FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308258980> ?p ?o ?g. }

• W4308258980 abstract "Abstract Magneto- and Electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG systems the sensors are offset from the scalp, which limits the signal-to-noise ratio (SNR) and thereby the sensitivity to activity from deep structures such as the hippocampus. This effect is amplified in children, for whom adult-sized fixed-helmet systems are typically too big. Moreover, ictal recordings with fixed-helmet systems are problematic because of limited movement tolerance. Optically Pumped Magnetometers (OPMs) can be placed directly on the scalp, thereby improving SNR and consequently the sensitivity to, and localisation accuracy of, epileptiform activity. In addition, recording during seizures becomes feasible with these wearable sensors. We aimed to demonstrate these advantages of OPMs in a clinical population. Three adults with known weak sources of interictal epileptiform discharges (IEDs), along with three children with focal epilepsy and one adult with frequent seizures underwent MEG recordings using a 12-channel OPM-system and a 306-channel cryogen-based whole-head system. Performance of the two systems was compared in terms of IED-rate and SNR. In one patient the OPMs detected IEDs that were not found with the SQUID-system. In one patient the spike yield was higher for the OPM data (9.00 versus 6.76), with negligible difference in SNR compared to the SQUID data (3.85 versus 3.93; U = -2.86, d = -0.14). This was also the case for a patient with a spike yield that was comparable to that for the SQUID data (after accounting for unilateral coverage with the OPMs; SNR 4.47 versus 4.57; U = -3.81, d = -0.14). For one patient the spike yield (11.03 versus 24.50) and SNR (4.39 versus 4.05; U = 9.53, d = -0.36) were both lower for the OPMs. In two patients no IEDs were found with either system. Importantly, the wearability of OPMs enabled the recording of seizure activity in a patient with hyperkinetic movements during the seizure. The observed ictal onset and semiology were in agreement with previous video- and stereo-EEG recordings. Overall, OPM data were very much comparable to those obtained with a cryogenic system: OPMs outperformed SQUIDs for two of the four patients with IEDs, with either a higher spike yield, or an ability to detect IEDs that were not observable in the SQUID data. For three patients the SNRs of IEDs were (slightly) lower in the OPM data than in the SQUID data, but with negligible effect sizes for two of these patients. The relatively cheap technology, in combination with reduced running and maintenance costs, means that OPM-based MEG could be used more widely than current MEG systems, and may become an affordable alternative to scalp EEG, with the potential benefits of increased spatial accuracy, reduced sensitivity to volume conduction/field spread, and increased sensitivity to deep sources. Wearable MEG thus provides an unprecedented opportunity for epilepsy, and given its patient-friendliness, we envisage that it will not only be used for presurgical evaluation of epilepsy patients, but also for diagnosis after a first seizure." @default.
• W4308258980 created "2022-11-09" @default.
• W4308258980 creator A5001532692 @default.
• W4308258980 creator A5005491067 @default.
• W4308258980 creator A5009946179 @default.
• W4308258980 creator A5015546124 @default.
• W4308258980 creator A5016639346 @default.
• W4308258980 creator A5027120219 @default.
• W4308258980 creator A5044876311 @default.
• W4308258980 creator A5054771038 @default.
• W4308258980 creator A5055075212 @default.
• W4308258980 creator A5079699201 @default.
• W4308258980 creator A5085008394 @default.
• W4308258980 creator A5086224910 @default.
• W4308258980 date "2022-11-05" @default.
• W4308258980 modified "2023-10-07" @default.
• W4308258980 title "Improved non-invasive detection of ictal and interictal epileptiform activity using Optically Pumped Magnetometers" @default.
• W4308258980 cites W1602389311 @default.
• W4308258980 cites W1605627163 @default.
• W4308258980 cites W1778721509 @default.
• W4308258980 cites W1964386293 @default.
• W4308258980 cites W1967125431 @default.
• W4308258980 cites W1974165416 @default.
• W4308258980 cites W1985160230 @default.
• W4308258980 cites W2004250919 @default.
• W4308258980 cites W2007133972 @default.
• W4308258980 cites W2010111760 @default.
• W4308258980 cites W2021845341 @default.
• W4308258980 cites W2034932565 @default.
• W4308258980 cites W2038735815 @default.
• W4308258980 cites W2050151003 @default.
• W4308258980 cites W2050347843 @default.
• W4308258980 cites W2060366056 @default.
• W4308258980 cites W2068765556 @default.
• W4308258980 cites W2073316336 @default.
• W4308258980 cites W2074136828 @default.
• W4308258980 cites W2084040282 @default.
• W4308258980 cites W2096221603 @default.
• W4308258980 cites W2101061776 @default.
• W4308258980 cites W2107974789 @default.
• W4308258980 cites W2130428257 @default.
• W4308258980 cites W2159338671 @default.
• W4308258980 cites W2311303842 @default.
• W4308258980 cites W2318186391 @default.
• W4308258980 cites W2353433850 @default.
• W4308258980 cites W2396004277 @default.
• W4308258980 cites W2402346616 @default.
• W4308258980 cites W2460859189 @default.
• W4308258980 cites W2512628654 @default.
• W4308258980 cites W2581653246 @default.
• W4308258980 cites W2606485316 @default.
• W4308258980 cites W2663530779 @default.
• W4308258980 cites W2737431233 @default.
• W4308258980 cites W2787926624 @default.
• W4308258980 cites W2791548393 @default.
• W4308258980 cites W2884766527 @default.
• W4308258980 cites W2884891549 @default.
• W4308258980 cites W2904035998 @default.
• W4308258980 cites W2913151934 @default.
• W4308258980 cites W2945333678 @default.
• W4308258980 cites W2948562641 @default.
• W4308258980 cites W2949327983 @default.
• W4308258980 cites W2952338767 @default.
• W4308258980 cites W2967267902 @default.
• W4308258980 cites W2969234156 @default.
• W4308258980 cites W2972910435 @default.
• W4308258980 cites W2978220154 @default.
• W4308258980 cites W2978679558 @default.
• W4308258980 cites W3002374698 @default.
• W4308258980 cites W3008532182 @default.
• W4308258980 cites W3013173332 @default.
• W4308258980 cites W3035564083 @default.
• W4308258980 cites W3047576883 @default.
• W4308258980 cites W3093268152 @default.
• W4308258980 cites W3102597665 @default.
• W4308258980 cites W3128261914 @default.
• W4308258980 cites W3136666376 @default.
• W4308258980 cites W3137373449 @default.
• W4308258980 cites W3145604009 @default.
• W4308258980 cites W3147650375 @default.
• W4308258980 cites W3155020404 @default.
• W4308258980 cites W3178778634 @default.
• W4308258980 cites W3186775379 @default.
• W4308258980 cites W3194657481 @default.
• W4308258980 cites W3197660546 @default.
• W4308258980 cites W3200893299 @default.
• W4308258980 cites W3201966318 @default.
• W4308258980 cites W3217134070 @default.
• W4308258980 cites W4200325664 @default.
• W4308258980 cites W4206021577 @default.
• W4308258980 cites W4213266885 @default.
• W4308258980 cites W4220819052 @default.
• W4308258980 cites W4224252765 @default.
• W4308258980 cites W4225299985 @default.
• W4308258980 cites W4225307071 @default.
• W4308258980 cites W4243708086 @default.
• W4308258980 cites W4281649554 @default.
• W4308258980 cites W4283700911 @default.
• W4308258980 cites W4283731272 @default.
• W4308258980 cites W4294808387 @default.

• next