic expressions of PI3K/AKT/FoxO1/SERBP1c as well as heme oxygenase-1 were measured beside the histopathological examination. Results Lut/ZnO NPs treatment effectively reduced hyperglycemia, hyperinsulinemia, and ameliorated insulin resistance. Additionally, Lut/ZnO NPs improved the hepatic functions, the antioxidant system, and reduced the oxidative stress markers. Furthermore, the lipid load in the liver, as well as the circulating TG and TC, was minified via the suppression of lipogenesis and gluconeogenesis. Moreover, Lut/ZnO NPs activated the PI3K/AKT signaling pathway, hence inactivating FoxO1, therefore enhancing the hepatic cells’ insulin sensitivity. Conclusion Lut/ZnO NPs have a hepatoprotective effect and may relieve the progression of NAFLD by alleviating insulin resistance, ameliorating the antioxidant status, and regulating the insulin signal pathway." @default.
• W4308253308 created "2022-11-09" @default.
• W4308253308 creator A5043100793 @default.
• W4308253308 creator A5072982533 @default.
• W4308253308 creator A5073675230 @default.
• W4308253308 date "2022-01-01" @default.
• W4308253308 modified "2023-10-06" @default.
• W4308253308 title "Luteolin loaded on zinc oxide nanoparticles ameliorates non-alcoholic fatty liver disease associated with insulin resistance in diabetic rats <i>via</i> regulation of PI3K/AKT/FoxO1 pathway" @default.
• W4308253308 cites W134160155 @default.
• W4308253308 cites W134350491 @default.
• W4308253308 cites W1503760388 @default.
• W4308253308 cites W1575245978 @default.
• W4308253308 cites W1850330438 @default.
• W4308253308 cites W1946263363 @default.
• W4308253308 cites W1985592156 @default.
• W4308253308 cites W1999617321 @default.
• W4308253308 cites W2035224243 @default.
• W4308253308 cites W2037806158 @default.
• W4308253308 cites W2060709481 @default.
• W4308253308 cites W2094166298 @default.
• W4308253308 cites W2095591310 @default.
• W4308253308 cites W2098915888 @default.
• W4308253308 cites W2107277218 @default.
• W4308253308 cites W2107314043 @default.
• W4308253308 cites W2116516144 @default.
• W4308253308 cites W2119654384 @default.
• W4308253308 cites W2127258766 @default.
• W4308253308 cites W2128635872 @default.
• W4308253308 cites W2138289665 @default.
• W4308253308 cites W2154774609 @default.
• W4308253308 cites W2156933665 @default.
• W4308253308 cites W2160234571 @default.
• W4308253308 cites W2166788192 @default.
• W4308253308 cites W2172053375 @default.
• W4308253308 cites W2192080449 @default.
• W4308253308 cites W2260488093 @default.
• W4308253308 cites W2263023695 @default.
• W4308253308 cites W2265357505 @default.
• W4308253308 cites W2266929960 @default.
• W4308253308 cites W2291173445 @default.
• W4308253308 cites W2386266593 @default.
• W4308253308 cites W2580767461 @default.
• W4308253308 cites W2600157301 @default.
• W4308253308 cites W2607031541 @default.
• W4308253308 cites W2765141694 @default.
• W4308253308 cites W2793018507 @default.
• W4308253308 cites W2799409025 @default.
• W4308253308 cites W2806715106 @default.
• W4308253308 cites W2807936349 @default.
• W4308253308 cites W2810177111 @default.
• W4308253308 cites W2837512072 @default.
• W4308253308 cites W2882993121 @default.
• W4308253308 cites W2893613755 @default.
• W4308253308 cites W2895314084 @default.
• W4308253308 cites W2895627668 @default.
• W4308253308 cites W2899043265 @default.
• W4308253308 cites W2912976592 @default.
• W4308253308 cites W2917968580 @default.
• W4308253308 cites W2936596869 @default.
• W4308253308 cites W2951521383 @default.
• W4308253308 cites W2953846051 @default.
• W4308253308 cites W2963543751 @default.
• W4308253308 cites W2969073805 @default.
• W4308253308 cites W2988567344 @default.
• W4308253308 cites W2994832972 @default.
• W4308253308 cites W2996129490 @default.
• W4308253308 cites W2996186141 @default.
• W4308253308 cites W3014938285 @default.
• W4308253308 cites W3024046119 @default.
• W4308253308 cites W3025811843 @default.
• W4308253308 cites W3032995302 @default.
• W4308253308 cites W3044711850 @default.
• W4308253308 cites W3088141479 @default.
• W4308253308 cites W3092160605 @default.
• W4308253308 cites W3094167812 @default.
• W4308253308 cites W3109242624 @default.
• W4308253308 cites W3127370138 @default.
• W4308253308 cites W3198005949 @default.
• W4308253308 cites W3205178377 @default.
• W4308253308 cites W3217575668 @default.
• W4308253308 cites W4200042401 @default.
• W4308253308 cites W4200076301 @default.
• W4308253308 cites W4205309789 @default.
• W4308253308 cites W4210798379 @default.
• W4308253308 cites W4225164822 @default.
• W4308253308 cites W4225529725 @default.
• W4308253308 cites W4225899878 @default.
• W4308253308 cites W4291114109 @default.
• W4308253308 doi "https://doi.org/10.1177/03946320221137435" @default.
• W4308253308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36319192" @default.
• W4308253308 hasPublicationYear "2022" @default.
• W4308253308 type Work @default.
• W4308253308 citedByCount "8" @default.
• W4308253308 countsByYear W43082533082022 @default.
• W4308253308 countsByYear W43082533082023 @default.
• W4308253308 crossrefType "journal-article" @default.
• W4308253308 hasAuthorship W4308253308A5043100793 @default.
• W4308253308 hasAuthorship W4308253308A5072982533 @default.

• next