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• W4308257445 startingPage "e16" @default.
• W4308257445 abstract "The important role of retrogenes in genome evolution and species differentiation is becoming increasingly accepted. One synapomorphy among cyprinodontoid fish is a retrotransposed version of a long-wavelength sensitive (LWS) opsin gene, LWS-R, within an intron of the gephyrin (GPHN) gene. These two genes display opposing orientations. It had been speculated that LWS-R hijacks the cis-regulatory elements of GPHN for transcription, but whether their expression is correlated had remained unclear. Here, in silico predictions identified putative promoters upstream of the translation start site of LWS-R, indicating that its transcription is driven by its own promoter rather than by the GPHN promoter. However, consistent expression ratios of LWS-R:GPHN in the eyeball and brain of fishes indicate that the respective gene transcriptions are correlated. Co-expression is potentially modulated by histone exchange during GPHN transcription. Two isoforms were detected in this study, i.e., intron-free and intron-retaining. Intron-free LWS-R was only expressed in the eyeball of fishes, whereas intron-retaining LWS-R occurred in both eyeball and brain. Expression of vision-associated LWS-R beyond the eyeball supports that it is co-expressed with more ubiquitous GPHN." @default.
• W4308257445 created "2022-11-09" @default.
• W4308257445 creator A5059484251 @default.
• W4308257445 date "2022-01-01" @default.
• W4308257445 modified "2023-09-29" @default.
• W4308257445 title "Correlated Expression of the Opsin Retrogene LWS-R and its Host Gene in Two Poeciliid Fishes." @default.
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• W4308257445 doi "https://doi.org/10.6620/zs.2022.61-16" @default.
• W4308257445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36330033" @default.
• W4308257445 hasPublicationYear "2022" @default.
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